日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950.

TH5487 专门针对对 MCC950 耐药的 FCAS 患者中的 NLRP3。

Lackner Angela, Picucci Sofia I, Jiang Wenjin, Onyuru Janset, Campos Melissa, Cabral Julia E, Leonidas Lemuel, Macapagal Alijah, Lee Hannah, Henriquez Valerie, Wang Karen, Xu Huilin, Qiu Yanfei, Albrecht Lauren V, Hoffman Hal M, McNulty Reginald

Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation

利用反义寡核苷酸调控NLRP3剪接以控制病理性炎症

Klein, Roni; Onyuru, Janset; Centa, Jessica L; Viera, Estela M; Putnam, Christopher D; Hoffman, Hal M; Hastings, Michelle L

TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950

TH5487 特异性靶向 MCC950 耐药的 FCAS 患者中的 NLRP3。

Lackner, Angela; Leonidas, Lemuel; Macapagal, Alijah; Lee, Hannah; Xu, Huilin; Qiu, Yanfei; Campos, Melissa; Cabral, Julia E; Onyuru, Janset; Kulkarni, Sanika; Albrecht, Lauren V; Hoffman, Hal M; McNulty, Reginald

Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome

牛磺酸水平的兴奋性升高可通过抑制NLRP3炎症小体来抑制炎症衰老。

Guan, Chenyang; Ryu, Seungjin; Dong, Mingze; Youm, Yun-Hee; Mohanty, Subhasis; Maeda, Rae; Orliaguet, Lucie; Kim, Hee-Hoon; Dlugos, Tamara; Smith, Steven R; Ravussin, Eric; Onyuru, Janset; Wang, Andrew; Shaw, Albert C; Hoffman, Hal M; Kluger, Yuval; Sugiura, Yuki; Dixit, Vishwa Deep

Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation.

利用反义寡核苷酸调节 NLRP3 剪接以控制病理性炎症

Klein Roni, Onyuru Janset, Centa Jessica L, Viera Estela M, Duelli Fox J, Putnam Christopher D, Hoffman Hal M, Hastings Michelle L

BRP39 Regulates Neutrophil Recruitment in NLRP3 Inflammasome-Induced Liver Inflammation

BRP39 调节 NLRP3 炎症小体诱导的肝脏炎症中的中性粒细胞募集

Lin Kui ,Andrea D Kim ,Janset Onyuru ,Hal M Hoffman ,Ariel E Feldstein

NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis

中性粒细胞中NLRP3的激活会诱发致命的自身炎症、肝脏炎症和纤维化。

Kaufmann, Benedikt; Leszczynska, Aleksandra; Reca, Agustina; Booshehri, Laela M; Onyuru, Janset; Tan, ZheHao; Wree, Alexander; Friess, Helmut; Hartmann, Daniel; Papouchado, Bettina; Broderick, Lori; Hoffman, Hal M; Croker, Ben A; Zhu, Yanfang Peipei; Feldstein, Ariel E

Cell Death in Liver Disease and Liver Surgery

肝病和肝手术中的细胞死亡

Stoess, Christian; Choi, Yeon-Kyung; Onyuru, Janset; Friess, Helmut; Hoffman, Hal M; Hartmann, Daniel; Feldstein, Ariel E

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

氧化DNA片段通过mPTP和VDAC依赖性通道离开线粒体,激活NLRP3炎症小体和干扰素信号通路。

Hongxu Xian ,Kosuke Watari ,Elsa Sanchez-Lopez ,Joseph Offenberger ,Janset Onyuru ,Harini Sampath ,Wei Ying ,Hal M Hoffman ,Gerald S Shadel ,Michael Karin

NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis

中性粒细胞中NLRP3的激活会诱发致命的自身炎症、肝脏炎症和纤维化。

Benedikt Kaufmann ,Aleksandra Leszczynska ,Agustina Reca ,Laela M Booshehri ,Janset Onyuru ,ZheHao Tan ,Alexander Wree ,Helmut Friess ,Daniel Hartmann ,Bettina Papouchado ,Lori Broderick ,Hal M Hoffman ,Ben A Croker ,Yanfang Peipei Zhu # ,Ariel E Feldstein #