Ordazzo相关文献与解析，生知库 | 链接生命科学的每一步

MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome mice

MCT1 依赖性能量衰竭和神经炎症是 Wolfram 综合征小鼠视神经退化的原因

Greta Rossi, Gabriele Ordazzo, Niccolò N Vanni, Valerio Castoldi, Angelo Iannielli, Dario Di Silvestre, Edoardo Bellini, Letizia Bernardo, Serena G Giannelli, Mirko Luoni, Sharon Muggeo, Letizia Leocani, PierLuigi Mauri, Vania Broccoli

神经

神经炎症

Immunology/Inflammation

发表日期：2023

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A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor development

SOX2基因工程改造的表观遗传沉默因子抑制胶质母细胞瘤的基因表达程序，从而抑制肿瘤发展。

期刊:Science Advances

影响因子:11.7

doi:10.1126/sciadv.abn3986

Valerio Benedetti ，Federica Banfi ，Mattia Zaghi ，Raquel Moll-Diaz ，Luca Massimino ，Laura Argelich ，Edoardo Bellini ，Simone Bido ，Sharon Muggeo ，Gabriele Ordazzo ，Giuseppina Mastrototaro ，Matteo Moneta ，Alessandro Sessa ，Vania Broccoli

Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications

通过 SNCA 增殖的一组新的同源 iPSC 系衍生的多巴胺能神经元中的天然和种子突触核蛋白聚集和相关细胞功能障碍进行建模

期刊:Cell Death & Disease

影响因子:8.1

doi:10.1038/s41419-022-05330-6

Angelo Iannielli #, Mirko Luoni #, Serena Gea Giannelli #, Rosangela Ferese, Gabriele Ordazzo, Matteo Fossati, Andrea Raimondi, Felipe Opazo, Olga Corti, Jochen H M Prehn, Stefano Gambardella, Ronald Melki, Vania Broccoli

Author Correction: Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity

作者更正：小胶质细胞特异性α-突触核蛋白过度表达会导致吞噬细胞耗竭和氧化毒性，进而引发严重的多巴胺能神经退行性变。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-021-27737-z

Bido, Simone; Muggeo, Sharon; Massimino, Luca; Marzi, Matteo Jacopo; Giannelli, Serena Gea; Melacini, Elena; Nannoni, Melania; Gambarè, Diana; Bellini, Edoardo; Ordazzo, Gabriele; Rossi, Greta; Maffezzini, Camilla; Iannelli, Angelo; Luoni, Mirko; Bacigaluppi, Marco; Gregori, Silvia; Nicassio, Francesco; Broccoli, Vania

Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity

小胶质细胞特异性 α-突触核蛋白过度表达通过吞噬细胞衰竭和氧化毒性导致严重的多巴胺能神经变性

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-021-26519-x

Simone Bido, Sharon Muggeo, Luca Massimino, Matteo Jacopo Marzi, Serena Gea Giannelli, Elena Melacini, Melania Nannoni, Diana Gambarè, Edoardo Bellini, Gabriele Ordazzo, Greta Rossi, Camilla Maffezzini, Angelo Iannelli, Mirko Luoni, Marco Bacigaluppi, Silvia Gregori, Francesco Nicassio, Vania Brocco

AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy

AAV-PHP.B 介导的小鼠神经系统中的全球性表达使 GBA1 基因疗法能够广泛预防突触核蛋白病

期刊:Molecular Therapy

影响因子:12.1

doi:10.1016/j.ymthe.2017.08.004

Giuseppe Morabito, Serena G Giannelli, Gabriele Ordazzo, Simone Bido, Valerio Castoldi, Marzia Indrigo, Tommaso Cabassi, Stefano Cattaneo, Mirko Luoni, Cinzia Cancellieri, Alessandro Sessa, Marco Bacigaluppi, Stefano Taverna, Letizia Leocani, José L Lanciego, Vania Broccoli

Performance of two modified two-tier algorithms for the serologic diagnosis of Lyme disease

两种改进的两级算法在莱姆病血清学诊断中的性能

MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome mice

MCT1 依赖性能量衰竭和神经炎症是 Wolfram 综合征小鼠视神经退化的原因

A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor development

SOX2基因工程改造的表观遗传沉默因子抑制胶质母细胞瘤的基因表达程序，从而抑制肿瘤发展。

Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications

通过 SNCA 增殖的一组新的同源 iPSC 系衍生的多巴胺能神经元中的天然和种子突触核蛋白聚集和相关细胞功能障碍进行建模

Author Correction: Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity

作者更正：小胶质细胞特异性α-突触核蛋白过度表达会导致吞噬细胞耗竭和氧化毒性，进而引发严重的多巴胺能神经退行性变。

Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity

小胶质细胞特异性 α-突触核蛋白过度表达通过吞噬细胞衰竭和氧化毒性导致严重的多巴胺能神经变性

AAV-PHP.B-Mediated Global-Scale Expression in the Mouse Nervous System Enables GBA1 Gene Therapy for Wide Protection from Synucleinopathy

AAV-PHP.B 介导的小鼠神经系统中的全球性表达使 GBA1 基因疗法能够广泛预防突触核蛋白病