日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A "Function-First" Approach to Identify Regulatory T cell-Targeting Antibodies for Immunotherapy

采用“功能优先”方法鉴定用于免疫治疗的靶向调节性T细胞的抗体

Kirstie L S Cleary # ,Monika Semmrich # ,Linda Martensson ,Ulla-Carin Tornberg ,David Ermert ,Martin C Taylor ,Robert J Oldham ,Osman Dadas ,Josephine F Buckingham ,Jinny Kim ,H T Claude Chan ,Angelica Palm ,Ann-Helen Fischer ,Mimoza Boden ,Jenny Mattsson ,Petra Holmkvist ,Sean H Lim ,Stephen A Beers ,Bjorn Frendeus ,Ingrid Teige ,Mark S Cragg

Fcγ receptor binding is required for maximal immunostimulation by CD70-Fc

Fcγ 受体结合是 CD70-Fc 实现最大免疫刺激的必要条件

Osman Dadas, Joel D Allen, Sarah L Buchan, Jinny Kim, H T Claude Chan, C Ian Mockridge, Patrick J Duriez, Anne Rogel, Max Crispin, Aymen Al-Shamkhani

Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering

激动剂 CD27 抗体效力由通过 Fc 工程增强的表位依赖性受体聚集决定

Franziska Heckel, Anna H Turaj, Hayden Fisher, H T Claude Chan, Michael J E Marshall, Osman Dadas, Christine A Penfold, Tatyana Inzhelevskaya, C Ian Mockridge, Diego Alvarado, Ivo Tews, Tibor Keler, Stephen A Beers, Mark S Cragg, Sean H Lim

Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies

表位特异性和同种型之间的复杂相互作用决定了抗人 CD40 抗体的生物活性

Xiaojie Yu, H T Claude Chan, Christian M Orr, Osman Dadas, Steven G Booth, Lekh N Dahal, Christine A Penfold, Lyn O'Brien, C Ian Mockridge, Ruth R French, Patrick Duriez, Leon R Douglas, Arwen R Pearson, Mark S Cragg, Ivo Tews, Martin J Glennie, Ann L White