日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

T4 DNA polymerase prevents deleterious on-target DNA damage and enhances precise CRISPR editing

T4 DNA 聚合酶可防止有害的靶向 DNA 损伤并增强精确的 CRISPR 编辑

Qiaoyan Yang, Jonathan S Abebe, Michelle Mai, Gabriella Rudy, Sang Y Kim, Orrin Devinsky, Chengzu Long

Modeling and correction of protein conformational disease in iPSC-derived neurons through personalized base editing

通过个性化碱基编辑对 iPSC 衍生神经元中的蛋白质构象疾病进行建模和校正

Colin T Konishi, Nancy Mulaiese, Tanvi Butola, Qinkun Zhang, Dana Kagan, Qiaoyan Yang, Mariel Pressler, Brooke G Dirvin, Orrin Devinsky, Jayeeta Basu, Chengzu Long

Deoxyhypusine synthase deficiency syndrome zebrafish model: aberrant morphology, epileptiform activity, and reduced arborization of inhibitory interneurons

脱氧尿苷合酶缺乏综合征斑马鱼模型:异常形态、癫痫样活动和抑制性中间神经元树突状化减少

Elham Shojaeinia, Teresa L Mastracci, Remon Soliman, Orrin Devinsky, Camila V Esguerra, Alexander D Crawford

Comparison of the Amyloid Plaque Proteome in Down Syndrome, Early-Onset Alzheimer's Disease and Late-Onset Alzheimer's Disease

唐氏综合症、早发性阿尔茨海默病和晚发性阿尔茨海默病的淀粉样斑块蛋白质组比较

Mitchell Martá-Ariza, Dominique F Leitner, Evgeny Kanshin, Jianina Suazo, Ana Giusti Pedrosa, Manon Thierry, Edward B Lee, Orrin Devinsky, Eleanor Drummond, Juan Fortea, Alberto Lleó, Beatrix Ueberheide, Thomas Wisniewski

Closed-loop brain stimulation augments fear extinction in male rats

闭环脑刺激增强雄性大鼠的恐惧消退

Rodrigo Ordoñez Sierra #, Lizeth Katherine Pedraza #, Lívia Barcsai, Andrea Pejin, Qun Li, Gábor Kozák, Yuichi Takeuchi, Anett J Nagy, Magor L Lőrincz, Orrin Devinsky, György Buzsáki, Antal Berényi

Reinstating olfactory bulb-derived limbic gamma oscillations alleviates depression-like behavioral deficits in rodents

恢复嗅球衍生的边缘伽马振荡可减轻啮齿动物的抑郁样行为缺陷

Qun Li, Yuichi Takeuchi, Jiale Wang, Levente Gellért, Livia Barcsai, Lizeth K Pedraza, Anett J Nagy, Gábor Kozák, Shinya Nakai, Shigeki Kato, Kazuto Kobayashi, Masahiro Ohsawa, Gyöngyi Horváth, Gabriella Kékesi, Magor L Lőrincz, Orrin Devinsky, György Buzsáki, Antal Berényi

Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity

大麻二酚调节兴奋抑制比以对抗海马过度活跃

Evan C Rosenberg, Simon Chamberland, Michael Bazelot, Erica R Nebet, Xiaohan Wang, Sam McKenzie, Swati Jain, Stuart Greenhill, Max Wilson, Nicole Marley, Alejandro Salah, Shanice Bailey, Pabitra Hriday Patra, Rebecca Rose, Nicolas Chenouard, Simón E D Sun, Drew Jones, György Buzsáki, Orrin Devinsky,

POLR1A variants underlie phenotypic heterogeneity in craniofacial, neural, and cardiac anomalies

POLR1A 变异是颅面、神经和心脏异常表型异质性的基础

Kelly Smallwood, Kristin E N Watt, Satoru Ide, Kristina Baltrunaite, Chad Brunswick, Katherine Inskeep, Corrine Capannari, Margaret P Adam, Amber Begtrup, Debora R Bertola, Laurie Demmer, Erin Demo, Orrin Devinsky, Emily R Gallagher, Maria J Guillen Sacoto, Robert Jech, Boris Keren, Jennifer Kussman

Localized proteomic differences in the choroid plexus of Alzheimer's disease and epilepsy patients

阿尔茨海默病和癫痫患者脉络丛局部蛋白质组学差异

Dominique F Leitner, Evgeny Kanshin, Arline Faustin, Manon Thierry, Daniel Friedman, Sasha Devore, Beatrix Ueberheide, Orrin Devinsky, Thomas Wisniewski

Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood

儿童不明原因猝死的海马和皮质蛋白质组学差异

Dominique F Leitner, Christopher William, Arline Faustin, Manor Askenazi, Evgeny Kanshin, Matija Snuderl, Declan McGuone, Thomas Wisniewski, Beatrix Ueberheide, Laura Gould, Orrin Devinsky