日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A high-throughput, quantitative platform using 2D dissociated human cerebral organoids to model neuroinflammation in Alzheimer's disease

利用二维分离的人类脑类器官构建高通量、定量平台,模拟阿尔茨海默病中的神经炎症

Olson, Meagan N; Barton, Nathaniel J; Feng, Luyao; Chigas, Samantha M; Tran, Khanh; Orszulak, Adrian R; Johnson, Jafira M; Dawes, Pepper; Shrestha, Chandani; Umaiyalan, Vishali R; Huang, Yen-Hsiang; Sundstrom, Jonathan; Murray, Liam F; Wang, Qi; Oh, Hyung Suk; Orzalli, Megan H; Knipe, David M; Readhead, Benjamin; Chan, Yingleong; Lim, Elaine T

Lineage memory shapes viral resistance barriers in human skin

谱系记忆塑造了人类皮肤中的病毒抵抗屏障

Van Eyndhoven, Laura C; Kinsler, Grant; Zhang, Jingchao; O'Farrell, Aoife; Abderrahim, Rim; Srivastav, Apurv; Triandafillou, Catherine G; Greco, Todd M; Zaret, Kenneth S; Cristea, Ileana M; Orzalli, Megan H; Drayman, Nir; Singh, Abhyudai; Raj, Arjun

A viral E3 ubiquitin ligase produced by herpes simplex virus 1 inhibits the NLRP1 inflammasome

单纯疱疹病毒1型产生的一种病毒E3泛素连接酶抑制NLRP1炎症小体。

Pooja Parameswaran ,Laurellee Payne ,Jennifer Powers ,Mehdi Rashighi ,Megan H Orzalli

Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity

甲氨蝶呤通过抑制肽聚糖转运蛋白SLC46A2的活性来抑制银屑病皮肤炎症。

Ravi Bharadwaj ,Christina F Lusi ,Siavash Mashayekh ,Abhinit Nagar ,Malireddi Subbarao ,Griffin I Kane ,Kimberly A Wodzanowski ,Ashley R Brown ,Kendi Okuda ,Amanda Monahan ,Donggi Paik ,Anubhab Nandy ,Madison V Anonick ,William E Goldman ,Thirumala-Devi Kanneganti ,Megan H Orzalli ,Catherine Leimkuhler Grimes ,Prabhani U Atukorale ,Neal Silverman

Herpes simplex virus infected cell protein 8 is required for viral inhibition of the cGAS pathway

单纯疱疹病毒感染细胞蛋白 8 是病毒抑制 cGAS 通路所必需的

Nicole Broekema, Max E Mertens, Magdalena Angelova, Megan H Orzalli, Hyung S Oh, David M Knipe

Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces

病毒和细菌毒素导致顶端内体耗竭,为粘膜表面提供细胞自主的宿主防御

Keiko Maeda, Nicholas C Zachos, Megan H Orzalli, Stefanie S Schmieder, Denis Chang, Katlynn Bugda Gwilt, Michele Doucet, Nicholas W Baetz, Sun Lee, Sue E Crawford, Mary K Estes, Jonathan C Kagan, Jerrold R Turner, Wayne I Lencer

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells

病毒介导的抗凋亡Bcl-2家族成员失活促进屏障上皮细胞中Gasdermin-E依赖性细胞焦亡

Megan H Orzalli ,Aleksandra Prochera ,Laurellee Payne ,Avi Smith ,Jonathan A Garlick ,Jonathan C Kagan

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

STING C 端尾部的模块化结构使其能够适应干扰素和 NF-κB 信号传导。

Carina C de Oliveira Mann ,Megan H Orzalli ,David S King ,Jonathan C Kagan ,Amy S Y Lee ,Philip J Kranzusch

An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication

IL-1信号通路中的抗病毒分支限制免疫逃逸病毒的复制

Megan H Orzalli ,Avi Smith ,Kellie A Jurado ,Akiko Iwasaki ,Jonathan A Garlick ,Jonathan C Kagan

Mechanisms of Host IFI16, PML, and Daxx Protein Restriction of Herpes Simplex Virus 1 Replication

宿主 IFI16、PML 和 Daxx 蛋白限制单纯疱疹病毒 1 型复制的机制

Philipp E Merkl, Megan H Orzalli, David M Knipe