日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Herpes Simplex Virus Latency-Associated Transcript Gene Is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8+ T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits

单纯疱疹病毒潜伏相关转录基因与潜伏感染的HLA转基因兔三叉神经节内保留的更广泛的病毒特异性耗竭CD8+ T细胞库相关

Srivastava, Ruchi; Dervillez, Xavier; Khan, Arif A; Chentoufi, Aziz A; Chilukuri, Sravya; Shukr, Nora; Fazli, Yasmin; Ong, Nicolas N; Afifi, Rasha E; Osorio, Nelson; Geertsema, Roger; Nesburn, Anthony B; Wechsler, Steven L; BenMohamed, Lbachir

Confocal Microscopic Analysis of a Rabbit Eye Model of High-Incidence Recurrent Herpes Stromal Keratitis

利用共聚焦显微镜分析兔眼高发复发性疱疹性基质角膜炎模型

Jester, James V; Morishige, Naoyuki; BenMohamed, Lbachir; Brown, Donald J; Osorio, Nelson; Hsiang, Chinhui; Perng, Guey Chuen; Jones, Clinton; Wechsler, Steven L

Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus

压力过大的、潜伏感染单纯疱疹病毒的兔子,其泪液中大量病毒的激活是复发性疱疹性基质角膜炎的前兆。

Perng, Guey-Chuen; Osorio, Nelson; Jiang, Xianzhi; Geertsema, Roger; Hsiang, Chinhui; Brown, Don; BenMohamed, Lbachir; Wechsler, Steven L

Prior Corneal Scarification and Injection of Immune Serum are Not Required Before Ocular HSV-1 Infection for UV-B-Induced Virus Reactivation and Recurrent Herpetic Corneal Disease in Latently Infected Mice

对于潜伏感染小鼠,UV-B诱导的病毒再激活和复发性疱疹性角膜疾病无需事先进行角膜划痕和注射免疫血清即可进行眼部HSV-1感染。

BenMohamed, Lbachir; Osorio, Nelson; Khan, Arif A; Srivastava, Ruchi; Huang, Lei; Krochmal, John J; Garcia, Jairo M; Simpson, Jennifer L; Wechsler, Steven L

Therapeutic immunization with a mixture of herpes simplex virus 1 glycoprotein D-derived “asymptomatic” human CD8+ T-cell epitopes decreases spontaneous ocular shedding in latently infected HLA transgenic rabbits: association with low frequency of local PD-1+ TIM-3+ CD8+ exhausted T cells

用单纯疱疹病毒1型糖蛋白D衍生的“无症状”人CD8+ T细胞表位混合物进行治疗性免疫,可降低潜伏感染HLA转基因兔的自发性眼部脱落:与局部PD-1+ TIM-3+ CD8+耗竭T细胞频率低相关

Khan, Arif A; Srivastava, Ruchi; Chentoufi, Aziz A; Geertsema, Roger; Thai, Nhi Thi Uyen; Dasgupta, Gargi; Osorio, Nelson; Kalantari, Mina; Nesburn, Anthony B; Wechsler, Steven L; BenMohamed, Lbachir

Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation

利用体内小鼠 UV-B 诱导再激活模型,降低单纯疱疹病毒 1 型 (HSV-1) 潜伏相关转录物 (LAT) 突变体的再激活率

BenMohamed, Lbachir; Osorio, Nelson; Srivastava, Ruchi; Khan, Arif A; Simpson, Jennifer L; Wechsler, Steven L

Role of litter turnover in soil quality in tropical degraded lands of Colombia

凋落物周转对哥伦比亚热带退化土地土壤质量的影响

León, Juan D; Osorio, Nelson W

The herpes simplex virus type 1 latency-associated transcript can protect neuron-derived C1300 and Neuro2A cells from granzyme B-induced apoptosis and CD8 T-cell killing.

单纯疱疹病毒 1 型潜伏相关转录本可以保护神经元衍生的 C1300 和 Neuro2A 细胞免受颗粒酶 B 诱导的细胞凋亡和 CD8 T 细胞杀伤

Jiang Xianzhi, Chentoufi Aziz Alami, Hsiang Chinhui, Carpenter Dale, Osorio Nelson, BenMohamed Lbachir, Fraser Nigel W, Jones Clinton, Wechsler Steven L

Introducing point mutations into the ATGs of the putative open reading frames of the HSV-1 gene encoding the latency associated transcript (LAT) reduces its anti-apoptosis activity

在编码潜伏期相关转录本 (LAT) 的 HSV-1 基因的假定开放阅读框的 ATG 中引入点突变会降低其抗凋亡活性。

Carpenter, Dale; Henderson, Gail; Hsiang, Chinhui; Osorio, Nelson; BenMohamed, Lbachir; Jones, Clinton; Wechsler, Steven L

Cellular FLIP can substitute for the herpes simplex virus type 1 latency-associated transcript gene to support a wild-type virus reactivation phenotype in mice

细胞FLIP可以替代单纯疱疹病毒1型潜伏相关转录基因,从而在小鼠体内支持野生型病毒的再激活表型。

Jin, Ling; Carpenter, Dale; Moerdyk-Schauwecker, Megan; Vanarsdall, Adam L; Osorio, Nelson; Hsiang, Chinhui; Jones, Clinton; Wechsler, Steven L