日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Repeat-associated non-AUG translation as a common mechanism for the polyGln ataxias

重复序列相关的非AUG翻译是多聚谷氨酰胺共济失调的常见机制

Banez-Coronel, Monica; Zu, Tao; Aldridge, Madeline; Guo, Shu; Ajredini, Ramadan; Morrison, Deborah; Tays, Alexis B; Duvick, Lisa A; Pletnikova, Olga; Yachnis, Anthony T; Troncoso, Juan C; Paulson, Henry L; McLoughlin, Hayley S; Ashizawa, Tetsuo; Subramony, S H; Orr, Harry T; Ranum, Laura P W

Neural basis for mutant ATAXIN-1 induced respiratory dysfunction in mouse models of spinocerebellar ataxia type 1

突变型共济失调1型小鼠模型中ATAXIN-1诱导呼吸功能障碍的神经基础

Soles, Alyssa; Grittner, Jessica; Douglas, Kaia; Yang, Praseuth; Duvick, Lisa; O'Callaghan, Brennon; Barnett, Ryan; Chau, Christine; Cosiquien, Roj; Rainwater, Orion; Serres, Shannah; Dougherty, Brendan; Orr, Harry T; Cvetanovic, Marija

Impaired motor activity in a CRISPR SCA5 L253P knock-in mouse is associated with selective β-III-spectrin subcellular redistribution in the cerebellum

CRISPR SCA5 L253P 敲入小鼠的运动功能障碍与小脑中 β-III-spectrin 的选择性亚细胞重分布有关

Avery, Adam W; O'Callaghan, Brennon L; Thiel, Matthew T; Denha, Sarah A; O'Callaghan, Devon G; Cismas, Emma M; Lamp, Jared; Orr, Harry T; Hays, Thomas S

An expanded polyglutamine in ATAXIN1 results in a loss-of-function that exacerbates severity of Multiple Sclerosis in an EAE mouse model

ATAXIN1 中多聚谷氨酰胺的扩增导致其功能丧失,从而加剧 EAE 小鼠模型中多发性硬化症的严重程度。

Talukdar, Gourango; Duvick, Lisa; Yang, Praseuth; O'Callaghan, Brennon; Fuchs, Gavin J; Cvetanovic, Marija; Orr, Harry T

Striatal pathology in Spinocerebellar Ataxia Type 1 mice: A comparative study with Huntington's disease

脊髓小脑性共济失调1型小鼠纹状体病理:与亨廷顿病的比较研究

Goel, Pragya; Yang, Praseuth; Duvick, Lisa; Rainwater, Orion; Serres, Shannah; O'Callaghan, Brennon; Gomez-Pastor, Rocio; Mehkary, Mustafa; Gall-Duncan, Terence; Langfelder, Peter; Yang, X William; Pearson, Christopher E; Rothwell, Patrick E; Orr, Harry T

Expanded ATXN1 alters transcription and calcium signaling in SCA1 human motor neurons differentiated from induced pluripotent stem cells.

扩增的 ATXN1 会改变由诱导多能干细胞分化而来的 SCA1 人类运动神经元的转录和钙信号传导

Sheeler Carrie, Labrada Emmanuel, Duvick Lisa, Thompson Leslie M, Zhang Ying, Orr Harry T, Cvetanovic Marija

Increased intrinsic membrane excitability is associated with olivary hypertrophy in spinocerebellar ataxia type 1.

脊髓小脑性共济失调 1 型与橄榄核肥大有关,而橄榄核肥大与内在膜兴奋性增加有关

Morrison Logan M, Huang Haoran, Handler Hillary P, Fu Min, Jones Deborah M, Bushart David D, Pappas Samuel S, Orr Harry T, Shakkottai Vikram G

HD and SCA1: Tales from two 30-year journeys since gene discovery

HD 和 SCA1:基因发现以来两段长达 30 年的历程

Thompson, Leslie M; Orr, Harry T

Autistic-like behavior and cerebellar dysfunction in Bmal1 mutant mice ameliorated by mTORC1 inhibition

mTORC1抑制剂可改善Bmal1突变小鼠的自闭症样行为和小脑功能障碍

Liu, Dong; Nanclares, Carmen; Simbriger, Konstanze; Fang, Kun; Lorsung, Ethan; Le, Nam; Amorim, Inês Silva; Chalkiadaki, Kleanthi; Pathak, Salil Saurav; Li, Jin; Gewirtz, Jonathan C; Jin, Victor X; Kofuji, Paulo; Araque, Alfonso; Orr, Harry T; Gkogkas, Christos G; Cao, Ruifeng

Regional sex differences in neurochemical profiles of healthy mice measured by magnetic resonance spectroscopy at 9.4 tesla

利用9.4特斯拉磁共振波谱法测量健康小鼠神经化学特征的区域性别差异

Tkáč, Ivan; Xie, Tiankai; Shah, Nitya; Larson, Sarah; Dubinsky, Janet M; Gomez-Pastor, Rocio; McLoughlin, Hayley S; Orr, Harry T; Eberly, Lynn E; Öz, Gülin