日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.

CLCC1促进肝脏中性脂质通量和核孔复合物组装。

Mathiowetz Alyssa J, Meymand Emily S, Parlakgül Güneş, van Hilten Niek, Torres Emily F, Artico Leonardo L, Deol Kirandeep K, Lange Mike, Pang Stephany P, Doubravsky Cody E, Roberts Melissa A, Jorgens Danielle M, Zalpuri Reena, Kang Misun, Boone Casadora, Parks Brian W, Zhang Yaohuan, Morgens David W, Newman Emily Tso, Zhou Yingjiang, Talukdar Saswata, Grabe Michael, Ku Gregory, Levine Tim P, Arruda Ana Paula, Olzmann James A

Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity

通过靶向FSP1选择性地破坏肿瘤内调节性T细胞中的脂质过氧化物稳态,可增强肿瘤免疫力。

Castillo, Jesse Garcia; Silveria, Stephanie; Schirokauer, Leo; Sauquet, Antoine; Hung, Jessica; Jaworski, Grace; Hendricks, Joseph M; Sul, Hei Sook; Olzmann, James A; DuPage, Michel

Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis.

维生素 B2 代谢促进 FSP1 稳定性,防止铁死亡。

Deol Kirandeep K, Harris Cynthia A, Tomlinson Sydney J, Delaney Colin J, Al-Farhan Amr, Mathiowetz Alyssa J, Doubravsky Cody E, Pratt Derek A, Olzmann James A

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.

亮氨酸氨肽酶 LyLAP 能够使溶酶体降解膜蛋白。

Jain Aakriti, Heremans Isaac, Rademaker Gilles, Detomasi Tyler C, Rohweder Peter, Anderson Dashiell, Zhang Justin, Hernandez Grace A, Gupta Suprit, von Linde Teresa, Lange Mike, Spacci Martina, Luo Jiayi, Citron Y Rose, Olzmann James A, Dawson David W, Craik Charles S, Bommer Guido, Perera Rushika M, Zoncu Roberto

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis.

FSP1介导的脂滴质量控制可防止中性脂质过氧化和铁死亡。

Lange Mike, Wölk Michele, Li Vivian Wen, Doubravsky Cody E, Hendricks Joseph M, Kato Shunji, Otoki Yurika, Styler Benjamin, Johnson Sean L, Harris Cynthia A, Nakagawa Kiyotaka, Snodgrass Isabel F, Kim Dohee, Newman John W, Fedorova Maria, Olzmann James A

Hijacking Extracellular Targeted Protein Degrader-Drug Conjugates for Enhanced Drug Delivery

利用细胞外靶向蛋白降解剂-药物偶联物增强药物递送

Fangzhu Zhao ,Yan Wu ,Kaitlin Schaefer ,Yun Zhang ,Kun Miao ,Zi Yao ,Snehal D Ganjave ,Kaan Kumru ,Trenton M Peters-Clarke ,Alex Inague ,James A Olzmann ,Kevin K Leung ,James A Wells

DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders

基于DCAF16的共价降解基团用于降解剂的模块化设计

Orr, Lauren M; Tomlinson, Sydney J; Grupe, Hannah R; Lim, Melissa; Ho, Emily; Yilmaz, Halime; Zhou, Grace; Leon, Barbara; Olzmann, James A; Nomura, Daniel K

Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1.

共晶结构揭示了 FSEN1 抑制 FSP1 的机制

Zhang Sitao, Megarioti Amalia H, Hendricks Joseph M, Zhou Junshu, Sun Qingxiang, Jia Da, Olzmann James A

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis

FSP1 介导的脂滴质量控制可防止中性脂质过氧化和铁死亡

Mike Lange, Michele Wölk, Cody E Doubravsky, Joseph M Hendricks, Shunji Kato, Yurika Otoki, Benjamin Styler, Kiyotaka Nakagawa, Maria Fedorova, James A Olzmann

Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity

通过靶向FSP1选择性地破坏肿瘤内调节性T细胞中的脂质过氧化物稳态,可增强肿瘤免疫力。

Castillo, Jesse Garcia; Silveria, Stephanie; Sauquet, Antoine; Schirokauer, Leo; Hendricks, Joseph; Sul, Hei Sook; Olzmann, James A; DuPage, Michel