日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Designing allosteric modulators to change GPCR G protein subtype selectivity

设计变构调节剂以改变GPCR G蛋白亚型选择性

Moore, Madelyn N; Person, Kelsey L; Robleto, Valeria L; Alwin, Abigail R; Krusemark, Campbell L; Foster, Noah; Ray, Caroline; Inoue, Asuka; Jackson, Michael R; Sheedlo, Michael J; Barak, Lawrence S; Marron Fernandez de Velasco, Ezequiel; Olson, Steven H; Slosky, Lauren M

Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain.

神经降压素受体 1 的 Arrestin 偏向性变构调节剂可缓解急性和慢性疼痛

Guo Ran, Chen Ouyang, Zhou Yang, Bang Sangsu, Chandra Sharat, Li Yize, Chen Gang, Xie Rou-Gang, He Wei, Xu Jing, Zhou Richard, Song Shaoyong, Person Kelsey L, Moore Madelyn N, Alwin Abigail R, Spasojevic Ivan, Jackson Michael R, Olson Steven H, Caron Marc G, Slosky Lauren M, Wetsel William C, Barak Lawrence S, Ji Ru-Rong

Tauopathy strains differentially replicate in vitro in the presence of mutant tau monomer

在突变tau单体存在的情况下,tau蛋白病菌株在体外复制能力存在差异。

Brown, Christine K; Frost, Matthew P; Holec, Sara A M; Seeley, William W; Grinberg, Lea T; Olson, Steven H; Woerman, Amanda L

Virtual Compound Screening for Discovery of Dopamine D1 Receptor Biased Allosteric Modulators

利用虚拟化合物筛选发现多巴胺D1受体偏向性变构调节剂

Zhou, Yang; Wetsel, William C; Olson, Steven H; Barak, Lawrence S

Structurally targeted mutagenesis identifies key residues supporting α-synuclein misfolding in multiple system atrophy

结构靶向诱变鉴定出导致多系统萎缩症中α-突触核蛋白错误折叠的关键残基

Reis, Patricia M; Holec, Sara Am; Ezeiruaku, Chimere; Frost, Matthew P; Brown, Christine K; Liu, Samantha L; Olson, Steven H; Woerman, Amanda L

Corrigendum: Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex

更正:通过靶向 eIF4F 复合物抑制冠状病毒 HCoV-OC43

Feng, Yongmei; Grotegut, Stefan; Jovanovic, Predrag; Gandin, Valentina; Olson, Steven H; Murad, Rabi; Beall, Anne; Colayco, Sharon; De-Jesus, Paul; Chanda, Sumit; English, Brian P; Singer, Robert H; Jackson, Michael; Topisirovic, Ivan; Ronai, Ze'ev A

Biased allosteric modulator of neurotensin receptor 1 reduces ethanol drinking and responses to ethanol administration in rodents

神经降压素受体1的偏向性变构调节剂可降低啮齿动物的乙醇摄入量和对乙醇给药的反应

Gereau, Graydon B; Zhou, Diana; Voorhies, Kalynn Van; Tyler, Ryan E; Campbell, Jeffrey; Murray, Jackson G; Alvarez-Pamir, Ali; Wykoff, Luke A; Companion, Michel A; Jackson, Michael R; Olson, Steven H; Barak, Lawrence S; Slosky, Lauren M; Vetreno, Ryan P; Besheer, Joyce; McElligott, Zoe A

β-arrestin-biased Allosteric Modulator of Neurotensin Receptor 1 Reduces Ethanol Drinking and Responses to Ethanol Administration in Rodents

β-arrestin偏向性神经降压素受体1变构调节剂可降低啮齿动物的乙醇摄入量和对乙醇给药的反应

Gereau, Graydon B; Zhou, Diana; Van Voorhies, Kalynn; Tyler, Ryan E; Campbell, Jeffrey; Murray, Jackson G; Alvarez-Pamir, Ali; Wykoff, Luke A; Companion, Michel A; Jackson, Michael R; Olson, Steven H; Barak, Lawrence S; Slosky, Lauren M; Vetreno, Ryan P; Besheer, Joyce; McElligott, Zoe A

Structurally targeted mutagenesis identifies key residues supporting α -synuclein misfolding in multiple system atrophy

结构靶向诱变鉴定出导致多系统萎缩症中α-突触核蛋白错误折叠的关键残基

Reis, Patricia M; Holec, Sara A M; Ezeiruaku, Chimere; Frost, Matthew P; Brown, Christine K; Liu, Samantha L; Olson, Steven H; Woerman, Amanda L

The E46K mutation modulates α-synuclein prion replication in transgenic mice

E46K突变调节转基因小鼠中α-突触核蛋白朊病毒的复制

Holec, Sara A M; Lee, Jisoo; Oehler, Abby; Batia, Lyn; Wiggins-Gamble, Aryanna; Lau, Jeffrey; Ooi, Felicia K; Merz, Gregory E; Wang, Man; Mordes, Daniel A; Olson, Steven H; Woerman, Amanda L