日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and development of a new oxazolidinone with reduced toxicity for the treatment of tuberculosis

发现和开发一种毒性降低的新型噁唑烷酮类药物用于治疗结核病

Crowley, Brendan M; Boshoff, Helena I; Boving, Aidan; Tan, Vee Y; Zhu, Jianghai; Hoyt, Forrest; Miller, Randy R; Ehrhart, Julie; Boyce, Christopher W; Young, Katherine; Nantermet, Philippe G; Su, Jing; Yang, Lihu; Painter, Ronald E; Corcoran, Emily B; Hoar, Jason L; Oh, Sangmi; Holtzman, David L; Levi, Micha; Anderson, Aparna; Otieno, Monicah A; Zimmerman, Matthew; Kaya, Firat; Massoudi, Lisa M; Ramey, Michelle E; Bauman, Allison A; Lenaerts, Anne J; Roberston, Gregory T; Dartois, Véronique; Wells, Charles D; Barry, Clifton E 3rd; Olsen, David B

MK-7602: a potent multi-stage dual-targeting antimalarial

MK-7602:一种强效的多阶段双靶点抗疟药

Favuzza, Paola; Palandri, Josephine; de Lera Ruiz, Manuel; Bailey, Wendy; Boyce, Christopher W; Danziger, Andrew; Fawaz, Maria V; Kelly, Michael; Murgolo, Nicholas; Robbins, Jonathan A; Vavrek, Marissa; Zhao, Lianyun; Lei, Zhiyu; Guo, Zhuyan; Reaksudsan, Kitsanapong; Steel, Ryan W J; Hodder, Anthony N; Ngo, Anna; Dziekan, Jerzy M; Thompson, Jennifer K; Triglia, Tony; Birkinshaw, Richard W; Penington, Jocelyn Sietsma; Scally, Stephen W; Dans, Madeline G; Coyle, Rachael; Sevilleno, Nicole; Orban, Agnes; Feufack-Donfack, Lionel Brice; Popovici, Jean; Lee, Marcus C S; Papenfuss, Anthony; Lowes, Kym N; Sleebs, Brad E; McCarthy, James S; McCauley, John A; Boddey, Justin A; Olsen, David B; Cowman, Alan F

First-in-human safety and pharmacokinetics of MK-7602, the antimalarial inhibitor of plasmepsins IX/X, in single- and multiple-ascending-dose studies

MK-7602(一种抗疟疾药物,可抑制疟原虫蛋白酶IX/X)的首次人体安全性和药代动力学研究(单次和多次递增剂量研究)

Stanley, Susan E; Carstens, Russ P; Liberti, Maria V; Eertmans, Ward; Vranckx, Myrthel; Longo, Diane; Ghosal, Nairita; Vavrek, Marissa; Olsen, David B; Cowman, Alan F; Reynders, Tom; Cilissen, Caroline; Laethem, Tine; Rottey, Sylvie; Robbins, Jonathan A; Stoch, S Aubrey; Nussbaum, Jesse

Efficacy evaluation of the S-adenosylhomocysteine hydrolase inhibitor MSD-914 in rhesus macaques (Macaca Mulatta) challenged with Ebola virus by the intramuscular route

对经肌肉注射途径感染埃博拉病毒的恒河猴(Macaca mulatta)进行S-腺苷高半胱氨酸水解酶抑制剂MSD-914的疗效评价

Johnston, Sara C; Ginnetti, Anthony T; Twenhafel, Nancy A; Norris, Sarah L W; Chen, Shiying; Moore, Josh L; Boyce, Christopher W; Frick, Ondraya M; Dyer, Dave N; Marsh, Donald J; Stevens, Stephen C; Knapp, Walter F; Berrier, Kerry L; Wan, Hui; Adam, Gregory C; Hartingh, Timothy J; Esham, Heather L; Fiallos, Jimmy O; Blue, Eugene L; Sifford, Willie B; Latty, Jonathan D; Mills, Harold L; Alli, Nazira A; Piper, Ashley E; Goodson, Aimee I; Meinig, J Matthew; Olsen, David B; Lieberman, Linda A; Panchal, Rekha G

Structure-activity analysis of imino-pyrimidinone-fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors

