日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Efficacies of artemether-lumefantrine, artesunate-amodiaquine, dihydroartemisinin-piperaquine, and artesunate-pyronaridine for the treatment of uncomplicated Plasmodium falciparum malaria in children aged 6 months to 10 years in Uganda: a randomised, open-label, phase 4 clinical trial

一项在乌干达开展的随机、开放标签的4期临床试验,旨在评估蒿甲醚-苯芴醇、青蒿琥酯-阿莫地喹、双氢青蒿素-哌喹和青蒿琥酯-吡咯萘啶联合用药治疗6个月至10岁儿童单纯性恶性疟疾的疗效。

Kamya, Moses R; Nankabirwa, Joaniter I; Ebong, Chris; Asua, Victor; Kiggundu, Moses; Orena, Stephen; Okitwi, Martin; Tukwasibwe, Stephen; Agaba, Bosco; Kyabayinze, Daniel; Opigo, Jimmy; Rutazana, Damian; Binagwa, Benjamin; Mugwanya, Edward; Babirye, Shakira; Sebikaari, Gloria; Condo, Patrick M; Appiah, Grace; Nsobya, Sam L; Conrad, Melissa D; Rosenthal, Philip J; Moriarty, Leah F; Yeka, Adoke

Changes in susceptibility of Plasmodium falciparum to antimalarial drugs in Uganda over time: 2019-2024

2019-2024年乌干达恶性疟原虫对疟疾药物敏感性的变化

Okitwi, Martin; Orena, Stephen; Tumwebaze, Patrick K; Katairo, Thomas; Taremwa, Yoweri; Byaruhanga, Oswald; Tukwasibwe, Stephen; Nsobya, Samuel L; Legac, Jennifer; Bailey, Jeffrey A; Cooper, Roland A; Conrad, Melissa D; Rosenthal, Philip J

Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance

在青蒿素部分耐药性的背景下,寻找下一代抗疟疾三氧杂环戊烷类药物。

Klope, Matthew T; Talukder, Poulami; Blank, Brian R; Chelebieva, Sevil; Chen, Jun; Fontaine, Shaun D; Gonciarz, Ryan L; Jaishankar, Priyadarshini; Lee, Grace J; Legac, Jennifer; Mathur, Vineet; Narayan, Avani; Okitwi, Martin; Orena, Stephen; Settineri, Nicholas S; Tapia, Juan A; Taremwa, Yoweri; Tumwebaze, Patrick K; Vinod, Aswathy; Burrows, Jeremy N; Rosenthal, Philip J; Cooper, Roland A; Renslo, Adam R

Gametocyte production and transmission fitness of African and Asian Plasmodium falciparum isolates with differential susceptibility to artemisinins

对青蒿素敏感性不同的非洲和亚洲恶性疟原虫分离株的配子体产生和传播适应性

Proellochs, Nicholas I; Andolina, Chiara; Ramjith, Jordache; Stoter, Rianne; van Gemert, Geert-Jan; Graumans, Wouter; Campino, Susana; Vanheer, Leen N; Okitwi, Martin; Tumwebaze, Patrick K; Conrad, Melissa D; Clark, Taane G; Fidock, David A; Ménard, Didier; Mok, Sachel; Bousema, Teun

A novel locus associated with decreased susceptibility of Plasmodium falciparum to lumefantrine and dihydroartemisinin has emerged and spread in Uganda

一种与恶性疟原虫对蒿甲醚和双氢青蒿素敏感性降低相关的新基因位点已在乌干达出现并传播。

Niare, Karamoko; Tafesse, Bersabeh; Treat, Mayland; Sadler, Jacob; Okitwi, Martin; Orena, Stephen; Asua, Victor; Kreutzfeld, Oriana; Legac, Jenny; Samuel, Nsobya L; Yeka, Adoke; Rosenthal, Phillip J; Juliano, Jonathan J; Bailey, Jeffrey A; Conrad, Melissa D

