日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Characterization of Novel Sigma Receptor Ligands Derived from Multicomponent Reactions as Efficacious Treatments for Neuropathic Pain

表征源自多组分反应的新型σ受体配体作为治疗神经性疼痛的有效方法

Shinouchi, Ryosuke; Turgutalp, Bengisu; Ople, Rohini S; Eans, Shainnel O; Williams, Ashai K; Hammond, Haylee R; Varadi, Andras; Dardashti, Rebecca Notis; Majumdar, Susruta; McLaughlin, Jay P

Total synthesis and biological activity of "carbamorphine": O-to-CH(2) replacement in the E-ring of the morphine core structure.

“卡巴吗啡”的全合成及生物活性:吗啡核心结构E环中的O-到-CH(2)取代

Akiyama Sota, Ople Rohini S, Kremsmair Alexander, Ramos-Gonzalez Nokomis, Nedungadan Thomas, Kennedy Brandon J, Appourchaux Kevin, Eans Shainnel O, Tsai Bowen A, Kraml Christina, Huang Xi-Ping, McLaughlin Jay P, Majumdar Susruta, Sarpong Richmond

Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models

Oxa-Iboga 生物碱在动物模型中不具有心脏风险,并能干扰阿片类药物的使用

Václav Havel #, Andrew C Kruegel #, Benjamin Bechand #, Scot McIntosh, Leia Stallings, Alana Hodges, Madalee G Wulf, Mel Nelson, Amanda Hunkele, Michael Ansonoff, John E Pintar, Christopher Hwu, Rohini S Ople, Najah Abi-Gerges, Saheem A Zaidi, Vsevolod Katritch, Mu Yang, Jonathan A Javitch, Susruta

Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR

配体与μ阿片受体钠位点的水分子相互作用介导的信号调控

Ople, Rohini S; Ramos-Gonzalez, Nokomis; Li, Qiongyu; Sobecks, Briana L; Aydin, Deniz; Powers, Alexander S; Faouzi, Abdelfattah; Polacco, Benjamin J; Bernhard, Sarah M; Appourchaux, Kevin; Sribhashyam, Sashrik; Eans, Shainnel O; Tsai, Bowen A; Dror, Ron O; Varga, Balazs R; Wang, Haoqing; Hüttenhain, Ruth; McLaughlin, Jay P; Majumdar, Susruta

A phase 1 open label study to assess the human mass balance and metabolite profile of (14)C-fosmanogepix, a novel Gwt-1 inhibitor in healthy male participants

一项 1 期开放标签研究,旨在评估新型 Gwt-1 抑制剂 (14)C-fosmanogepix 在健康男性受试者中的人体质量平衡和代谢物谱。

Hodges, Michael R; Ople, Eric; Evans, Philip; Pantophlet, A J Andre; Richardson, Jessica; Williams, Dylan; Tripathy, Sakambari; Tawadrous, Margaret; Jakate, Abhijeet

Phase 1 drug-drug interaction study to assess the effect of CYP3A4 inhibition and pan-CYP induction on the pharmacokinetics and safety of fosmanogepix in healthy participants

一项评估CYP3A4抑制和泛CYP诱导对健康受试者福斯马诺吉匹(fosmanogepix)药代动力学和安全性影响的I期药物相互作用研究

Hodges, Michael R; van Marle, Sjoerd; Kramer, William G; Ople, Eric; Tawadrous, Margaret; Jakate, Abhijeet

Complex haploinsufficiency in pluripotent cells yields somatic cells with DNA methylation abnormalities and pluripotency induction defects

多能细胞中复杂的单倍体功能不全会导致体细胞出现DNA甲基化异常和多能性诱导缺陷。

Lasry, Rachel; Maoz, Noam; Cheng, Albert W; Yom Tov, Nataly; Kulenkampff, Elisabeth; Azagury, Meir; Yang, Hui; Ople, Cora; Markoulaki, Styliani; Faddah, Dina A; Makedonski, Kirill; Orzech, Dana; Sabag, Ofra; Jaenisch, Rudolf; Buganim, Yosef

Safety and Pharmacokinetics of Intravenous and Oral Fosmanogepix, a First-in-Class Antifungal Agent, in Healthy Volunteers

在健康志愿者中静脉注射和口服福斯马诺吉匹(一种首创抗真菌药物)的安全性和药代动力学

Hodges, Michael R; Ople, Eric; Wedel, Pamela; Shaw, Karen J; Jakate, Abhijeet; Kramer, William G; Marle, Sjoerd van; van Hoogdalem, Ewoud-Jan; Tawadrous, Margaret

Clinical Efficacy and Safety of a Novel Antifungal, Fosmanogepix, in Patients with Candidemia Caused by Candida auris: Results from a Phase 2 Trial

新型抗真菌药物福斯马诺吉匹治疗耳念珠菌血症患者的临床疗效和安全性:一项 II 期试验的结果

Vazquez, Jose A; Pappas, Peter G; Boffard, Kenneth; Paruk, Fathima; Bien, Paul A; Tawadrous, Margaret; Ople, Eric; Wedel, Pamela; Oborska, Iwona; Hodges, Michael R