亚氨基嘧啶酮稠合吡咯烷的结构活性分析有助于开发双重血浆素V和血浆素X抑制剂。

Hodder, Anthony N; Sleebs, Brad E; Adams, Greg; Rezazadeh, Sina; Ngo, Anna; Jarman, Kate; Scally, Stephen; Czabotar, Peter; Wang, Hongwu; McCauley, John A; Olsen, David B; Cowman, Alan F

Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus

三环吡咯并嘧啶B型DNA促旋酶抑制剂对脓肿分枝杆菌的活性

Madani, Abdeldjalil; Negatu, Dereje A; El Marrouni, Abdellatif; Miller, Randy R; Boyce, Christopher W; Murgolo, Nicholas; Bungard, Christopher J; Zimmerman, Matthew D; Dartois, Véronique; Gengenbacher, Martin; Olsen, David B; Dick, Thomas

Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions

由制药公司和学术机构组成的联盟对抗结核分枝杆菌的β-内酰胺类抗生素进行鉴定

Gold, Ben; Zhang, Jun; Quezada, Landys Lopez; Roberts, Julia; Ling, Yan; Wood, Madeleine; Shinwari, Wasima; Goullieux, Laurent; Roubert, Christine; Fraisse, Laurent; Bacqué, Eric; Lagrange, Sophie; Filoche-Rommé, Bruno; Vieth, Michal; Hipskind, Philip A; Jungheim, Louis N; Aubé, Jeffrey; Scarry, Sarah M; McDonald, Stacey L; Li, Kelin; Perkowski, Andrew; Nguyen, Quyen; Dartois, Véronique; Zimmerman, Matthew; Olsen, David B; Young, Katherine; Bonnett, Shilah; Joerss, Douglas; Parish, Tanya; Boshoff, Helena I; Arora, Kriti; Barry, Clifton E 3rd; Guijarro, Laura; Anca, Sara; Rullas, Joaquín; Rodríguez-Salguero, Beatriz; Martínez-Martínez, Maria S; Porras-De Francisco, Esther; Cacho, Monica; Barros-Aguirre, David; Smith, Paul; Berthel, Steven J; Nathan, Carl; Bates, Robert H

DNA-Dependent Binding of Nargenicin to DnaE1 Inhibits Replication in Mycobacterium tuberculosis

纳曲霉素与DnaE1的DNA依赖性结合抑制结核分枝杆菌的复制

Chengalroyen, Melissa D; Mason, Mandy K; Borsellini, Alessandro; Tassoni, Raffaella; Abrahams, Garth L; Lynch, Sasha; Ahn, Yong-Mo; Ambler, Jon; Young, Katherine; Crowley, Brendan M; Olsen, David B; Warner, Digby F; Barry Iii, Clifton E; Boshoff, Helena I M; Lamers, Meindert H; Mizrahi, Valerie

The Tuberculosis Drug Accelerator at year 10: what have we learned?

结核病药物加速计划实施10周年:我们学到了什么?

Aldridge, Bree B; Barros-Aguirre, David; Barry, Clifton E 3rd; Bates, Robert H; Berthel, Steven J; Boshoff, Helena I; Chibale, Kelly; Chu, Xin-Jie; Cooper, Christopher B; Dartois, Véronique; Duncan, Ken; Fotouhi, Nader; Gusovsky, Fabian; Hipskind, Philip A; Kempf, Dale J; Lelièvre, Joël; Lenaerts, Anne J; McNamara, Case W; Mizrahi, Valerie; Nathan, Carl; Olsen, David B; Parish, Tanya; Petrassi, H Michael; Pym, Alexander; Rhee, Kyu Y; Robertson, Gregory T; Rock, Jeremy Michael; Rubin, Eric J; Russell, Betsy; Russell, David G; Sacchettini, James C; Schnappinger, Dirk; Schrimpf, Michael; Upton, Anna M; Warner, Peter; Wyatt, Paul Graham; Yuan, Ying

Generation of SARS-CoV-2 reporter replicon for high-throughput antiviral screening and testing

构建用于高通量抗病毒筛选和检测的SARS-CoV-2报告基因复制子

He, Xi; Quan, Shuo; Xu, Min; Rodriguez, Silveria; Goh, Shih Lin; Wei, Jiajie; Fridman, Arthur; Koeplinger, Kenneth A; Carroll, Steve S; Grobler, Jay A; Espeseth, Amy S; Olsen, David B; Hazuda, Daria J; Wang, Dai