日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

HMB-002: a monovalent antibody that elevates circulating VWF and FVIII levels for treatment of von Willebrand disease

HMB-002：一种单价抗体，可提高循环中VWF和FVIII水平，用于治疗血管性血友病。

期刊:Blood Advances
影响因子:7.1
doi:10.1182/bloodadvances.2025018516
Häger, Mattias; Zivkovic, Minka; Gandhi, Prafull S; Rasmussen, Caroline; Bonvoisin, Cécile; Harrison, Rane A; Poulsen, Emil; Huskens, Dana; Roest, Mark; Ferrara, Fortunato; Naretto, Anais; Renaud, Lionel; Olsen, Ole H; Eskesen, Nicolas O; Holten-Andersen, Lars; Malladi, Ruthvik; Rea, Catherine J; Sørensen, Benny; Urbanus, Rolf T; Østergaard, Henrik
VWF
发表日期：2026
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Challenging activity and signaling bias in tachykinin NK1 and NK2 receptors by truncated neuropeptides

截短神经肽对速激肽NK1和NK2受体活性和信号传导偏倚的挑战

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.108522
Petersen, Jacob E; Pavlovskyi, Artem; Madsen, Jesper J; Schwartz, Thue W; Frimurer, Thomas M; Olsen, Ole H
信号转导
NK1
发表日期：2025
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Molecular determinants of neuropeptide-mediated activation mechanisms in tachykinin NK1 and NK2 receptors.

速激肽 NK1 和 NK2 受体中神经肽介导的激活机制的分子决定因素

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2024.107948
Petersen Jacob E, Pavlovskyi Artem, Madsen Jesper J, Schwartz Thue W, Frimurer Thomas M, Olsen Ole H
神经科学
发表日期：2024
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Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures

通过对晶体结构进行整体精修，探索GPCR激活的机制基础

期刊:Protein Science
影响因子:5.2
doi:10.1002/pro.4456
Madsen, Jesper J; Ye, Libin; Frimurer, Thomas M; Olsen, Ole H
GPCR/Calcium/cAMP
发表日期：2022
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Allostery in Coagulation Factor VIIa Revealed by Ensemble Refinement of Crystallographic Structures

通过晶体结构整体精修揭示凝血因子VIIa的变构作用

期刊:Biophysical Journal
影响因子:3.1
doi:10.1016/j.bpj.2019.03.024
Sorensen, Anders B; Madsen, Jesper J; Frimurer, Thomas M; Overgaard, Michael T; Gandhi, Prafull S; Persson, Egon; Olsen, Ole H
发表日期：2019
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Engineering of a membrane-triggered activity switch in coagulation factor VIIa

凝血因子VIIa中膜触发活性开关的工程设计

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1618713114
Nielsen, Anders L; Sorensen, Anders B; Holmberg, Heidi L; Gandhi, Prafull S; Karlsson, Johan; Buchardt, Jens; Lamberth, Kasper; Kjelgaard-Hansen, Mads; Ley, Carsten Dan; Sørensen, Brit B; Ruf, Wolfram; Olsen, Ole H; Østergaard, Henrik
发表日期：2017
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ADAMDEC1 is a metzincin metalloprotease with dampened proteolytic activity

ADAMDEC1 是一种金属蛋白酶，其蛋白水解活性较低。

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M113.474536
Lund, Jacob; Olsen, Ole H; Sørensen, Esben S; Stennicke, Henning R; Petersen, Helle H; Overgaard, Michael T
AMD
ADA
发表日期：2013
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Engineering of substrate selectivity for tissue factor.factor VIIa complex signaling through protease-activated receptor 2.

通过蛋白酶激活受体 2 对组织因子-因子 VIIa 复合物信号传导的底物选择性进行工程改造

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M110.101030
Larsen Katrine S, Ostergaard Henrik, Olsen Ole H, Bjelke Jais R, Ruf Wolfram, Petersen Lars C
信号转导
发表日期：2010
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Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity

Ca2+诱导内源性因子VIIa活性增强的机制

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M800841200
Bjelke, Jais R; Olsen, Ole H; Fodje, Michel; Svensson, L Anders; Bang, Susanne; Bolt, Gert; Kragelund, Birthe B; Persson, Egon
发表日期：2008
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Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa

改造人凝血因子VIIa的底物和抑制剂特异性

期刊:Biochemical Journal
影响因子:4.3
doi:10.1042/BJ20061901
Larsen, Katrine S; Østergaard, Henrik; Bjelke, Jais R; Olsen, Ole H; Rasmussen, Hanne B; Christensen, Leif; Kragelund, Birthe B; Stennicke, Henning R
发表日期：2007
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