日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Leveraging multiomic approaches to elucidate mechanisms of heterogeneity in Alzheimer's disease: Neuropsychiatric symptoms, co-pathologies, and sex differences

利用多组学方法阐明阿尔茨海默病异质性机制:神经精神症状、共病及性别差异

Shwab, E Keats; Pathak, Gita A; Harvey, Joshua; Belloy, Michael E; Fischer, Corinne E; Lutz, Michael W; Scholz, Sonja W; Cook, Noah; Reid, Danielle M; Chen, Jingchun; Guan, Dylan X; Oliveira, Fabricio; Sinclair, Lindsey I; Imo, Uzochukwu; Creese, Byron; Chiba-Falek, Ornit

Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseases

神经退行性疾病单细胞转录组图谱的比较分析

Shwab, E Keats; Man, Zhaohui; Gingerich, Daniel C; Gamache, Julia; Garrett, Melanie E; Serrano, Geidy E; Beach, Thomas G; Crawford, Gregory E; Ashley-Koch, Allison E; Chiba-Falek, Ornit

Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease

阿尔茨海默病中小胶质细胞易发生衰老和胆固醇失调

Li, Boyang; Wang, Shaowei; Kerman, Bilal; Hugo, Cristelle; Shwab, E Keats; Shu, Chang; Chiba-Falek, Ornit; Arvanitakis, Zoe; N Yassine, Hussein

Trends and challenges of AAV-delivered gene editing therapeutics for CNS disorders: Implications for neurodegenerative disease

AAV递送基因编辑疗法治疗中枢神经系统疾病的趋势与挑战:对神经退行性疾病的启示

Kantor, Boris; O'Donovan, Bernadette; Chiba-Falek, Ornit

APOE-Targeted Therapeutics for Alzheimer's Disease

针对阿尔茨海默病的APOE靶向疗法

Yassine, Hussein N; Hugo, Cristelle; O'Donovan, Bernadette; Stephens, Isaiah O; Johnson, Lance A; Cole, Gregory; Tcw, Julia; Johansson, Jan; Kisler, Kassandra; Chiba-Falek, Ornit

Residential Socio-Demographic Scoring and Child Growth

居住地社会人口统计评分与儿童成长

Cohen, Ornit; Bilenko, Natalya; Israel, Eytan; Daniel, Sharon

Single cell transcriptomics reveals enrichment of aggregation-prone alpha-synuclein isoforms across synucleinopathies

单细胞转录组学揭示了易聚集α-突触核蛋白亚型在突触核蛋白病中的富集

Shwab, E Keats; Pierson, Webb; Gingerich, Daniel C; Man, Zhaohui; Margalit, Sapir; Yona, Dean; Sivan, Asaf; Gamache, Julia; Serrano, Geidy E; Beach, Thomas G; Ebenstein, Yuval; Beck, Roy; Chiba-Falek, Ornit

Striatal and hippocampal contributions to instrumental learning in the mouse using high-resolution behavioral monitoring and fMRI

利用高分辨率行为监测和功能磁共振成像技术研究纹状体和海马体在小鼠工具性学习中的作用

Bergmann, Eyal; Lichtman, Daniela; Resulaj, Admir; Yona, Guy; Nahman, Ornit; Rinberg, Dmitry; Kahn, Itamar

SNCA -targeted epigenome therapy for Parkinson's disease alleviates pathological and behavioral perturbations in a mouse model.

针对帕金森病的 SNCA 靶向表观基因组疗法可减轻小鼠模型中的病理和行为紊乱

O'Donovan Bernadette, Rittiner Joseph, Upadhya Suraj, Hodgson Dellila, Kantor Boris, Chiba-Falek Ornit

The therapeutic implications of all-in-one AAV-delivered epigenome-editing platform in neurodegenerative disorders

一体化 AAV 表观基因组编辑平台对神经退行性疾病的治疗意义

Boris Kantor, Bernadette O'Donovan #, Joseph Rittiner #, Dellila Hodgson, Nicholas Lindner, Sophia Guerrero, Wendy Dong, Austin Zhang, Ornit Chiba-Falek