Potent Acridone Antimalarial against All Three Life Stages of Plasmodium

强效抗疟药吖啶酮,可对抗疟原虫所有三个生命阶段

Kancharla, Papireddy; Dodean, Rozalia A; Li, Yuexin; Zhang, Xiaowei; Kelly, Sean; Charlton, Jordan; Binauhan, Angley; Garcia, Laurize; Caridha, Diana; Madejczyk, Michael S; Jin, Xiannu; Dennis, William E; Kudyba, Karl; McEnearney, Sharon; Lee, Partricia J; Blount, Cameron; DeLuca, Jesse; Vuong, Chua; Pannone, Kristina; Dinh, Hieu T; Mdaki, Kennedy; Leed, Susan; Martin, Monica L; Pybus, Brandon S; Chimong, Anongruk; Cui, Liwang; Vega-Rodriguez, Joel; Okitwi, Martin; Kreutzfeld, Oriana; Docan, Christina; Green, Carol; Liu, Ying; Agulay, Aaron; Mirsalis, Jon; Farrell, Sarah N; McFadden, Geoffrey I; Goodman, Christopher D; Probst, Alexandra S; Nilsen, Aaron; Catteruccia, Flaminia; Rosenthal, Philip J; Riscoe, Michael; Cooper, Roland; Roth, Alison; Kelly, Jane

Natural killer cell antibody-dependent cellular cytotoxicity to Plasmodium falciparum is impacted by cellular phenotypes, erythrocyte polymorphisms, parasite diversity and intensity of transmission

自然杀伤细胞抗体依赖性细胞对恶性疟原虫的细胞毒性受细胞表型、红细胞多态性、寄生虫多样性和传播强度的影响

Stephen Tukwasibwe, Savannah Nicole Lewis, Yoweri Taremwa, Kattria van der Ploeg, Kathleen D Press, Maureen Ty, Felistas Namirimu Nankya, Kenneth Musinguzi, Evelyn Nansubuga, Florian Bach, Martin Chamai, Martin Okitwi, Gerald Tumusiime, Annettee Nakimuli, Francesco Colucci, Moses R Kamya, Joaniter I

Ex vivo susceptibilities to ganaplacide and diversity in potential resistance mediators in Ugandan Plasmodium falciparum isolates

乌干达恶性疟原虫分离株对加那普拉西德的体外敏感性及潜在耐药介质的多样性

Kreutzfeld, Oriana; Orena, Stephen; Okitwi, Martin; Tumwebaze, Patrick K; Byaruhanga, Oswald; Katairo, Thomas; Conrad, Melissa D; Legac, Jennifer; Garg, Shreeya; Crudale, Rebecca; Aydemir, Ozkan; Giesbrecht, David; Nsobya, Samuel L; Blasco, Benjamin; Duffey, Maelle; Rouillier, Melanie; Bailey, Jeffrey A; Cooper, Roland A; Rosenthal, Philip J

The extended recovery ring-stage survival assay is a scalable alternative for artemisinin susceptibility phenotyping of fresh Plasmodium falciparum isolates

扩展恢复环状期存活率测定法是一种可扩展的替代方法,可用于对新鲜分离的恶性疟原虫进行青蒿素敏感性表型分析。

Okitwi, Martin; Shoue, Douglas A; Checkley, Lisa A; Orena, Stephen; Ceja, Frida G; Taremwa, Yoweri; Tumwebaze, Patrick K; Katairo, Thomas; Byaruhanga, Oswald; Sievert, Mackenzie A C; Garg, Shreeya; Kreutzfeld, Oriana K; Legac, Jennifer; Bailey, Jeffrey A; Nsobya, Sam L; Conrad, Melissa D; Rosenthal, Philip J; Ferdig, Michael T; Cooper, Roland A

Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline

乌干达恶性疟原虫分离株对抗疟药物研发管线的敏感性

Kreutzfeld, Oriana; Tumwebaze, Patrick K; Okitwi, Martin; Orena, Stephen; Byaruhanga, Oswald; Katairo, Thomas; Conrad, Melissa D; Rasmussen, Stephanie A; Legac, Jennifer; Aydemir, Ozkan; Giesbrecht, David; Forte, Barbara; Campbell, Peter; Smith, Alasdair; Kano, Hiroki; Nsobya, Samuel L; Blasco, Benjamin; Duffey, Maelle; Bailey, Jeffrey A; Cooper, Roland A; Rosenthal, Philip J