日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rabin8 phosphorylated by NDR2, the canine early retinal degeneration gene product, directs rhodopsin Golgi-to-cilia trafficking

Rabin8 被犬早期视网膜变性基因产物 NDR2 磷酸化,指导视紫红质从高尔基体到纤毛的运输

Theresa Fresquez, Beatrice M Tam, Shannon C Eshelman, Orson L Moritz, Michael A Robichaux, Dusanka Deretic

Germline CRISPR/Cas9-Mediated Gene Editing Prevents Vision Loss in a Novel Mouse Model of Aniridia

种系 CRISPR/Cas9 介导的基因编辑可防止新型无虹膜小鼠模型出现视力丧失

Seyedeh Zeinab Mirjalili Mohanna, Jack W Hickmott, Siu Ling Lam, Nina Y Chiu, Tess C Lengyell, Beatrice M Tam, Orson L Moritz, Elizabeth M Simpson

Autophagy in Xenopus laevis rod photoreceptors is independently regulated by phototransduction and misfolded RHOP23H

非洲爪蟾视杆光感受器中的自噬受光转导和错误折叠的 RHOP23H 独立调控

Runxia H Wen, Paloma Stanar, Beatrice Tam, Orson L Moritz

Cell Death Pathways in Mutant Rhodopsin Rat Models Identifies Genotype-Specific Targets Controlling Retinal Degeneration

突变视紫红质大鼠模型中的细胞死亡途径确定了控制视网膜变性的基因型特异性靶点

Ishaq A Viringipurampeer, Cheryl Y Gregory-Evans, Andrew L Metcalfe, Emran Bashar, Orson L Moritz, Kevin Gregory-Evans

An interaction network between the SNARE VAMP7 and Rab GTPases within a ciliary membrane-targeting complex

纤毛膜靶向复合物中 SNARE VAMP7 和 Rab GTPases 之间的相互作用网络

Vasundhara Kandachar, Beatrice M Tam, Orson L Moritz, Dusanka Deretic

Opposing Effects of Valproic Acid Treatment Mediated by Histone Deacetylase Inhibitor Activity in Four Transgenic X. laevis Models of Retinitis Pigmentosa

组蛋白去乙酰化酶抑制剂活性介导的丙戊酸治疗在四种转基因 X. laevis 视网膜色素变性模型中的相反作用

Ruanne Y J Vent-Schmidt, Runxia H Wen, Zusheng Zong, Colette N Chiu, Beatrice M Tam, Christopher G May, Orson L Moritz

NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration

在 P23H 视紫红质视网膜变性模型中,NLRP3 炎症小体激活导致旁观者视锥细胞死亡

Ishaq A Viringipurampeer, Andrew L Metcalfe, Abu E Bashar, Olena Sivak, Anat Yanai, Zeinabsadat Mohammadi, Orson L Moritz, Cheryl Y Gregory-Evans, Kevin Gregory-Evans

Light Induces Ultrastructural Changes in Rod Outer and Inner Segments, Including Autophagy, in a Transgenic Xenopus laevis P23H Rhodopsin Model of Retinitis Pigmentosa

在转基因非洲爪蟾 P23H 视紫红质视网膜色素变性模型中,光诱导视杆细胞外节和内节的超微结构变化,包括自噬

Tami H Bogéa, Runxia H Wen, Orson L Moritz

Kinesin family 17 (osmotic avoidance abnormal-3) is dispensable for photoreceptor morphology and function

驱动蛋白家族 17(渗透回避异常-3)对于光感受器的形态和功能而言并非必不可少

Li Jiang, Beatrice M Tam, Guoxing Ying, Sen Wu, William W Hauswirth, Jeanne M Frederick, Orson L Moritz, Wolfgang Baehr

Photoactivation-induced instability of rhodopsin mutants T4K and T17M in rod outer segments underlies retinal degeneration in X. laevis transgenic models of retinitis pigmentosa

光激活诱导的视杆外节视紫红质突变体 T4K 和 T17M 不稳定性是 X. laevis 转基因视网膜色素变性模型中视网膜变性的基础

Beatrice M Tam, Syed M Noorwez, Shalesh Kaushal, Masahiro Kono, Orson L Moritz