日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities.

抑制早老素 1 家族性阿尔茨海默病突变体的突变调节 α-分泌酶活性

Futai Eugene, Osawa Satoko, Cai Tetsuo, Fujisawa Tomoya, Ishiura Shoichi, Tomita Taisuke

Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation.

较长的 Aβ 与早老素 1 的跨膜结构域 1 结合,影响 Aβ42 的生成

Ohki Yu, Shimada Naoaki, Tominaga Aya, Osawa Satoko, Higo Takuya, Yokoshima Satoshi, Fukuyama Tohru, Tomita Taisuke, Iwatsubo Takeshi

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons

FTY720/芬戈莫德是一种鞘氨醇类似物,可减少神经元中β-淀粉样蛋白的产生。

Takasugi, Nobumasa; Sasaki, Tomoki; Ebinuma, Ihori; Osawa, Satoko; Isshiki, Hayato; Takeo, Koji; Tomita, Taisuke; Iwatsubo, Takeshi

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1.

苯基哌啶型 γ-分泌酶调节剂靶向早老素 1 的跨膜结构域 1

Ohki Yu, Higo Takuya, Uemura Kengo, Shimada Naoaki, Osawa Satoko, Berezovska Oksana, Yokoshima Satoshi, Fukuyama Tohru, Tomita Taisuke, Iwatsubo Takeshi

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

针对尼卡斯特林的单链可变片段可抑制γ-分泌酶活性

Hayashi Ikuo, Takatori Sho, Urano Yasuomi, Iwanari Hiroko, Isoo Noriko, Osawa Satoko, Fukuda Maiko A, Kodama Tatsuhiko, Hamakubo Takao, Li Tong, Wong Philip C, Tomita Taisuke, Iwatsubo Takeshi