日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment

KRASG12R突变型胰腺癌具有ERK/MAPK转录活性受限和独特的肿瘤微环境。

Burge, Rachel A; Le Roux, Ozgun; Popow, Olesja; Spadafora, Victoria K; Rajesh, Christabelle; Adair, Sara J; Bialousow, Lucas; Murphy, Cailey; Saberi, Samaneh; Vaena, Silvia G; Taquey, Margaret C; Allen, Sarah; Han, Lu; Helke, Kristi L; Sharma, Sudarshana; Ostrowski, Michael C; Guttridge, Denis C; Dincman, Toros A; Bauer, Todd W; Kashatus, David F; McFall, Thomas; Haigis, Kevin M; Hollingsworth, Michael A; Counter, Christopher M; Der, Channing J; Hobbs, G Aaron

High-fat diet and obesity each increase tumor cell proliferation and muscle wasting in experimental cancer cachexia

高脂饮食和肥胖均会加剧实验性癌症恶病质中的肿瘤细胞增殖和肌肉萎缩。

Counts, Brittany R; Bonetto, Andrea; Chan, Ho Lam; Au, Ernie D; Jiang, Yanlin; Couch, Marion E; Guttridge, Denis C; Ostrowski, Michael C; Koniaris, Leonidas G; Zimmers, Teresa A

Randomized Phase II Study of Nab-Paclitaxel and Gemcitabine With or Without Tocilizumab as First-Line Treatment in Advanced Pancreatic Cancer: Survival and Cachexia

一项随机II期研究比较了紫杉醇纳米粒联合吉西他滨(加或不加托珠单抗)作为晚期胰腺癌一线治疗方案的疗效:生存率和恶病质

Chen, Inna M; Johansen, Julia S; Theile, Susann; Silverman, Libbie M; Pelz, Katherine R; Madsen, Kasper; Dajani, Olav; Lim, Kevin Z M; Lorentzen, Torben; Gaafer, Omnia; Koniaris, Leonidas G; Ferreira, Anna C; Neelon, Brian; Guttridge, Denis C; Ostrowski, Michael C; Zimmers, Teresa A; Nielsen, Dorte

Biliverdin reductase A is a major determinant of protective NRF2 signaling

胆绿素还原酶A是保护性NRF2信号传导的主要决定因素

Vasavda, Chirag; Kothari, Ruchita; Ammal Kaidery, Navneet; Chakraborty, Suwarna; Jamuna Tripathi, Sunil; Dhindsa, Ryan S; Ricco, Cristina; Shanmukha, Shruthi; Saberi, Samaneh; Lefler, Julia E; Kothari, Priyanka; Chaubey, Kalyani; Snowman, Adele M; Ostrowski, Michael C; Barone, Eugenio; Iyer, Lakshminarayan M; Aravind, L; Sharma, Sudarshana M; Pieper, Andrew A; Thomas, Bobby; Snyder, Solomon H; Paul, Bindu D

Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling

胆绿素还原酶A是神经保护性Nrf2信号传导的主要决定因素

Vasavda, Chirag; Kothari, Ruchita; Kaidery, Navneet Ammal; Chakraborty, Suwarna; Tripathi, Sunil Jamuna; Dhindsa, Ryan S; Saberi, Samaneh; Lefler, Julia E; Kothari, Priyanka; Chaubey, Kalyani; Ricco, Cristina; Snowman, Adele M; Ostrowski, Michael C; Barone, Eugenio; Iyer, Lakshminarayan M; Aravind, L; Sharma, Sudarshana M; Pieper, Andrew A; Thomas, Bobby; Snyder, Solomon H; Paul, Bindu D

Pancreatic Cancer Induces Population-Specific Switching of Myosin Isoforms and Discrete Activation of Cachexia Genes in Skeletal Muscle Myocytes

胰腺癌诱导骨骼肌肌细胞中肌球蛋白亚型发生群体特异性转换,并离散激活恶病质基因

Counts, Brittany R; Jean, Sephora; Gaafer, Omnia; Ota, Sara K; Inabathini, Iishaan; Guo, Tingbo; Guttridge, Denis C; Ostrowski, Michael C; Koniaris, Leonidas G; Cao, Sha; Roh, Hyun C; Zimmers, Teresa A

Optimization of a mouse model of pancreatic cancer to simulate the human phenotypes of metastasis and cachexia

优化胰腺癌小鼠模型以模拟人类的转移和恶病质表型

Spadafora, Victoria; Pryce, Benjamin R; Oles, Alexander; Talbert, Erin E; Romeo, Martin; Vaena, Silvia; Berto, Stefano; Ostrowski, Michael C; Wang, David J; Guttridge, Denis C

Cancer cachexia: involvement of an expanding macroenvironment

癌症恶病质:不断扩大的宏观环境的参与

Pryce, Benjamin R; Wang, David J; Zimmers, Teresa A; Ostrowski, Michael C; Guttridge, Denis C

The impact of inflammation and acute phase activation in cancer cachexia

炎症和急性期激活对癌症恶病质的影响

Robinson, Tyler P; Hamidi, Tewfik; Counts, Brittany; Guttridge, Denis C; Ostrowski, Michael C; Zimmers, Teresa A; Koniaris, Leonidas G

Hepatic protein kinase Cbeta deficiency mitigates late-onset obesity.

肝脏蛋白激酶Cβ缺乏可减轻迟发性肥胖

Shu Yaoling, Gumma Nikhil, Hassan Faizule, Branch Daniel A, Baer Lisa A, Ostrowski Michael C, Stanford Kristin I, Baskin Kedryn K, Mehta Kamal D