Onal Melda相关文献与解析，生知库 | 链接生命科学的每一步

Onal, Melda; Nookaew, Intawat; Resende-Coelho, Ana; Reyes-Castro, Olivia; Marques-Carvalho, Adriana; Gatrell, Landon; Kurilung, Alongkorn; James, Alicen; Warren, Aaron; Kim, Ha-Neui; Xiong, Jinhu; O'Brien, Charles A; Almeida, Maria

Mouse

发表日期：2025

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Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength.

成骨细胞谱系细胞中自噬主调节因子Tfeb的升高可增加骨量和骨强度。

期刊:JCI Insight

影响因子:6.1

doi:10.1172/jci.insight.191688

James Alicen, Hendrixson James A, Kadhim Ilham, Marques-Carvalho Adriana, Laster Jacob, Crawford Julie, Thostenson Jeff, Wanchai Visanu, Sato Amy Y, Nookaew Intawat, Xiong Jinhu, Almeida Maria, Onal Melda

Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness.

成骨细胞系细胞中的线粒体氧化应激或自噬减少不足以模拟衰老对骨骼力学反应性的有害影响

期刊:Aging-Us

影响因子:3.9

doi:10.18632/aging.206213

Resende-Coelho Ana, Ali Md Mohsin, James Alicen, Warren Aaron, Gatrell Landon, Kadhim Ilham, Fu Qiang, Xiong Jinhu, Onal Melda, Almeida Maria

TFEB-mediated autophagy stimulation as an anabolic strategy for bone: insights from TFEB activation in the osteoblast lineage

TFEB介导的自噬刺激作为骨骼合成代谢策略：来自成骨细胞谱系中TFEB激活的启示

期刊:Autophagy Reports

影响因子:

doi:10.1080/27694127.2025.2596422

A new Col1a1 conditional knock-in mouse model to study osteogenesis imperfecta.

一种用于研究成骨不全症的新型 Col1a1 条件性敲入小鼠模型

期刊:Journal of Bone and Mineral Research

影响因子:5.9

doi:10.1093/jbmr/zjae189

Dimori Milena, Toulany Mahtab, Sultana Lira Samia, Onal Melda, Thostenson Jeff D, Carroll John L, O'Brien Charles A, Morello Roy

CRISPR activation of Tfeb , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength

在成骨细胞谱系细胞中，通过 CRISPR 技术激活 Tfeb（一种自噬和溶酶体生物合成的关键调节因子）可增加骨量和骨强度。

期刊:

影响因子:

doi:10.1101/2024.09.26.615175

James, Alicen; Hendrixson, James; Kadhim, Ilham; Marques-Carvalho, Adriana; Laster, Jacob; Crawford, Julie; Thostenson, Jeff; Sato, Amy; Almeida, Maria; Onal, Melda

Novel methods for the generation of genetically engineered animal models

构建基因工程动物模型的新方法

期刊:

影响因子:

doi:10.1016/j.bone.2022.116612

Cassidy, Annelise; Onal, Melda; Pelletier, Stephane

发表日期：2023

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Effective CRISPR interference of an endogenous gene via a single transgene in mice

利用小鼠体内单个转基因有效干扰内源基因的CRISPR技术

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-019-53611-6

MacLeod, Ryan S; Cawley, Keisha M; Gubrij, Igor; Nookaew, Intawat; Onal, Melda; O'Brien, Charles A

发表日期：2019

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A Control Region Near the Fibroblast Growth Factor 23 Gene Mediates Response to Phosphate, 1,25(OH)2D3, and LPS In Vivo

成纤维细胞生长因子23基因附近的控制区介导体内对磷酸盐、1,25(OH)2D3和LPS的反应

期刊:Endocrinology

影响因子:3.3

doi:10.1210/en.2019-00622

Lee, Seong Min; Carlson, Alex H; Onal, Melda; Benkusky, Nancy A; Meyer, Mark B; Pike, J Wesley

The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights

维生素D受体：当代基因组学方法揭示了新的基础和转化见解

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI88887

Pike, J Wesley; Meyer, Mark B; Lee, Seong-Min; Onal, Melda; Benkusky, Nancy A

信号转导

发表日期：2017

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The Aging Landscape by scRNAseq of Mesenchymal Lineage Cells in Mouse Bone

利用单细胞RNA测序技术分析小鼠骨骼间充质谱系细胞的衰老图谱

Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength.

成骨细胞谱系细胞中自噬主调节因子Tfeb的升高可增加骨量和骨强度。

Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness.

成骨细胞系细胞中的线粒体氧化应激或自噬减少不足以模拟衰老对骨骼力学反应性的有害影响

TFEB-mediated autophagy stimulation as an anabolic strategy for bone: insights from TFEB activation in the osteoblast lineage

TFEB介导的自噬刺激作为骨骼合成代谢策略：来自成骨细胞谱系中TFEB激活的启示

A new Col1a1 conditional knock-in mouse model to study osteogenesis imperfecta.

一种用于研究成骨不全症的新型 Col1a1 条件性敲入小鼠模型

CRISPR activation of Tfeb , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength

在成骨细胞谱系细胞中，通过 CRISPR 技术激活 Tfeb（一种自噬和溶酶体生物合成的关键调节因子）可增加骨量和骨强度。

Novel methods for the generation of genetically engineered animal models

构建基因工程动物模型的新方法

Effective CRISPR interference of an endogenous gene via a single transgene in mice

利用小鼠体内单个转基因有效干扰内源基因的CRISPR技术

A Control Region Near the Fibroblast Growth Factor 23 Gene Mediates Response to Phosphate, 1,25(OH)2D3, and LPS In Vivo

成纤维细胞生长因子23基因附近的控制区介导体内对磷酸盐、1,25(OH)2D3和LPS的反应

The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights

维生素D受体：当代基因组学方法揭示了新的基础和转化见解