Metformin attenuates alveolar bone destruction in mice with apical periodontitis and inhibits pro-inflammatory cytokine synthesis in lipopolysaccharide-stimulated RAW264.7 through the AMPK-mTOR-NF-κB pathway
二甲双胍可减轻小鼠根尖周炎的牙槽骨破坏,并通过 AMPK-mTOR-NF-κB 通路抑制脂多糖刺激的 RAW264.7 细胞中促炎细胞因子的合成。
期刊:Frontiers in Immunology
影响因子:5.7
doi:10.3389/fimmu.2025.1643676
Chunmei Ren,Kento Tazawa,Nobuyuki Kawashima,Risa Ohshima,Yamato Okada,Shihan Wang,Ziniu Yu,Peifeng Han,Yujin Ohsugi,Sayaka Katagiri,Takashi Okiji
细胞生物学
炎症/感染
信号转导
MTOR
NF-κB
mTOR
AMPK