日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

NRF2 controls a diverse network of antiviral effectors with p62 acting as a central restriction factor effective across virus families

NRF2 控制着一个多样化的抗病毒效应因子网络,其中 p62 作为一种核心限制因子,对多种病毒家族均有效。

Pedersen, Alice; Blay-Cadanet, Julia; Storgaard, Jacob; Hernaez, Bruno; Thyrsted, Jacob; Bach-Nielsen, Cecilie S; Twayana, Krishna; Jørgensen, Sofie E; Rio-Bergé, Clàudia; Poulsen, Cecilie; Thielke, Anne L; Thomsen, Emil A; Kalucka, Joanna; Olagnier, David; Luo, Yonglun; Reggiori, Fulvio; Mogensen, Trine H; Alcamí, Antonio; Hansen, Anne Louise; Holm, Christian K

NRF2 activators and the inhibitor of nuclear export, selinexor, restrict coronaviruses by targeting a network involving ACE2, TMPRSS2, and XPO1 through an NRF2-independent mechanism.

NRF2 激活剂和核输出抑制剂 selinexor 通过一种不依赖于 NRF2 的机制,靶向涉及 ACE2、TMPRSS2 和 XPO1 的网络,从而限制冠状病毒。

Waqas Fakhar H, Silva da Costa Leandro, Zapatero-Belinchón Francisco J, Carter-Timofte Madalina E, Lasswitz Lisa, van der Horst Demi, Möller Rebecca, Dahlmann Julia, Olmer Ruth, Geffers Robert, Gerold Gisa, Olagnier David, Pessler Frank

Fragment-Based Drug Discovery of Novel High-affinity, Selective, and Anti-inflammatory Inhibitors of the Keap1-Nrf2 Protein-Protein Interaction

基于片段的新型高亲和力、选择性抗炎抑制剂在Keap1-Nrf2蛋白-蛋白相互作用中的应用

Lin, Chunyu; Narayanan, Dilip; Barreca, Marilia; Poulsen, Cecilie; da Costa, Leandro Silva; Chen, Xiangrong; Wichman, Kendall G; Charley, Cherisse A; Lindsay, Jaslin L; Dezfouli, Mahya; Vlissari, Dimitra; Mortensen, Thomas S; Chan, Camilla B; Wang, Jingyi; Richardson, William; Manning, Charlotte E; Chen, Zhuoyao; Zang, Jie; Käck, Helena; Gajhede, Michael; Bullock, Alex N; Blake, David J; Olagnier, David; Bach, Anders

Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment.

人血浆的蛋白水解分析揭示了一种具有免疫活性的补体 C3 片段。

Demir Fatih, Kovalenko Elina, Lassé Moritz, Svenningsen Esben B, Bernth Jensen Jens M, Billing Anja M, Groeneveld Kathrin, Hutzfeldt Arvid, Nilges Lars, Guerra João P L, Pietrzak-Lichwa Krzysztof J, Tan Yifan, Colby Elizabeth, Hansen Annette G, Kurmasheva Naziia, Olagnier David, Choi Dongwoo, Richter Mika M, Laufer Sandra D, Braun Fabian, Johnson Sally A, Krüger Marcus, Huber Tobias B, Hoxha Elion, Steinmetz Oliver M, Mrowka Ralf, Melderis Simon, Saleem Moin A, Poulsen Thomas B, Andersen Gregers R, Thiel Steffen, Troldborg Anne, Rinschen Markus M

Sustained inflammation during human T-lymphotropic virus type 1 infection: a wildfire contributing to disease progression

人类T淋巴细胞病毒1型感染期间的持续性炎症:加速疾病进展的“野火”。

Shegefti, Saina; Alaei, Mahsa; Ghahari, Nazanin; Telittchenko, Roman; Hanafi, Shahin Bolori; Isnard, Stephane; Routy, Jean-Pierre; Olagnier, David; van Grevenynghe, Julien

The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation

HIF转录网络在神经元中发挥固有的抗病毒活性,并限制脑部炎症。

Ensieh Farahani,Line S Reinert,Ryo Narita,Manutea C Serrero,Morten Kelder Skouboe,Demi van der Horst,Sonia Assil,Baocun Zhang,Marie B Iversen,Eugenio Gutierrez,Hossein Hazrati,Mogens Johannsen,David Olagnier,Reiner Kunze,Mark Denham,Trine H Mogensen,Michael Lappe,Søren R Paludan

HSP60 controls mitochondrial ATP generation for optimal virus-specific IL-21-producing CD4 and cytotoxic CD8 memory T cell responses

HSP60 控制线粒体 ATP 生成,以实现最佳的病毒特异性 IL-21 产生 CD4 和细胞毒性 CD8 记忆 T 细胞反应

Nazanin Ghahari, Saina Shegefti, Mahsa Alaei, Amine Amara, Roman Telittchenko, Stéphane Isnard, Jean-Pierre Routy, David Olagnier, Julien van Grevenynghe

Editorial: Host-cell pathways modulated by influenza virus infection: new insight into pathogenetic mechanisms and cell-targeted antiviral strategies

社论:流感病毒感染调控宿主细胞通路:致病机制和靶向细胞抗病毒策略的新见解

De Angelis, Marta; Checconi, Paola; Olagnier, David

Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1

转基因 mRNA 翻译的适应性增强了溶瘤 HSV1 的抗癌功效

Huy-Dung Hoang, Aida Said, Nasana Vaidya, Victoria H Gilchrist, Kyle Malone, Usha Kabilan, Serena Topshee, Xiao Xiang, An-Dao Yang, David Olagnier, Karen Mossman, Shawn T Beug, Seyed Mehdi Jafarnejad, Samuel T Workenhe, Tyson E Graber, Tommy Alain

NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner

NRF2激活剂通过干扰病毒核糖核蛋白(RNP)的核质输出,以不依赖于NRF2的方式抑制甲型流感病毒的复制。

Fakhar H Waqas,Mahmoud Shehata,Walid A M Elgaher,Antoine Lacour,Naziia Kurmasheva,Fabio Begnini,Anders E Kiib,Julia Dahlmann  ,Chutao Chen,Andreas Pavlou,Thomas B Poulsen,Sylvia Merkert  ,Ulrich Martin  ,Ruth Olmer  ,David Olagnier,Anna K H Hirsch  ,Stephan Pleschka  ,Frank Pessler