日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Executive summary: It's wrong not to test: The case for universal, frequent rapid COVID-19 testing

概要:不进行检测是错误的:普及、频繁进行新冠病毒快速检测的必要性

Johnson-León, Maureen; Caplan, Arthur L; Kenny, Louise; Buchan, Iain; Fesi, Leah; Olhava, Phoebe; Nsobila Alugnoa, Desmond; Aspinall, Mara G; Costanza, Emily; Desharnais, Brianna; Price, Corinne; Frankle, Jon; Binding, Jonas; Working Group, Rapid Tests; Ramirez, Cherie Lynn

Mechanisms of Pinometostat (EPZ-5676) Treatment-Emergent Resistance in MLL-Rearranged Leukemia

Pinometostat (EPZ-5676) 治疗导致 MLL 重排白血病出现耐药性的机制

Carly T Campbell, Jessica N Haladyna, David A Drubin, Ty M Thomson, Michael J Maria, Taylor Yamauchi, Nigel J Waters, Edward J Olhava, Roy M Pollock, Jesse J Smith, Robert A Copeland, Stephen J Blakemore, Kathrin M Bernt, Scott R Daigle

MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition

MLL部分串联重复白血病细胞对小分子DOT1L抑制剂敏感

Kühn, Michael W M; Hadler, Michael J; Daigle, Scott R; Koche, Richard P; Krivtsov, Andrei V; Olhava, Edward J; Caligiuri, Michael A; Huang, Gang; Bradner, James E; Pollock, Roy M; Armstrong, Scott A

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

强效抑制DOT1L可治疗MLL融合白血病

Daigle, Scott R; Olhava, Edward J; Therkelsen, Carly A; Basavapathruni, Aravind; Jin, Lei; Boriack-Sjodin, P Ann; Allain, Christina J; Klaus, Christine R; Raimondi, Alejandra; Scott, Margaret Porter; Waters, Nigel J; Chesworth, Richard; Moyer, Mikel P; Copeland, Robert A; Richon, Victoria M; Pollock, Roy M

Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l

MLL-AF6融合癌基因引起的白血病转化需要H3K79甲基转移酶Dot1l。

Deshpande, Aniruddha J; Chen, Liying; Fazio, Maurizio; Sinha, Amit U; Bernt, Kathrin M; Banka, Deepti; Dias, Stuart; Chang, Jenny; Olhava, Edward J; Daigle, Scott R; Richon, Victoria M; Pollock, Roy M; Armstrong, Scott A

Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l

通过基因失活或药理抑制 H3K79 甲基转移酶 Dot1l 来消除 MLL-AF10 和 CALM-AF10 介导的转化

L Chen, A J Deshpande, D Banka, K M Bernt, S Dias, C Buske, E J Olhava, S R Daigle, V M Richon, R M Pollock, S A Armstrong

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor

强效小分子 DOT1L 抑制剂选择性杀死混合谱系白血病细胞

Scott R Daigle, Edward J Olhava, Carly A Therkelsen, Christina R Majer, Christopher J Sneeringer, Jeffrey Song, L Danielle Johnston, Margaret Porter Scott, Jesse J Smith, Yonghong Xiao, Lei Jin, Kevin W Kuntz, Richard Chesworth, Mikel P Moyer, Kathrin M Bernt, Jen-Chieh Tseng, Andrew L Kung, Scott A

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit

对一系列新型非共价蛋白酶体抑制剂进行表征,这些抑制剂对 20S β5 亚基具有极高的效力和选择性。

Blackburn, Christopher; Gigstad, Kenneth M; Hales, Paul; Garcia, Khristofer; Jones, Matthew; Bruzzese, Frank J; Barrett, Cynthia; Liu, Jane X; Soucy, Teresa A; Sappal, Darshan S; Bump, Nancy; Olhava, Edward J; Fleming, Paul; Dick, Lawrence R; Tsu, Christopher; Sintchak, Michael D; Blank, Jonathan L

Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5

内源性斯巴汀(SPG20)被募集到内体和脂滴中,并与泛素E3连接酶AIP4和AIP5相互作用。

Bastea, Ligia I; Döppler, Heike; Pearce, Sarah E; Durand, Nisha; Spratley, Samantha J; Storz, Peter; Nordin, N; Guskov, A; Phua, T; Sahaf, N; Xia, Y; Lu, S; Eshaghi, H; Eshaghi, S; O'Leary, B; Rao, S K; Plaxton, W C; Blackburn, C; Gigstad, K M; Hales, P; Garcia, K; Jones, M; Bruzzese, F J; Barrett, C; Liu, J X; Soucy, T A; Sappal, D S; Bump, N; Olhava, E J; Fleming, P; Dick, L R; Tsu, C; Sintchak, M D; Blank, J L; Nomikos, M; Elgmati, K; Theodoridou, M; Calver, B L; Cumbes, B; Nounesis, G; Swann, K; Lai, F A; Brand, M D; Nicholls, D G; Edwards, T L; Clowes, V E; Tsang, H T H; Connell, J W; Sanderson, C M; Luzio, J P; Reid, E