日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Bexicaserin for the treatment of seizures in developmental and epileptic encephalopathies: A phase 1b/2a trial (PACIFIC)

贝西卡塞林治疗发育性和癫痫性脑病引起的癫痫发作：一项 1b/2a 期试验 (PACIFIC)

期刊:Epilepsia
影响因子:6.6
doi:10.1111/epi.18689
Dlugos, Dennis J; Scheffer, Ingrid E; French, Jacqueline A; Vossler, David G; Orevillo, Chad; Polega, Shikha; Kaye, Randall
发育与干细胞
癫痫
神经科学
发表日期：2026
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Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Bexicaserin in Healthy Participants: A First-in-Human Randomized, Double-Blind, Placebo-Controlled Single Ascending Dose Escalation Phase 1 Study

贝西卡司林在健康受试者中的安全性、耐受性、药代动力学、药效学和食物效应：一项首次人体随机、双盲、安慰剂对照单次递增剂量I期研究

期刊:Clinical Pharmacology in Drug Development
影响因子:1.8
doi:10.1002/cpdd.1600
Chan, Rosa; Orevillo, Chad; O'Connell, Gale; McLin, Dewey; Polega, Shikha; Srinivas, Nuggehally R; Kaye, Randall
Human
发表日期：2026
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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double-Blind, Placebo-Controlled Study

在一项随机、双盲、安慰剂对照研究中，评估了健康受试者多次递增剂量和剂量滴定使用贝克西卡林的安全性、耐受性、药代动力学和药效学。

期刊:Clinical Pharmacology in Drug Development
影响因子:1.8
doi:10.1002/cpdd.1602
Williams, Jonathan; Chan, Rosa; Orevillo, Chad; O'Connell, Gale; McLin, Dewey; Polega, Shikha; Srinivas, Nuggehally R; Kaye, Randall
发表日期：2026
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A randomized, seven-day study to assess the efficacy and safety of a glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler using novel Co-Suspension™ Delivery Technology in patients with moderate-to-very severe chronic obstructive pulmonary disease

一项随机、为期七天的研究，旨在评估采用新型 Co-Suspension™ 递送技术的格隆溴铵/富马酸福莫特罗固定剂量复方定量吸入剂在中度至极重度慢性阻塞性肺疾病患者中的疗效和安全性。

期刊:Respiratory Research
影响因子:5
doi:10.1186/s12931-016-0491-8
Reisner, Colin; Fabbri, Leonardo M; Kerwin, Edward M; Fogarty, Charles; Spangenthal, Selwyn; Rabe, Klaus F; Ferguson, Gary T; Martinez, Fernando J; Donohue, James F; Darken, Patrick; St Rose, Earl; Orevillo, Chad; Strom, Shannon; Fischer, Tracy; Golden, Michael; Dwivedi, Sarvajna
慢性阻塞性肺疾病
发表日期：2017
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24-h bronchodilation and inspiratory capacity improvements with glycopyrrolate/formoterol fumarate via co-suspension delivery technology in COPD

在慢性阻塞性肺疾病中，采用共悬浮给药技术给予格隆溴铵/富马酸福莫特罗，可24小时改善支气管扩张和吸气能力。

期刊:Respiratory Research
影响因子:5
doi:10.1186/s12931-017-0636-4
Reisner, Colin; Gottschlich, Gregory; Fakih, Faisal; Koser, Andras; Krainson, James; Delacruz, Luis; Arora, Samir; Feldman, Gregory; Pudi, Krishna; Siddiqui, Shahid; Orevillo, Chad; Maes, Andrea; St Rose, Earl; Martin, Ubaldo
慢性阻塞性肺疾病
发表日期：2017
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Erratum to: A randomized, seven-day study to assess the efficacy and safety of a glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler using novel Co-Suspension™ Delivery Technology in patients with moderate-to-very severe chronic obstructive pulmonary disease

更正：一项随机、为期七天的研究，旨在评估使用新型 Co-Suspension™ 递送技术的格隆溴铵/富马酸福莫特罗固定剂量复方定量吸入器在中度至极重度慢性阻塞性肺疾病患者中的疗效和安全性。

期刊:Respiratory Research
影响因子:5
doi:10.1186/s12931-017-0638-2
Reisner, Colin; Fabbri, Leonardo M; Kerwin, Edward M; Fogarty, Charles; Spangenthal, Selwyn; Rabe, Klaus F; Ferguson, Gary T; Martinez, Fernando J; Donohue, James F; Darken, Patrick; St Rose, Earl; Orevillo, Chad; Strom, Shannon; Fischer, Tracy; Golden, Michael; Dwivedi, Sarvajna
慢性阻塞性肺疾病
发表日期：2017
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Dose-response to inhaled glycopyrrolate delivered with a novel Co-Suspension™ Delivery Technology metered dose inhaler (MDI) in patients with moderate-to-severe COPD

采用新型Co-Suspension™递送技术定量吸入器（MDI）吸入格隆溴铵治疗中重度慢性阻塞性肺疾病患者的剂量反应

期刊:Respiratory Research
影响因子:5
doi:10.1186/s12931-016-0426-4
Fabbri, Leonardo M; Kerwin, Edward M; Spangenthal, Selwyn; Ferguson, Gary T; Rodriguez-Roisin, Roberto; Pearle, James; Sethi, Sanjay; Orevillo, Chad; Darken, Patrick; St Rose, Earl; Fischer, Tracy; Golden, Michael; Dwivedi, Sarvajna; Reisner, Colin
慢性阻塞性肺疾病
发表日期：2016
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Randomized study of the safety, pharmacokinetics, and bronchodilatory efficacy of a proprietary glycopyrronium metered-dose inhaler in study patients with chronic obstructive pulmonary disease

一项随机研究旨在评估一种专有的格隆溴铵定量吸入器在慢性阻塞性肺疾病患者中的安全性、药代动力学和支气管扩张疗效。

期刊:BMC Pulmonary Medicine
影响因子:2.8
doi:10.1186/1471-2466-14-118
Rennard, Stephen; Fogarty, Charles; Reisner, Colin; Fernandez, Carlos; Fischer, Tracy; Golden, Michael; Rose, Earl St; Darken, Patrick; Tardie, Gregory; Orevillo, Chadwick
慢性阻塞性肺疾病
发表日期：2014
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