日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Cyclic GMP-AMP synthase deficiency predisposes the liver to alcohol-induced cell death and ER stress

环磷酸鸟苷-AMP合成酶缺乏会使肝脏更容易受到酒精诱导的细胞死亡和内质网应激的影响。

期刊:Hepatology Communications
影响因子:4.6
doi:10.1097/HC9.0000000000000908
Babuta, Mrigya; Datta, Aditi Ashish; de Carvalho Ribeiro, Marcelle; Santos, Bruna de Araújo Cardoso Dos; Morel, Caroline; Copeland, Christopher; Ortega-Ribera, Marti; Mehta, Jeeval; Calenda, Charles; Wang, Yanbo; Remotti, Victoria; Brezani, Viliam; Patel, Arman; Hawryluk, Danielle; Szabo, Gyongyi
细胞生物学
内质网应激
发表日期：2026
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Transcriptome of monocytes from liver, brain and bone marrow reveals organ-specific features in aging and alcohol misuse

肝脏、大脑和骨髓单核细胞的转录组揭示了衰老和酒精滥用中的器官特异性特征

期刊:Jhep Reports
影响因子:9.5
doi:10.1016/j.jhepr.2025.101603
Martí Ortega-Ribera ，Radhika Joshi ，Sergi Guixé-Muntet ，Veronika Brezani ，Prashanth Thevkar Nagesh ，Viliam Brezani ，Arman Patel ，Yuan Zhuang ，Mrigya Babuta ，Jordi Gracia-Sancho ，Gyongyi Szabo
神经科学
发表日期：2025
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Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer's disease associated with inflammasome activation and ASC speck propagation

乙醇摄入会加剧阿尔茨海默病中的淀粉样蛋白病理和神经炎症，这与炎症小体激活和ASC斑点扩散有关。

期刊:Journal of Neuroinflammation
影响因子:9.3
doi:10.1186/s12974-025-03501-8
Veronika Brezani ，Radhika S Joshi ，Marti Ortega-Ribera ，Prashanth Thevkar Nagesh ，Viliam Brezani ，Adam Zivny ，Evelyn A Kurt-Jones ，Douglas T Golenbock ，Gyongyi Szabo
ASC
炎性小体
炎症/感染
炎性小体
神经炎症
阿尔茨海默症
神经科学
炎症
免疫/内分泌
发表日期：2025
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A Novel Multi-organ Male Model of Alcohol-induced Acute-on-chronic Liver Failure Reveals NET-mediated Hepatocellular Death, Which is Prevented by RIPK3 Inhibition

一种新型多器官雄性酒精性急性加慢性肝衰竭模型揭示了NET介导的肝细胞死亡，而RIPK3抑制剂可阻止这种死亡。

期刊:Cellular and Molecular Gastroenterology and Hepatology
影响因子:7.1
doi:10.1016/j.jcmgh.2024.101446
Martí Ortega-Ribera ，Yuan Zhuang ，Mrigya Babuta ，Veronika Brezani ，Radhika S Joshi ，Zsuzsanna Zsengeller ，Prashanth Thevkar Nagesh ，Yanbo Wang ，Roderick Bronson ，Gyongyi Szabo
细胞生物学
RIPK3
肝衰竭
RIP
毒理研究
发表日期：2025
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Gasdermin D deletion prevents liver injury and exacerbates extrahepatic damage in a murine model of alcohol-induced ACLF.

