日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity

一种具有抗疟活性的II型人激酶抑制剂可抑制恶性疟原虫蛋白激酶6和血红素的形成。

Flore Nardella ,Tiantian Jiang ,Lushun Wang ,Monica J Bohmer ,Subhoja Chakraborty ,John Okombo ,Jaeson Calla ,Tatiane Macedo Silva ,Samuel Pazicky ,Jianwei Che ,Jin Jeon ,Evie Vincent ,Nonlawat Boonyalai ,Rachael Coyle ,Mairi J Buchanan ,Samuel Schaefer ,Daisy Chen ,Amaan Khan ,Emily Mayville ,Mariana Laureano De Souza ,Mayland Treat ,Jordan Charlton ,Patrick K Tumwebaze ,Seth Tjia ,Lukas Montejo ,Karen Cover ,Philip J Rosenthal ,Roland A Cooper ,Zbynek Bozdech ,Marcus C S Lee ,Ratna Chakrabarti ,Sanjay A Desai ,David A Fidock ,Jinhua Wang ,Nathanael S Gray ,Elizabeth A Winzeler ,Debopam Chakrabarti

Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity.

喹喔啉类抗血吸虫化合物具有很强的抗疟原虫活性

Rawat Mukul, Padalino Gilda, Adika Edem, Okombo John, Yeo Tomas, Brancale Andrea, Fidock David A, Hoffmann Karl F, Lee Marcus C S

Pathways between intimate partner violence and HIV care and treatment during pregnancy and postpartum: A qualitative study in southwestern Kenya

亲密伴侣暴力与孕产期艾滋病毒护理和治疗之间的关联路径:肯尼亚西南部的一项定性研究

Schrubbe, Leah; Makokha, Catherine; Kimbo, Liza; Helova, Anna; Kwena, Zachary; Darbes, Lynae; Okombo, Moses; Owengah, Evelyne; Calvert, Clara; Stöckl, Heidi; Bukusi, Elizabeth A; Turan, Janet M; Hatcher, Abigail M

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

恶性疟原虫体外系统进化揭示了耐药性的关键决定因素

Luth Madeline R, Godinez-Macias Karla P, Chen Daisy, Okombo John, Thathy Vandana, Cheng Xiu, Daggupati Sindhu, Davies Heledd, Dhingra Satish K, Economy Jan M, Edgar Rebecca C S, Gomez-Lorenzo Maria G, Istvan Eva S, Jado Juan Carlos, LaMonte Gregory M, Melillo Bruno, Mok Sachel, Narwal Sunil K, Ndiaye Tolla, Ottilie Sabine, Palomo Diaz Sara, Park Heekuk, Peña Stella, Rocamora Frances, Sakata-Kato Tomoyo, Small-Saunders Jennifer L, Summers Robert L, Tumwebaze Patrick K, Vanaerschot Manu, Xia Guoqin, Yeo Tomas, You Ashley, Gamo Francisco-Javier, Goldberg Daniel E, Lee Marcus C S, McNamara Case W, Ndiaye Daouda, Rosenthal Philip J, Schreiber Stuart L, Serra Gloria, De Siqueira-Neto Jair Lage, Skinner-Adams Tina S, Uhlemann Anne-Catrin, Kato Nobutaka, Lukens Amanda K, Wirth Dyann F, Fidock David A, Winzeler Elizabeth A

Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission.

疟原虫环核苷酸磷酸二酯酶抑制剂可阻断无性血液期发育和蚊子传播

Gomez-Gonzalez Paula-Josefina, Gupta Antima, Drought Laura G, Patel Avnish, Okombo John, van der Watt Mariëtte, Walker-Gray Ryan, Schindler Kyra A, Burkhard Anna Y, Yeo Tomas, Narwal Sunil K, Bloxham Talia S, Flueck Christian, Walker Eloise M, Rey Joshua A, Fairhurst Kate J, Reader Janette, Park Heekuk, Pollard Harry G, Stewart Lindsay B, Brandner-Garrod Luke, Kristan Mojca, Sterk Geert-Jan, van Nuland Youri M, Manko Emilia, van Schalkwyk Donelly A, Zheng Yang, Leurs Rob, Dechering Koen J, Aguiar Anna Caroline C, Guido Rafael V C, Pereira Dhelio B, Tumwebaze Patrick K, Nosbya Samuel L, Rosenthal Philip J, Cooper Roland A, Palmer Mike, Parkinson Tanya, Burrows Jeremy N, Uhlemann Anne-Catrin, Birkholtz Lyn-Marié, Small-Saunders Jennifer L, Duffy James, Fidock David A, Brown Alan, Gardner Mark, Baker David A

Identification of the drug/metabolite transporter 1 as a marker of quinine resistance in a NF54×Cam3.II P. falciparum genetic cross

鉴定出药物/代谢物转运蛋白 1 作为 NF54×Cam3.II 恶性疟原虫基因杂交中奎宁抗性的标志

Mariko Kanai, Sachel Mok, Tomas Yeo, Melanie J Shears, Leila S Ross, Jin H Jeon, Sunil Narwal, Meseret T Haile, Abhai K Tripathi, Godfree Mlambo, Jonathan Kim, Eva Gil-Iturbe, John Okombo, Kate J Fairhurst, Talia Bloxham, Jessica L Bridgford, Tanaya Sheth, Kurt E Ward, Heekuk Park, Felix D Rozenberg

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

产生突变寄生虫以推动恶性疟原虫抗药性的发现

Krittikorn Kümpornsin, Theerarat Kochakarn, Tomas Yeo, John Okombo, Madeline R Luth, Johanna Hoshizaki, Mukul Rawat, Richard D Pearson, Kyra A Schindler, Sachel Mok, Heekuk Park, Anne-Catrin Uhlemann, Gouranga P Jana, Bikash C Maity, Benoît Laleu, Elodie Chenu, James Duffy, Sonia Moliner Cubel, Virg

The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance

恶性疟原虫 ABC 转运蛋白 ABCI3 赋予寄生虫株依赖性多效抗疟药物耐药性

James M Murithi, Ioanna Deni, Charisse Flerida A Pasaje, John Okombo, Jessica L Bridgford, Nina F Gnädig, Rachel L Edwards, Tomas Yeo, Sachel Mok, Anna Y Burkhard, Olivia Coburn-Flynn, Eva S Istvan, Tomoyo Sakata-Kato, Maria G Gomez-Lorenzo, Annie N Cowell, Kathryn J Wicht, Claire Le Manach, Gavreel

3-Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum

3-羟基丙脒,一类针对恶性疟原虫的新型口服抗疟药

Tanja C Knaab, Jana Held, Bjoern B Burckhardt, Kelly Rubiano, John Okombo, Tomas Yeo, Sachel Mok, Anne-Catrin Uhlemann, Beate Lungerich, Christoph Fischli, Lais Pessanha de Carvalho, Benjamin Mordmüller, Sergio Wittlin, David A Fidock, Thomas Kurz

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

基因筛选揭示了血红素代谢在青蒿素敏感性中的核心作用

Clare R Harding #,Saima M Sidik #,Boryana Petrova #,Nina F Gnädig,John Okombo,Alice L Herneisen,Kurt E Ward,Benedikt M Markus,Elizabeth A Boydston,David A Fidock,Sebastian Lourido