日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Epigenetic consequences of DNA damage

DNA损伤的表观遗传后果

Paull, Tanya T; Opresko, Patricia L

Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition.

小叶乳腺癌中 MDC1 相互作用的改变和 DNA 修复功能障碍赋予了其对 PARP 抑制剂的敏感性。

Sottnik Joseph L, Shackleford Madeleine T, Nesiba Camryn S, Richer Amanda L, Fleischmann Zoe, Swartz Jordan M, Rowland Carmen E, Musick Maggie, Fu Rui, Myler Logan R, Opresko Patricia L, Mehrotra Sanjana, Sokol Ethan S, Hesselberth Jay R, Diamond Jennifer R, Sikora Matthew J

Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer.

氧化应激诱导的端粒不稳定导致癌症中T细胞功能障碍。

Rivadeneira Dayana B, Thosar Sanjana, Quann Kevin, Gunn William G, Dean Victoria G, Xie Bingxian, Parise Angelina, McGovern Andrew C, Spahr Kellie, Lontos Konstantinos, Barnes Ryan P, Bruchez Marcel P, Opresko Patricia L, Delgoffe Greg M

Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions

全面的 RAD51C 卵巢癌变异分析揭示了同源重组和复制功能之间的关联

Rein, Hayley L; Rawal, Yashpal; Palovcak-Lightbourn, Anna L; Ganesan, Gayatri S; Parker, Phoebe S; Russell, Reagan; Darrah, Kristie E; Afsar, Mohammad; Sullivan, Meghan R; Hengel, Sarah R; Radke, Marc R; Opresko, Patricia L; Yanowitz, Judith L; Greene, Eric C; Lee, Jung-Min; Domchek, Susan M; Swisher, Elizabeth M; Olsen, Shaun K; Sung, Patrick; Bernstein, Kara A

Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex

治疗性6-硫代脱氧鸟苷通过诱导非生产性停滞端粒酶复合物来抑制癌细胞中的端粒延长。

Sanford, Samantha L; Badstübner, Mareike; Gerber, Michael; Mannherz, William; Lampl, Noah; Dannenberg, Rachel; Hinchie, Angela; Schaich, Matthew A; Myong, Sua; Hedglin, Mark; Agarwal, Suneet; Alder, Jonathan K; Stone, Michael D; Opresko, Patricia L

OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts

OGG1 和 MUTYH 修复活性促进人类成纤维细胞中端粒 8-氧鸟嘌呤诱导的衰老

Mariarosaria De Rosa, Ryan P Barnes #, Ariana C Detwiler #, Prasanth R Nyalapatla, Peter Wipf, Patricia L Opresko

Oxidative Stress and DNA Damage at Telomeres

端粒处的氧化应激和DNA损伤

Opresko, Patricia L; Sanford, Samantha L; De Rosa, Mariarosaria

Oxidative Base Damage to Telomeres Sensitizes Cancer Cells to ATR Inhibition

端粒氧化碱基损伤使癌细胞对ATR抑制剂更加敏感

Garbouchian, Alex; Moreno, Natalia Cestari; Dey, Aninda; Opresko, Patricia; Barnes, Ryan

Human ribomes reveal DNA-embedded ribonucleotides as a new type of epigenetic mark

人类核糖体组揭示了DNA嵌入的核糖核苷酸是一种新型的表观遗传标记。

Kundnani, Deepali L; Yang, Taehwan; Channagiri, Tejasvi; Xu, Penghao; Lee, Yeunsoo; Sun, Mo; Martinez-Figueroa, Francisco; Randhawa, Supreet; Gogate, Ashlesha; Jeon, Youngkyu; Marsili, Stefania; Newnam, Gary; Lu, Yilin; Park, Vivian S; Tao, Sijia; Ling, Justin A; Schinazi, Raymond F; Pursell, Zachary F; Mohammed, Abdulmelik; Opresko, Patricia L; Freudenthal, Bret D; Kim, Baek; Yi, Soojin V; Jonoska, Nataša; Storici, Francesca

Chemotherapeutic 6-thio-2'-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex

化疗药物6-硫代-2'-脱氧鸟苷通过诱导形成非生产性端粒结合端粒酶复合物,选择性地靶向并抑制端粒酶。

Sanford, Samantha L; Badstübner, Mareike; Gerber, Michael; Mannherz, William; Lampl, Noah; Dannenberg, Rachel; Hinchie, Angela; Schaich, Matthew A; Myong, Sua; Hedglin, Mark; Agarwal, Suneet; Alder, Jonathan K; Stone, Michael D; Opresko, Patricia L