RRM2B deficiency causes dATP and dGTP depletion through enhanced degradation and slower synthesis.
RRM2B 缺乏会导致 dATP 和 dGTP 的消耗,这是由于降解增强和合成减慢所致
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2503531122
Awoyomi Ololade Folajimi, Gorospe Choco Michael, Das Biswajit, Mishra Pradeep, Sharma Sushma, Diachenko Olena, Nilsson Anna Karin, Tran Phong, Wanrooij Paulina H, Chabes Andrei