日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of functional genetic components modulating toxicity response to PFOS using genome-wide CRISPR screens in HepG2/C3A cells

利用HepG2/C3A细胞中的全基因组CRISPR筛选,鉴定调控PFOS毒性反应的功能性遗传成分。

Kim, Chanhee; Tagmount, Abderrahmane; Zhu, Zhaohan; Wilson, Frances; Li, Danmeng; Ostrov, David A; Brad Barbazuk, William; Bacher, Rhonda; Vulpe, Chris D

Discovery of a pyridine-piperazine-based small molecule that enhances the activity of peptidase neurolysin

发现一种基于吡啶-哌嗪的小分子,可增强肽酶神经溶素的活性

ElSayed ElZorkany, Heba; Kandil, Haya; Jayaraman, Srinidhi; Aly, Asmaa; Esfahani, Shiva Hadi; Patel, Dhavalkumar; Dannecker, Dennis; Maciag, Monika; Paul, Alyssa; Lowran, Kaitlin; Kumari, Shikha; Bose, Samik; Ostrov, David A; Wu, Colin G; Dickson, Alex; Abbruscato, Thomas J; Trippier, Paul C; Orlando, Benjamin J; Karamyan, Vardan T

HLA-B Alleles With Shared Peptide Binding Specificities Define Global Risk of Co-trimoxazole-Induced Severe Cutaneous Adverse Drug Reactions

具有共同肽结合特异性的HLA-B等位基因决定了复方新诺明诱发严重皮肤不良药物反应的全球风险

Li, Yueran; Gibson, Andrew; Saeed, Hajirah N; Ashraf, Mohammadali; Li, Danmeng; Ostrov, David A; Krantz, Matthew S; Mallal, Simon A; Alves, Eric; Chopra, Abha; Choo, Linda; Dodiuk-Gad, Roni P; Kaffenberger, Benjamin; Drucker, Aaron M; Goh, Michelle S; Ergen, Elizabeth; Micheletti, Robert; Rosenbach, Misha; Martin-Pozo, Michelle D; Gangula, Rama; Williams, Elizabeth A; Yu, Alexis; O'Connor, April; Mahan, Kelby; Kwan, James T; Metcalfe, Derek; Rashad, Ramy; Shanbhag, Swapna S; Tahboub, Mohammed Ali; Pedretti, Sarah; Choshi, Phuti; Chimbetete, Tafadzwa; Selim, Rose; James, Ian; Trubiano, Jason A; Lehloenya, Rannakoe; Peter, Jonny G; Phillips, Elizabeth J

A Case Cluster of Aseptic Meningitis Associated With a Newly Identified Recombinant Echovirus 6/Coxsackievirus B1 Enterovirus

与新发现的重组埃可病毒6/柯萨奇病毒B1肠道病毒相关的无菌性脑膜炎病例群

Cherabuddi, Kartikeya; Tagliamonte, Massimiliano S; Lednicky, John A; Ostrov, David A; Moquin, Tracey L; Thoomkuntla, Vishal Kaushik; Bourgeois, Brian; Kollu, Vidya Sagar; Iovine, Nicole M; Myers, Paul D; Subramaniam, Kuttichantran; Salemi, Marco; Morris, J Glenn Jr

The ExoGAN generative AI framework enables extracellular vesicle-based immunotherapy

ExoGAN生成式人工智能框架实现了基于细胞外囊泡的免疫疗法

Graim, Kiley; Greenberg, Zachary; Torabi, Tina Salehi; Huang, Jiayu; Krepel, Franco; Cahill, James; Ostrov, David; He, Mei

Identification of Functional Genetic Components Modulating Toxicity Response to PFOS using Genome-wide CRISPR Screens in HepG2/C3A cells

利用HepG2/C3A细胞中的全基因组CRISPR筛选鉴定调控PFOS毒性反应的功能性遗传成分

Kim, Chanhee; Tagmount, Abderrahmane; Zhu, Zhaohan; Wilson, Frances; Li, Danmeng; Ostrov, David A; Barbazuk, W Brad; Bacher, Rhonda; Vulpe, Chris D

HLA-B Alleles with Shared Peptide Binding Specificities Define Global Risk of Cotrimoxazole-induced SCAR

具有共同肽结合特异性的HLA-B等位基因决定了复方新诺明诱发严重皮肤不良反应的全球风险。

Li, Yueran; Gibson, Andrew; Saeed, Hajirah N; Tahboub, Mohammad Ali; Li, Danmeng; Ostrov, David A; Krantz, Matthew S; Mallal, Simon A; Alves, Eric; Chopra, Abha; Choo, Linda; Dodiuk-Gad, Roni P; Kaffenberger, Benjamin; Drucker, Aaron M; Goh, Michelle S; Ergen, Elizabeth; Micheletti, Robert; Rosenbach, Misha; Martin-Pozo, Michelle D; Gangula, Rama; Williams, Elizabeth A; Yu, Alexis; O'Connor, April; Mahan, Kelby; Kwan, James T; Metcalfe, Derek; Rashad, Ramy; Shanbhag, Swapna S; Pedretti, Sarah; Choshi, Phuti; Chimbetete, Tafadzwa; Selim, Rose; James, Ian; Trubiano, Jason A; Lehloenya, Rannakoe; Peter, Jonny G; Phillips, Elizabeth J

Exploring MHC class II I-Ab blockade as a potential treatment for Sjögren's disease in the mouse model.

在小鼠模型中探索 MHC II 类 I-Ab 阻断作为干燥症的潜在治疗方法

Voigt Alexandria, Gupta Shivai, Shen Yiran, Glenton Patricia, Li Danmeng, Ostrov David, Bhattacharyya I, Nguyen Cuong Q

HLA-DRB1 is associated with cefaclor-induced immediate hypersensitivity

HLA-DRB1与头孢克洛诱发的速发型超敏反应相关

Park, So-Young; Park, So Young; Seo, Sujin; Kwon, Hyouk-Soo; Kim, Seung-Hyun; Kim, Sae-Hoon; Park, Hye-Kyung; Chang, Yoon-Seok; Kim, Cheol-Woo; Lee, Byung Jae; Park, Hae-Sim; Cho, You Sook; Oh, Heung-Bum; Ostrov, David A; Won, Sungho; Kim, Tae Bum

Evidence of a Sjögren's disease-like phenotype following COVID-19 in mice and humans

小鼠和人类感染新冠病毒后出现类似干燥综合征表型的证据

Shen, Yiran; Voigt, Alexandria; Goranova, Laura; Abed, Mehdi; Kleiner, David E; Maldonado, Jose O; Beach, Margaret; Pelayo, Eileen; Chiorini, John A; Craft, William F; Ostrov, David A; Ramiya, Vijay; Sukumaran, Sukesh; Brown, Ashley N; Hanrahan, Kaley C; Tuanyok, Apichai; Warner, Blake M; Nguyen, Cuong Q