日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Highly specific intracellular ubiquitination of a small molecule.

小分子的高度特异性细胞内泛素化。

Li Weicheng, Garcia-Rivera Enrique M, Mitchell Dylan C, Chick Joel M, Maetani Micah, Bhadoria Rohit, Knapp John M, Misu Ryosuke, Matthews Geoffrey M, Shirasaki Ryosuke, de Matos Simoes Ricardo, Viswanathan Vasanthi, Pulice John L, Rees Matthew G, Roth Jennifer A, Gygi Steven P, Mitsiades Constantine S, Kadoch Cigall, Schreiber Stuart L, Ostrem Jonathan M L

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.

K-Ras(G12C)抑制剂通过变构作用控制GTP亲和力和效应物相互作用

Ostrem Jonathan M, Peters Ulf, Sos Martin L, Wells James A, Shokat Kevan M