日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combination radiation and αPD-L1 enhance tumor control by stimulating CD8+ PD-1+ TCF-1+ T cells in the tumor-draining lymph node

联合放疗和αPD-L1可通过刺激肿瘤引流淋巴结中的CD8+PD-1+TCF-1+T细胞来增强肿瘤控制。

Shen, Yang; Connolly, Erin; Aiello, Meili; Zhou, Chengjing; Chappa, Prasanthi; Song, Haorui; Tippitak, Patan; Clark, Tarralyn; Cardenas, Maria; Prokhnevska, Nataliya; Mariniello, Annapaola; De Bruyker, Isabelle; Pagadala, Meghana S; Dhere, Vishal R; Rafiq, Sarwish; Kesarwala, Aparna H; Orthwein, Alexandre; Thomas, Susan N; Zhang, Shirley L; Khan, Mohammad K; Dixon, J Brandon; Lesinski, Gregory B; Lowe, Michael C; Kissick, Haydn; Yu, David S; Paulos, Chrystal M; Schmitt, Nicole C; Buchwald, Zachary S

The E3 ubiquitin ligase Herc1 modulates the response to nucleoside analogs in acute myeloid leukemia.

E3泛素连接酶Herc1调节急性髓系白血病对核苷类似物的反应

Jankovic Maja, Poon William W L, Gonzales-Losada Cristobal, Vazquez Gabriela Galicia, Sharif-Askari Bahram, Ding Yi, Craplet-Desombre Constance, Ilie Alexandru, Shi Jiantao, Wang Yongjie, Jayavelu Ashok Kumar, Orthwein Alexandre, Mercier François Émile

An E3 ubiquitin ligase localization screen uncovers DTX2 as a novel ADP-ribosylation-dependent regulator of DNA double-strand break repair

E3 泛素连接酶定位筛选发现 DTX2 是一种新型的 ADP 核糖基化依赖性 DNA 双链断裂修复调节剂

Billel Djerir, Isabelle Marois, Jean-Christophe Dubois, Steven Findlay, Théo Morin, Issam Senoussi, Laurent Cappadocia, Alexandre Orthwein, Alexandre Maréchal

Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node

放射线和抗PD-L1疗法通过刺激肿瘤引流淋巴结中的干细胞样T细胞群发挥协同作用。

Shen, Yang; Connolly, Erin; Aiello, Meili; Zhou, Chengjing; Chappa, Prasanthi; Song, Haorui; Tippitak, Patan; Clark, Tarralyn; Cardenas, Maria; Prokhnevska, Nataliya; Mariniello, Annapaola; Pagadala, Meghana S; Dhere, Vishal R; Rafiq, Sarwish; Kesarwala, Aparna H; Orthwein, Alexandre; Thomas, Susan N; Khan, Mohammad K; Brandon Dixon, J; Lesinski, Gregory B; Lowe, Michael C; Kissick, Haydn; Yu, David S; Paulos, Chrystal M; Schmitt, Nicole C; Buchwald, Zachary S

B cell-specific knockout of AID protects against atherosclerosis

B细胞特异性敲除AID可预防动脉粥样硬化

Ebrahimian, Talin; Dierick, France; Ta, Vincent; Kotsiopriftis, Maria; O'Connor Miranda, Jonathan; Mann, Koren K; Orthwein, Alexandre; Lehoux, Stephanie

Systematic proximal mapping of the classical RAD51 paralogs unravel functionally and clinically relevant interactors for genome stability

对经典 RAD51 旁系同源基因进行系统性的近端定位,揭示了与基因组稳定性相关的、具有功能和临床意义的相互作用因子。

Simo Cheyou, Estelle; Boni, Jacopo; Boulais, Jonathan; Pinedo-Carpio, Edgar; Malina, Abba; Sherill-Rofe, Dana; Luo, Vincent M; Goncalves, Christophe; Bagci, Halil; Maters, Alexandra; Cuella-Martin, Raquel; Tabach, Yuval; Del Rincon, Sonia; Côté, Jean-Francois; Rivera, Barbara; Orthwein, Alexandre

Multi-omics data integration analysis identifies the spliceosome as a key regulator of DNA double-strand break repair

多组学数据整合分析表明,剪接体是DNA双链断裂修复的关键调控因子。

Sherill-Rofe, Dana; Raban, Oded; Findlay, Steven; Rahat, Dolev; Unterman, Irene; Samiei, Arash; Yasmeen, Amber; Kaiser, Zafir; Kuasne, Hellen; Park, Morag; Foulkes, William D; Bloch, Idit; Zick, Aviad; Gotlieb, Walter H; Tabach, Yuval; Orthwein, Alexandre

Mapping global and local coevolution across 600 species to identify novel homologous recombination repair genes

绘制600个物种的全球和局部协同进化图谱,以识别新的同源重组修复基因

Sherill-Rofe, Dana; Rahat, Dolev; Findlay, Steven; Mellul, Anna; Guberman, Irene; Braun, Maya; Bloch, Idit; Lalezari, Alon; Samiei, Arash; Sadreyev, Ruslan; Goldberg, Michal; Orthwein, Alexandre; Zick, Aviad; Tabach, Yuval

Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1

激活诱导脱氨酶的最佳功能水平特异性地需要 Hsp40 DnaJa1。

Orthwein, Alexandre; Zahn, Astrid; Methot, Stephen P; Godin, David; Conticello, Silvestro G; Terada, Kazutoyo; Di Noia, Javier M