日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Synergistic MAPT mutations as a platform to uncover modifiers of tau pathogenesis

协同MAPT突变作为揭示tau蛋白致病机制修饰因子的平台

Bryan, Miles R; Almeida, Michael; Pellegrino, Kyle; Opland, Carli; Paulakonis, Ethan; McGillion-Moore, Jake; Trzeciakiewicz, Hanna; King, Diamond; Tian, Xu; Tseng, Jui-Heng; Schisler, Jonathan; Brown, Nicholas G; Bahr, Ben; Cohen, Todd J

Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity

胱天蛋白酶-3活性依赖性tau裂解促进神经元功能障碍和突触毒性

Carli K Opland, Miles R Bryan, Braxton Harris, Jake McGillion-Moore, Xu Tian, Youjun Chen, Michelle S Itano, Graham H Diering, Rick B Meeker, Todd J Cohen

Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility

人类进化而来的调控元件调节与皮层扩张和神经发育疾病易感性相关的基因

Won, Hyejung; Huang, Jerry; Opland, Carli K; Hartl, Chris L; Geschwind, Daniel H

A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation

妊娠中期人类新皮层发育的单细胞转录组图谱

Polioudakis, Damon; de la Torre-Ubieta, Luis; Langerman, Justin; Elkins, Andrew G; Shi, Xu; Stein, Jason L; Vuong, Celine K; Nichterwitz, Susanne; Gevorgian, Melinda; Opland, Carli K; Lu, Daning; Connell, William; Ruzzo, Elizabeth K; Lowe, Jennifer K; Hadzic, Tarik; Hinz, Flora I; Sabri, Shan; Lowry, William E; Gerstein, Mark B; Plath, Kathrin; Geschwind, Daniel H

The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis

人类皮质神经发生过程中开放染色质的动态景观

Luis de la Torre-Ubieta, Jason L Stein, Hyejung Won, Carli K Opland, Dan Liang, Daning Lu, Daniel H Geschwind

Chromosome conformation elucidates regulatory relationships in developing human brain

染色体构象阐明了人类大脑发育过程中的调控关系

Won, Hyejung; de la Torre-Ubieta, Luis; Stein, Jason L; Parikshak, Neelroop N; Huang, Jerry; Opland, Carli K; Gandal, Michael J; Sutton, Gavin J; Hormozdiari, Farhad; Lu, Daning; Lee, Changhoon; Eskin, Eleazar; Voineagu, Irina; Ernst, Jason; Geschwind, Daniel H

Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity

伏隔核中的神经肽Y活性调节摄食行为和神经元活动。

van den Heuvel, José K; Furman, Kara; Gumbs, Myrtille C R; Eggels, Leslie; Opland, Darren M; Land, Benjamin B; Kolk, Sharon M; Narayanan, Nandakumar S; Fliers, Eric; Kalsbeek, Andries; DiLeone, Ralph J; la Fleur, Susanne E

The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes

胰岛雌激素受体α受高血糖诱导,并能抵抗氧化应激诱导的胰岛素缺乏型糖尿病。

Kilic, Gamze; Alvarez-Mercado, Ana I; Zarrouki, Bader; Opland, Darren; Liew, Chong Wee; Alonso, Laura C; Myers, Martin G Jr; Jonas, Jean-Christophe; Poitout, Vincent; Kulkarni, Rohit N; Mauvais-Jarvis, Franck

Loss of neurotensin receptor-1 disrupts the control of the mesolimbic dopamine system by leptin and promotes hedonic feeding and obesity

神经降压素受体-1的缺失会破坏瘦素对中脑边缘多巴胺系统的调控,从而促进享乐性进食和肥胖。

Opland, Darren; Sutton, Amy; Woodworth, Hillary; Brown, Juliette; Bugescu, Raluca; Garcia, Adriana; Christensen, Lyndsay; Rhodes, Christopher; Myers, Martin Jr; Leinninger, Gina

Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance

瘦素通过神经降压素神经元发挥作用,控制食欲素、中脑边缘多巴胺系统和能量平衡。

Leinninger, Gina M; Opland, Darren M; Jo, Young-Hwan; Faouzi, Miro; Christensen, Lyndsay; Cappellucci, Laura A; Rhodes, Christopher J; Gnegy, Margaret E; Becker, Jill B; Pothos, Emmanuel N; Seasholtz, Audrey F; Thompson, Robert C; Myers, Martin G Jr