日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Protein domain characterization reveals human MIC60 tolerates loss of helical bundle domain

蛋白质结构域表征表明,人源MIC60能够耐受螺旋束结构域的缺失。

Rockfield, Stephanie M; Venkataraman, Krishnan; Wu, Chih-Hsuan; Wakefield, Randall; Wu, Alan; Budhraja, Amit; Rodriguez-Enriquez, Ricardo; Khalighifar, Ali; Robinson, Camenzind G; Li, Cai; Carisey, Alexandre F; Opferman, Joseph Thomas

Venetoclax plus gilteritinib is effective in preclinical models of FLT3-mutant BCL11B-a lineage-ambiguous leukemia

Venetoclax联合gilteritinib在FLT3突变型BCL11B-a谱系不明确白血病的临床前模型中有效。

Lindsey E Montefiori,Ilaria Iacobucci,Qingsong Gao,Jamila Moore,William C Wright,Huimei Wei,Pradyumna Baviskar,Surbhi Sona,Hongjian Jin,Amit Budhraja,Josi Lott,Qi Zhang Tatarata,Zhongshan Cheng,Tanya Khan,Emily A Backhaus Wagner,Melissa Johnson,Cyrus M Mehr,Burgess Freeman,Laura Janke,Torsten Haferlach,Paul Geeleher,Paul E Mead,Marina Konopleva,Joseph T Opferman,Charles G Mullighan

DNTT-mediated DNA damage response drives inotuzumab ozogamicin resistance in B-cell acute lymphoblastic leukemia

DNTT介导的DNA损伤反应驱动B细胞急性淋巴细胞白血病对inotuzumab ozogamicin产生耐药性

Carolin S Escherich ,Takaya Moriyama ,Zhenhua Li ,Yu-Chih Hsiao ,Wenjian Yang ,Yizhen Li ,Noemi Reyes ,Megan Walker ,Amit Budhraja ,Sheetal Bhatara ,Ernesto Diaz-Flores ,Wendy Stock ,Elisabeth Paietta ,Marina Y Konopleva ,Steven M Kornblau ,Mark R Litzow ,Hiroto Inaba ,Ching-Hon Pui ,Joseph T Opferman ,Mignon L Loh ,Jiyang Yu ,Maureen M O'Brien ,William E Evans ,Jun J Yang

The BCL-2 protein family: from discovery to drug development

BCL-2蛋白家族:从发现到药物研发

Croce, Carlo M; Vaux, David; Strasser, Andreas; Opferman, Joseph T; Czabotar, Peter E; Fesik, Stephen W

Neutrophils negatively control IL-17A-producing γδ T cell frequencies in a contact-dependent manner under physiological conditions

在生理条件下,中性粒细胞以接触依赖的方式负向调控产生IL-17A的γδ T细胞的频率。

Yu, Xinhua; Yue, Xiaoyang; Tchudjin Magatsin, Junie D; Marwitz, Sebastian; Behrends, Jochen; Goldmann, Torsten; Opferman, Joseph T; Kasper, Brigitte; Petersen, Frank

Mitochondrial proteostasis regulated by CRL5(Ozz) and Alix modulates skeletal muscle metabolism and fiber type.

线粒体蛋白稳态受 CRL5(Ozz) 和 Alix 调控,从而调节骨骼肌代谢和纤维类型。

Campos Yvan, Palacios Gustavo, Gomero Elida, van de Vlekkert Diantha, Venkataraman Krishnan, John Jaison, Weesner Jason Andrew, Wakefield Randall, Qiu Xiaohui, Rodriguez-Enriquez Ricardo, Rockfield Stephanie, Demmers Jeroen, Opferman Joseph T, Robinson Cam, Khairy Khaled, Bertorini Tulio, Grosveld Gerard C, d'Azzo Alessandra

Therapy resistance in AML is mediated by cytoplasmic sequestration of the transcriptional repressor IRF2BP2

急性髓系白血病(AML)的治疗耐药性是由转录抑制因子IRF2BP2的胞质隔离介导的。

Althoff, Mark J; Minhajuddin, Mohd; Stevens, Brett M; Gillen, Austin E; Gipson, Stephanie; Patel, Sweta B; Shelton, Ian T; Miller, Regan; Vujovic, Ana; Krug, Anna; Young, Tracy; Showers, William M; Dzieciatkowska, Monika; Stephenson, Daniel; Tyagi, Anit; Ellegast, Jana M; Wright, Tristen; Stegmaier, Kimberly; Opferman, Joseph T; D'Alessandro, Angelo; Smith, Clayton A; Jordan, Craig T

Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1

抗凋亡蛋白MCL-1通过与ACSL1相互作用促进长链脂肪酸氧化

Tristen Wright ,Meghan E Turnis ,Christy R Grace ,Xiao Li ,Lauren A Brakefield ,Yong-Dong Wang ,Haiyan Xu ,Ewa Kaminska ,Leslie K Climer ,Tresor O Mukiza ,Chi-Lun Chang ,Tudor Moldoveanu ,Joseph T Opferman

Correction: Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications

更正:Mcl-1赋予Her2阳性乳腺癌细胞对缺氧的保护作用:治疗意义

Bashari, Muhammad Hasan; Fan, Fengjuan; Vallet, Sonia; Sattler, Martin; Arn, Melissa; Luckner-Minden, Claudia; Schulze-Bergkamen, Henning; Zörnig, Inka; Marme, Frederik; Schneeweiss, Andreas; Cardone, Michael H; Opferman, Joseph T; Jäger, Dirk; Podar, Klaus

Genetic ablation of Immt induces a lethal disruption of the MICOS complex

Immt 基因消融可导致 MICOS 复合物的致命破坏

Stephanie M Rockfield, Meghan E Turnis, Ricardo Rodriguez-Enriquez, Madhavi Bathina, Seng Kah Ng, Nathan Kurtz, Nathalie Becerra Mora, Stephane Pelletier, Camenzind G Robinson, Peter Vogel, Joseph T Opferman