文献库，生知库 | 链接生命科学的每一步

日期影响因子

High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase.

高通量筛选发现了一种新型的 Hsp70 小分子调节剂，该调节剂可选择性地增强错误折叠的神经元 NO 合酶的泛素化和降解

期刊:Molecular Pharmacology

doi:10.1016/j.molpha.2024.100008

Garcia Anthony M, Davis Amanda K, Martinez-Ramos Cristian, Morishima Yoshihiro, Lau Miranda, Xu Emily, Sunil Arya, Zhang Haoming, Alt Andrew, Lieberman Andrew P, Osawa Yoichi

发表日期：2025

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A General Method to Screen Nanobodies for Cytochrome P450 Enzymes from a Yeast Surface Display Library

从酵母表面展示文库中筛选细胞色素P450酶纳米抗体的通用方法

期刊:Biomedicines

影响因子:3.9

doi:10.3390/biomedicines12081863

Sun, Yudong; Martinez-Ramos, Cristian; Chen, Eugene; Osawa, Yoichi; Zhang, Haoming

细胞生物学

发表日期：2024

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The Versatile Biocatalyst of Cytochrome P450 CYP102A1: Structure, Function, and Engineering

细胞色素P450 CYP102A1的多功能生物催化剂：结构、功能和工程改造

期刊:Molecules

影响因子:4.6

doi:10.3390/molecules28145353

Sun, Yudong; Huang, Xiaoqiang; Osawa, Yoichi; Chen, Yuqing Eugene; Zhang, Haoming

细胞生物学

发表日期：2023

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Computational redesign of cytochrome P450 CYP102A1 for highly stereoselective omeprazole hydroxylation by UniDesign

UniDesign 利用计算方法重新设计细胞色素 P450 CYP102A1，以实现高立体选择性奥美拉唑羟基化。

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2023.105050

Huang, Xiaoqiang; Sun, Yudong; Osawa, Yoichi; Chen, Y Eugene; Zhang, Haoming

细胞生物学

发表日期：2023

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Amphipol-facilitated elucidation of the functional tetrameric complex of full-length cytochrome P450 CYP2B4 and NADPH-cytochrome P450 oxidoreductase

利用两亲性碱促进全长细胞色素P450 CYP2B4和NADPH-细胞色素P450氧化还原酶的功能性四聚体复合物的解析

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2021.100645

Cheng, Shen; Bo, Zhiyuan; Hollenberg, Paul; Osawa, Yoichi; Zhang, Haoming

细胞生物学

发表日期：2021

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Mapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry

利用交联和质谱法绘制同源二聚体CYP102A1中蛋白质-蛋白质相互作用图谱

期刊:Biophysical Chemistry

影响因子:2.2

doi:10.1016/j.bpc.2021.106590

Felker, Dana; Zhang, Haoming; Bo, Zhiyuan; Lau, Miranda; Morishima, Yoshihiro; Schnell, Santiago; Osawa, Yoichi

发表日期：2021

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Bronchodilator Reversibility Occurring during the Acute Phase of Paragonimiasis westermani Infection

支气管扩张剂在卫氏并殖吸虫感染急性期的可逆性

期刊:Internal Medicine

影响因子:1.1

doi:10.2169/internalmedicine.0401-17

Harada, Tomoya; Kawasaki, Yuji; Tsukada, Akira; Osawa, Yoichi; Takami, Hiroki; Yamaguchi, Kosuke; Kurai, Jun; Yamasaki, Akira; Shimizu, Eiji

发表日期：2019

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The full-length cytochrome P450 enzyme CYP102A1 dimerizes at its reductase domains and has flexible heme domains for efficient catalysis

全长细胞色素P450酶CYP102A1在其还原酶结构域形成二聚体，并具有柔性血红素结构域以实现高效催化。

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1074/jbc.RA117.000600

Zhang, Haoming; Yokom, Adam L; Cheng, Shen; Su, Min; Hollenberg, Paul F; Southworth, Daniel R; Osawa, Yoichi

细胞生物学

发表日期：2018

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Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery

Hsp90α和Hsp90β在多蛋白Hsp90/Hsp70依赖性分子伴侣机制激活糖皮质激素受体中的分子伴侣活性和二聚化特性

期刊:Molecular Pharmacology

doi:10.1124/mol.118.112516

Morishima, Yoshihiro; Mehta, Ranjit K; Yoshimura, Miyako; Lau, Miranda; Southworth, Daniel R; Lawrence, Theodore S; Pratt, William B; Nyati, Mukesh K; Osawa, Yoichi

免疫/内分泌

发表日期：2018

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Significant Improvement of Antithrombotic Responses to Clopidogrel by Use of a Novel Conjugate as Revealed in an Arterial Model of Thrombosis

在动脉血栓模型中，新型偶联物显著提高了氯吡格雷的抗血栓反应。

期刊:Journal of Pharmacology and Experimental Therapeutics

影响因子:3.8

doi:10.1124/jpet.116.236034

Zhang, Haoming; Lauver, D Adam; Wang, Hui; Sun, Duxin; Hollenberg, Paul F; Chen, Y Eugene; Osawa, Yoichi; Eitzman, Daniel T

发表日期：2016

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