日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Paramount Importance of Core Conformational Changes for Heparin Allosteric Activation of Antithrombin

核心构象变化对肝素变构激活抗凝血酶至关重要

Izaguirre, Gonzalo; Swanson, Richard; Roth, Ryan; Gettins, Peter G W; Olson, Steven T

An in vitro Model System for Evaluating Remote Magnetic Nanoparticle Movement and Fibrinolysis

用于评估远程磁性纳米颗粒运动和纤维蛋白溶解的体外模型系统

Pernal, Sebastian P; Willis, Alexander J; Sabo, Michael E; Moore, Laura M; Olson, Steven T; Morris, Sean C; Creighton, Francis M; Engelhard, Herbert H

Cooperative Interactions of Three Hotspot Heparin Binding Residues Are Critical for Allosteric Activation of Antithrombin by Heparin

三个肝素结合热点残基的协同作用对于肝素对凝血酶的变构激活至关重要

Richard, Benjamin; Swanson, Richard; Izaguirre, Gonzalo; Olson, Steven T

Disease-causing mutations in the serpin antithrombin reveal a key domain critical for inhibiting protease activities

丝氨酸蛋白酶抑制剂抗凝血酶的致病突变揭示了一个对抑制蛋白酶活性至关重要的关键结构域。

Águila, Sonia; Izaguirre, Gonzalo; Martínez-Martínez, Irene; Vicente, Vicente; Olson, Steven T; Corral, Javier

Lipid oxidation inactivates the anticoagulant function of protein Z-dependent protease inhibitor (ZPI)

脂质氧化会使蛋白质 Z 依赖性蛋白酶抑制剂 (ZPI) 的抗凝血功能失活。

Huang, Xin; Liu, Baoxin; Wei, Yidong; Beyea, Ryan; Yan, Han; Olson, Steven T

Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance

抑制性丝氨酸蛋白酶抑制剂。对其折叠、聚合、调控和清除的新见解

Gettins, Peter G W; Olson, Steven T

Thermodynamic and kinetic characterization of the protein Z-dependent protease inhibitor (ZPI)-protein Z interaction reveals an unexpected role for ZPI Lys-239

对蛋白质 Z 依赖性蛋白酶抑制剂 (ZPI) 与蛋白质 Z 相互作用的热力学和动力学表征揭示了 ZPI Lys-239 的一个意想不到的作用

Huang, Xin; Zhou, Jian; Zhou, Aiwu; Olson, Steven T

Saturation Mutagenesis of the Antithrombin Reactive Center Loop P14 Residue Supports a Three-step Mechanism of Heparin Allosteric Activation Involving Intermediate and Fully Activated States

抗凝血酶反应中心环 P14 残基的饱和突变支持肝素变构激活的三步机制,该机制涉及中间激活态和完全激活态。

Roth, Ryan; Swanson, Richard; Izaguirre, Gonzalo; Bock, Susan C; Gettins, Peter G W; Olson, Steven T

Targeted mutagenesis of zebrafish antithrombin III triggers disseminated intravascular coagulation and thrombosis, revealing insight into function.

对斑马鱼抗凝血酶 III 进行靶向诱变可引发弥散性血管内凝血和血栓形成,从而揭示其功能

Liu Yang, Kretz Colin A, Maeder Morgan L, Richter Catherine E, Tsao Philip, Vo Andy H, Huarng Michael C, Rode Thomas, Hu Zhilian, Mehra Rohit, Olson Steven T, Joung J Keith, Shavit Jordan A

Conformational activation of antithrombin by heparin involves an altered exosite interaction with protease

肝素对凝血酶构象的激活涉及其与蛋白酶的外位点相互作用的改变

Izaguirre, Gonzalo; Aguila, Sonia; Qi, Lixin; Swanson, Richard; Roth, Ryan; Rezaie, Alireza R; Gettins, Peter G W; Olson, Steven T