日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy

微调 BACH2 剂量可平衡干细胞特性和效应功能,从而增强抗肿瘤 T 细胞疗法。

Conti, Alberto G; Evans, Alexander C; von Linde, Teresa; Deguit, Christian Deo T; Whiteside, Sarah K; Wesolowski, Alexander J; Imianowski, Charlotte J; Yamashita-Kanemaru, Yumi; Dahmani, Layla; Chapman, Jack; Pillay, Ardon M; Al-Deka, Aws; Greaves, Randy; Burton, Oliver; Vardaka, Panagiota; Sampurno, Shienny; Pérez-Núñez, Iván; Saw, Nicole Y L; Yang, Jie; Howden, Andrew J M; Okkenhaug, Klaus; Mitra, Suman; Swiatczak, Bartlomiej; Parish, Ian A; Roychoudhuri, Rahul

Phosphoinositide 3-kinase δ activity in patients with systemic lupus erythematosus

系统性红斑狼疮患者的磷脂酰肌醇3-激酶δ活性

Mirfazeli, Elham Sadat; Kharkar, Shalmalee; Tsang-A-Sjoe, Michel W P; Papapietro, Olivier; Niewczas, Izabella; Parra Sanchez, Agner R; Chandra, Anita; Okkenhaug, Klaus; Bultink, Irene E M; Mebius, Reina E; Clark, Jonathan; Voskuyl, Alexandre E; Nejentsev, Sergey

Perturbing local steroidogenesis to improve breast cancer immunity.

干扰局部类固醇生成以提高乳腺癌免疫力

Zhao Qiuchen, Pramanik Jhuma, Lu Yongjin, Homer Natalie Z M, Imianowski Charlotte J, Zhang Baojie, Iqbal Muhammad, Shaji Sanu Korumadathil, Morris Andrew Conway, Roychoudhuri Rahul, Okkenhaug Klaus, Qiu Pengfei, Mahata Bidesh

Intratumoral antigen signaling traps CD8(+) T cells to confine exhaustion to the tumor site

肿瘤内抗原信号传导会捕获 CD8(+) T 细胞,从而将 T 细胞耗竭限制在肿瘤部位。

Takahashi, Munetomo; So, Tsz Y; Chamberlain-Evans, Vitalina; Hughes, Robert; Yam-Puc, Juan Carlos; Kania, Katarzyna; Ruhle, Michelle; Mann, Tiffeney; Schuijs, Martijn J; Coupland, Paul; Naisbitt, Dean; Halim, Timotheus Y F; Lyons, Paul A; Lio, Pietro; Roychoudhuri, Rahul; Okkenhaug, Klaus; Adams, David J; Smith, Ken G C; Jodrell, Duncan I; Chapman, Michael A; Thaventhiran, James E D

PI3K Inhibitors in Hematology: When One Door Closes…

PI3K抑制剂在血液学中的应用:当一扇门关闭时……

Skånland, Sigrid S; Okkenhaug, Klaus; Davids, Matthew S

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development.

调节性 T 细胞中缺乏磷脂酰肌醇 3-激酶 VPS34 会导致致命的淋巴增生性疾病,但并不影响其发育

Courreges Christina J F, Davenport Elizabeth C M, Bilanges Benoit, Rebollo-Gomez Elena, Hukelmann Jens, Schoenfelder Priya, Edgar James R, Sansom David, Scudamore Cheryl L, Roychoudhuri Rahul, Garden Oliver A, Vanhaesebroeck Bart, Okkenhaug Klaus

Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T(reg) depletion

传统T细胞获得抑制功能后,T(reg)细胞耗竭会限制抗肿瘤免疫力。

Whiteside, Sarah K; Grant, Francis M; Alvisi, Giorgia; Clarke, James; Tang, Leqi; Imianowski, Charlotte J; Zhang, Baojie; Evans, Alexander C; Wesolowski, Alexander J; Conti, Alberto G; Yang, Jie; Lauder, Sarah N; Clement, Mathew; Humphreys, Ian R; Dooley, James; Burton, Oliver; Liston, Adrian; Alloisio, Marco; Voulaz, Emanuele; Langhorne, Jean; Okkenhaug, Klaus; Lugli, Enrico; Roychoudhuri, Rahul

Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion

注意间隙:RASA2 和 RASA3 GTP酶激活蛋白作为T细胞活化和黏附的守门人

Johansen, Kristoffer H; Golec, Dominic P; Okkenhaug, Klaus; Schwartzberg, Pamela L

BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis

BACH2限制NK细胞的成熟和功能,从而限制机体对癌症转移的免疫力。

Imianowski, Charlotte J; Whiteside, Sarah K; Lozano, Teresa; Evans, Alexander C; Benson, Jayme D; Courreges, Christina J F; Sadiyah, Firas; Lau, Colleen M; Zandhuis, Nordin D; Grant, Francis M; Schuijs, Martijn J; Vardaka, Panagiota; Kuo, Paula; Soilleux, Elizabeth J; Yang, Jie; Sun, Joseph C; Kurosaki, Tomohiro; Okkenhaug, Klaus; Halim, Timotheus Y F; Roychoudhuri, Rahul

Correction for Bjørgo et al., "Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/β-Arrestin/cAMP Phosphodiesterase 4 Complex"

对 Bjørgo 等人的论文“磷脂酰肌醇 3-激酶和环磷酸腺苷 (cAMP)-蛋白激酶 A 信号通路在蛋白激酶 B/β-阻遏蛋白/cAMP 磷酸二酯酶 4 复合物水平上的交叉对话”的更正

Bjørgo, Elisa; Solheim, Silje A; Abrahamsen, Hilde; Baillie, George S; Brown, Kim M; Berge, Torunn; Okkenhaug, Klaus; Houslay, Miles D; Taskén, Kjetil