Gasdermin D 缺失可预防酒精性急性肝衰竭小鼠模型中的肝损伤，并加剧肝外损伤

期刊:
影响因子:
doi:10.1136/egastro-2024-100151
Ortega-Ribera Martí, Zhuang Yuan, Brezani Veronika, Joshi Radhika S, Zsengeller Zsuzsanna, Nagesh Prashanth Thevkar, Datta Aditi, Szabo Gyongyi
毒理研究
肝损伤
发表日期：2025
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Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis

中性粒细胞胞外陷阱通过NLRP3感应激活肝星状细胞和单核细胞，从而加速酒精诱导的MASH纤维化。

期刊:Gut
影响因子:25.8
doi:10.1136/gutjnl-2023-331447
Babuta, Mrigya; Morel, Caroline; de Carvalho Ribeiro, Marcelle; Calenda, Charles; Ortega-Ribera, Martí; Thevkar Nagesh, Prashanth; Copeland, Christopher; Zhuang, Yuan; Wang, Yanbo; Cho, Yeonhee; Joshi, Radhika; Brezani, Viliam; Hawryluk, Danielle; Datta, Aditi Ashish; Mehta, Jeeval; Nasser, Imad; Szabo, Gyongyi
中性粒细胞
粒细胞
LRP3
单核细胞
NLRP3
细胞生物学
发表日期：2024
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Bile acid-induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1

胆汁酸诱导的IRF3磷酸化通过调节ZBP1介导胆汁淤积引起的肝肾损伤中的细胞死亡、炎症反应和纤维化。

期刊:Hepatology
影响因子:15.8
doi:10.1097/HEP.0000000000000611
Zhuang, Yuan; Ortega-Ribera, Martí; Thevkar Nagesh, Prashanth; Joshi, Radhika; Huang, Huihui; Wang, Yanbo; Zivny, Adam; Mehta, Jeeval; Parikh, Samir M; Szabo, Gyongyi
IRF3
炎症
炎症/感染
信号转导
ZBP1
肾损伤
磷酸化
细胞生物学
毒理研究
发表日期：2024
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In vivo Bruton's tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis

体内布鲁顿酪氨酸激酶抑制剂通过调节CD84介导的粒细胞生成来减轻酒精相关性肝病

期刊:Science Translational Medicine
影响因子:14.6
doi:10.1126/scitranslmed.adg1915
Nagesh, Prashanth Thevkar; Cho, Yeonhee; Zhuang, Yuan; Babuta, Mrigya; Ortega-Ribera, Marti; Joshi, Radhika; Brezani, Veronika; Patel, Arman; Datta, Aditi Ashish; Brezani, Viliam; Hsieh, Yun-Cheng; Ramos, Adriana; Mehta, Jeeval; Copeland, Christopher; Kanata, Eleni; Jiang, Zhenghui Gordon; Vlachos, Ioannis; Asara, John; Szabo, Gyongyi
T细胞
信号转导
CD8
粒细胞
CD84
细胞生物学
发表日期：2024
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IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease

IRF3调节神经炎症反应和与阿尔茨海默病相关的基因表达

期刊:Journal of Neuroinflammation
影响因子:9.3
doi:10.1186/s12974-024-03203-7
Radhika Joshi ，Veronika Brezani ，Gabrielle M Mey ，Sergi Guixé-Muntet ，Marti Ortega-Ribera ，Yuan Zhuang ，Adam Zivny ，Sebastian Werneburg ，Jordi Gracia-Sancho ，Gyongyi Szabo
阿尔茨海默症
炎症/感染
IRF3
神经炎症
炎症
神经科学
发表日期：2024
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Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression

酒精相关性肝病结局：肝损伤进展的关键机制

期刊:Biomolecules
影响因子:4.8
doi:10.3390/biom14040404
Osna, Natalia A; Tikhanovich, Irina; Ortega-Ribera, Martí; Mueller, Sebastian; Zheng, Chaowen; Mueller, Johannes; Li, Siyuan; Sakane, Sadatsugu; Weber, Raquel Carvalho Gontijo; Kim, Hyun Young; Lee, Wonseok; Ganguly, Souradipta; Kimura, Yusuke; Liu, Xiao; Dhar, Debanjan; Diggle, Karin; Brenner, David A; Kisseleva, Tatiana; Attal, Neha; McKillop, Iain H; Chokshi, Shilpa; Mahato, Ram; Rasineni, Karuna; Szabo, Gyongyi; Kharbanda, Kusum K
肝损伤
毒理研究
发表日期：2024
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