日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ

抗麻风药物氯法齐明通过激活PPARγ降低polyQ毒性。

Xuexin Li ,Ivó Hernandez ,Seda Koyuncu ,Balázs Kis ,Maria Häggblad ,Louise Lidemalm ,Anna A Abbas ,Sramkó Bendegúz ,Anikó Göblös ,Lars Brautigam ,Jose J Lucas ,Jordi Carreras-Puigvert ,Daniela Hühn ,Karolina Pircs ,David Vilchez ,Oscar Fernandez-Capetillo

Cyclophilin D plays a critical role in the survival of senescent cells

环孢亲和素D在衰老细胞的存活中起着关键作用。

Margherita Protasoni ,Vanessa López-Polo ,Camille Stephan-Otto Attolini ,Julian Brandariz ,Nicolas Herranz ,Joaquin Mateo ,Sergio Ruiz ,Oscar Fernandez-Capetillo ,Marta Kovatcheva ,Manuel Serrano

Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET

由于双硫仑代谢物 CuET 引起的翻译停滞、p53 聚集和核糖体生物合成应激,导致可操作的癌症脆弱性

Dimitris C Kanellis, Asimina Zisi, Zdenek Skrott, Bennie Lemmens, Jaime A Espinoza, Martin Kosar, Andrea Björkman, Xuexin Li, Stefanos Arampatzis, Jirina Bartkova, Miguel Andújar-Sánchez, Oscar Fernandez-Capetillo, Martin Mistrik, Mikael S Lindström, Jiri Bartek

A chemical screen underscores the essential role of STAT1-dependent IFNγ signaling to regulate HLA-I expression in cancer cells

化学筛选强调了 STAT1 依赖性 IFNγ 信号在调节癌细胞中的 HLA-I 表达中的重要作用

Myriam Barz #, Bartlomiej Porebski #, Pranauti Panshikar, Maria Häggbladd, Daniela Hühn, Oscar Fernandez-Capetillo

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo

双特异性单体纳米抗体诱导刺突三聚体二聚体并在体内中和 SARS-CoV-2

Leo Hanke #, Hrishikesh Das #, Daniel J Sheward, Laura Perez Vidakovics, Egon Urgard, Ainhoa Moliner-Morro, Changil Kim, Vivien Karl, Alec Pankow, Natalie L Smith, Bartlomiej Porebski, Oscar Fernandez-Capetillo, Erdinc Sezgin, Gabriel K Pedersen, Jonathan M Coquet, B Martin Hällberg, Ben Murrell #, 

Activation of the integrated stress response is a vulnerability for multidrug-resistant FBXW7-deficient cells

整合应激反应的激活是多重耐药性FBXW7缺陷细胞的一个脆弱点。

Laura Sanchez-Burgos ,Belén Navarro-González ,Santiago García-Martín ,Oleksandra Sirozh ,Jorge Mota-Pino ,Elena Fueyo-Marcos ,Héctor Tejero ,Marta Elena Antón ,Matilde Murga ,Fátima Al-Shahrour ,Oscar Fernandez-Capetillo

Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells

长期雌激素缺乏会引发乳腺癌细胞出现广泛的免疫抑制表型。

Daniela Hühn ,Pablo Martí-Rodrigo ,Silvana Mouron ,Catherine Hansel ,Kirsten Tschapalda ,Bartlomiej Porebski ,Maria Häggblad ,Louise Lidemalm ,Miguel Quintela-Fandino ,Jordi Carreras-Puigvert ,Oscar Fernandez-Capetillo

New regulators of the tetracycline-inducible gene expression system identified by chemical and genetic screens

通过化学和遗传筛选鉴定出四环素诱导基因表达系统的新调控因子

Valeria Colicchia ,Maria Häggblad ,Oleksandra Sirozh ,Bartlomiej Porebski ,Mirela Balan ,Xuexin Li ,Louise Lidemalm ,Jordi Carreras-Puigvert, Daniela Hühn ,Oscar Fernandez-Capetillo

Widespread displacement of DNA- and RNA-binding factors underlies toxicity of arginine-rich cell-penetrating peptides

富含精氨酸的细胞穿透肽的毒性源于DNA和RNA结合因子的广泛置换。

Vanesa Lafarga ,Oleksandra Sirozh ,Irene Díaz-López ,Antonio Galarreta ,Misaru Hisaoka ,Eduardo Zarzuela ,Jasminka Boskovic ,Bogdan Jovanovic ,Rafael Fernandez-Leiro ,Jaime Muñoz ,Georg Stoecklin ,Iván Ventoso ,Oscar Fernandez-Capetillo

USP7 limits CDK1 activity throughout the cell cycle

USP7 限制整个细胞周期中 CDK1 的活性

Antonio Galarreta, Pablo Valledor, Patricia Ubieto-Capella, Vanesa Lafarga, Eduardo Zarzuela, Javier Muñoz, Marcos Malumbres, Emilio Lecona, Oscar Fernandez-Capetillo