日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Evolving patterns of antimalarial drug resistance markers in symptomatic infections in Kenya, 2013-2022

2013-2022年肯尼亚有症状感染者抗疟药物耐药性标志物演变模式

Magudha, John; Ndwiga, Leonard; Akinyi, Mercy Y; Wamae, Kevin; Osoti, Victor; Kandie, Regina; Kiplagat, Rosebella; Keitany, Kibor; Bargul, Joel L; Akala, Hoseah M; Ochola-Oyier, L Isabella

Serial cross-sectional school surveys identifies C469Y, P553L, R561H and A675V kelch 13 mutations associated with artemisinin resistance in Western Kenya

肯尼亚西部学校的系列横断面调查发现,与青蒿素耐药性相关的 Kelch 13 突变包括 C469Y、P553L、R561H 和 A675V。

Osoti, Victor; Wamae, Kevin; Musau, Moses M; Magudha, John B; Ndwiga, Leonard; Gichuki, Paul M; Okoyo, Collins; Rosebella, Kiplagat; Mahugu, Sammy; Aricha, Stephen; Kandie, Regina; Keitany, Kibor; Kepha, Stella; Mwandawiro, Charles; Bejon, Philip; Snow, Robert W; Ochola-Oyier, L Isabella

Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya

在肯尼亚无症状小学生中检测到低频青蒿素耐药突变(C469Y、P553L 和 A675V)以及固定抗叶酸耐药突变

Osoti, Victor; Wamae, Kevin; Ndwiga, Leonard; Gichuki, Paul M; Okoyo, Collins; Kepha, Stella; Keitany, Kibor; Kandie, Regina; Aricha, Stephen; Kiplagat, Rosebella; Mwandawiro, Charles; Bejon, Philip; Snow, Robert W; Ochola-Oyier, Lynette Isabella

A retrospective analysis of P. falciparum drug resistance markers detects an early (2016/17) high prevalence of the k13 C469Y mutation in asymptomatic infections in Northern Uganda

对恶性疟原虫耐药性标记的回顾性分析发现,在乌干达北部无症状感染者中,k13 C469Y突变在早期(2016/17年)流行率很高。

Ogwang, Rodney; Osoti, Victor; Wamae, Kevin; Ndwiga, Leonard; Muteru, Kelvin; Ningwa, Albert; Tuju, James; Kinyanjui, Sam; Osier, Faith; Marsh, Kevin; Bejon, Philip; Idro, Richard; Ochola-Oyier, Lynette Isabella

ONT sequencing identifies a high prevalence of crt sensitive, triple mutant dhfr and single mutant dhps parasites within an ANC population in Nigeria

ONT测序发现,尼日利亚某孕妇群体中存在高比例的CRT敏感型、三重突变型DHFR和单突变型DHPS寄生虫。

Adegbola, Adebanjo Jonathan; Ndwiga, Leonard; Wamae, Kevin; Osoti, Victor; Bolaji, Oluseye Oladotun; Bejon, Philip; Ochola-Oyier, Lynette Isabella

Validation of saline, PBS and a locally produced VTM at varying storage conditions to detect the SARS-CoV-2 virus by qRT-PCR

在不同储存条件下,通过 qRT-PCR 验证生理盐水、PBS 和本地生产的病毒转运培养基 (VTM) 检测 SARS-CoV-2 病毒的能力。

Ngetsa, Caroline; Osoti, Victor; Okanda, Dorcas; Marura, Faith; Shah, Krupali; Karanja, Henry; Mugo, Daisy; Gitonga, John; Mutunga, Martin; Lewa, Clement; Orindi, Benedict; Bejon, Philip; Ochola-Oyier, Lynette Isabella

Low frequency of Plasmodium falciparum hrp2/3 deletions from symptomatic infections at a primary healthcare facility in Kilifi, Kenya

肯尼亚基利菲一家基层医疗机构中,有症状感染者中恶性疟原虫hrp2/3基因缺失的发生率较低

Okanda, Dorcas; Ndwiga, Leonard; Osoti, Victor; Achieng, Nicole; Wambua, Juliana; Ngetsa, Caroline; Lubell-Doughtie, Peter; Shankar, Anuraj; Bejon, Philip; Ochola-Oyier, Lynette Isabella

Targeted Amplicon Deep Sequencing for Monitoring Antimalarial Resistance Markers in Western Kenya

利用靶向扩增子深度测序技术监测肯尼亚西部抗疟疾耐药性标记

Osoti, Victor; Akinyi, Mercy; Wamae, Kevin; Kimenyi, Kelvin M; de Laurent, Zaydah; Ndwiga, Leonard; Gichuki, Paul; Okoyo, Collins; Kepha, Stella; Mwandawiro, Charles; Kandie, Regina; Bejon, Philip; Snow, Robert W; Ochola-Oyier, Lynette Isabella

Maintenance of high temporal Plasmodium falciparum genetic diversity and complexity of infection in asymptomatic and symptomatic infections in Kilifi, Kenya from 2007 to 2018

2007年至2018年肯尼亚基利菲地区无症状和有症状感染者中恶性疟原虫遗传多样性和感染复杂性的维持

Kimenyi, Kelvin M; Wamae, Kevin; Ngoi, Joyce M; de Laurent, Zaydah R; Ndwiga, Leonard; Osoti, Victor; Obiero, George; Abdi, Abdirahman I; Bejon, Philip; Ochola-Oyier, Lynette Isabella

Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial.

在临床药物试验中,通过对 ama1 和 mdr1 进行靶向扩增子深度测序,追踪整个治疗过程中宿主内恶性疟原虫的多样性。

Wamae Kevin, Ndwiga Leonard, Kharabora Oksana, Kimenyi Kelvin, Osoti Victor, de Laurent Zaydah, Wambua Juliana, Musyoki Jennifer, Ngetsa Caroline, Kalume Peter, Mwambingu Gabriel, Hamaluba Mainga, van der Pluijm Rob, Dondorp Arjen M, Bailey Jeffrey, Juliano Jonathan, Bejon Philip, Ochola-Oyier Lynette