日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of synthetic G-quadruplex DNA as SARS-CoV-2 helicase inhibitor with antiviral, anti-inflammatory and antioxidative properties

发现合成G-四链体DNA可作为SARS-CoV-2解旋酶抑制剂,并具有抗病毒、抗炎和抗氧化特性

Bojkova, Denisa; Steinhorst, Katja; Bechtel, Marco; Zoeller, Nadja; Doll, Monika; Ott, Melanie; Rothweiler, Florian; Rothenburger, Tamara; Riecken, Kristoffer; Fehse, Boris; Kandler, Joshua D; Olmer, Ruth; Alcober-Boquet, Lucia; Michaelis, Martin; Cinatl, Jindrich; Kippenberger, Stefan

Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models

在SARS-CoV-2和MERS感染模型中发现具有增强脑暴露和强效口服疗效的冠状病毒主要蛋白酶抑制剂

Lizzadro, Luca; Li, Jiapeng; Taha, Taha Y; Degotte, Gilles; Detomasi, Tyler C; Zapatero-Belinchon, Francisco J; Hantz, Eric R; Huang, Sijie; Matsui, Yusuke; Henderson, Will R; McCann, Jack T; Montano, Mauricio; Rosecrans, Julia; Torres Pomares, Daniel F; McGovern, Briana L; Diaz-Tapia, Randy; Benjamin, Jared; Gordon, Mary E; Suazo, Isidora D; Settineri, Nicholas S; Diallo, Amy; Krogan, Nevan J; Shoichet, Brian K; Verba, Kliment A; Albrecht, Randy; García-Sastre, Adolfo; White, Kris M; Ott, Melanie; Craik, Charles S; Renslo, Adam R

Drug-Induced Phospholipidosis as an Artifact in Antiviral Drug Repurposing

药物诱导的磷脂沉积症是抗病毒药物再利用中的一种假象

Glenn, Isabella S; Paris, Lu; White, Alex D; Garda, Virginia G; Montano, Mauricio; Khalid, Mir M; Kao, Aimee W; Ott, Melanie; Shoichet, Brian K

CGM23 corresponds to a pan-coronavirus lipopeptide inhibitor potently inhibiting virion fusion

CGM23 是一种泛冠状病毒脂肽抑制剂,能有效抑制病毒颗粒融合。

Matsui, Yusuke; Schwarzer, Roland; Montano, Mauricio; Helmy, Ekram W; Suryawanshi, Rahul K; Taha, Taha Y; Wang, Yan; Angel, Yvonne; Adler, Marc; Sassano, M Flori; Jo, Hyunil; Tarran, Robert; Ott, Melanie; Greene, Warner C

Coupling high-throughput protease enzymology with viral replication reveals biochemical constraints of viral fitness

将高通量蛋白酶酶学与病毒复制相结合,揭示了病毒适应性的生化限制。

Aidlen, Dylan; Vo, William Vinh Thanh; Young, Nicholas J; Rosecrans, Julia; Kurianowicz, Anna; Chuo, Shih-Wei; Asper, Garrison P R; Anderson, Dashiell; Posner, Jacob A; Muir, Duncan F; Freitas, Nicholas; Ott, Melanie; Craik, Charles S; Taha, Taha Y; Pinney, Margaux M

A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity

SARS-CoV-2 Omicron XEC 中的非刺突蛋白核衣壳 R204P 突变会增强炎症反应和致病性。

Tsujino, Shuhei; Tsuda, Masumi; Deguchi, Sayaka; Ito, Jumpei; Taha, Taha Y; Nasser, Hesham; Wang, Lei; Rosecrans, Julia; Suzuki, Rigel; Suzuki, Saori; Yoshimatsu, Kumiko; Ott, Melanie; Ikeda, Terumasa; Sato, Kei; Takayama, Kazuo; Tanaka, Shinya; Tamura, Tomokazu; Fukuhara, Takasuke

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

Mac1 ADP-核糖水解酶是SARS-CoV-2的治疗靶点。

Suryawanshi, Rahul K; Jaishankar, Priyadarshini; Correy, Galen J; Rachman, Moira M; O'Leary, Patrick C; Taha, Taha Y; Matsui, Yusuke; Zapatero-Belinchón, Francisco J; McCavitt-Malvido, Maria; Doruk, Yagmur U; Stevens, Maisie G V; Diolaiti, Morgan E; Jogalekar, Manasi P; Chen, Huadong; Richards, Alicia L; Kongpracha, Pornparn; Bali, Sofia; Montano, Mauricio; Rosecrans, Julia; Matthay, Michael; Togo, Takaya; Gonciarz, Ryan L; Gopalkrishnan, Saumya; Neitz, R Jeffrey; Krogan, Nevan J; Swaney, Danielle L; Shoichet, Brian K; Ott, Melanie; Renslo, Adam R; Ashworth, Alan; Fraser, James S

Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.

携带 NSP6 中 L260F 突变的近期 SARS-CoV-2 变种增强了 RNA 复制和致病性

Taha Taha Y, Ezzatpour Shahrzad, Hayashi Jennifer M, Ye Chengjin, Zapatero-Belinchón Francisco J, Rosecrans Julia A, Kimmerly Gabriella R, Chen Irene P, Walcott Keith, Kurianowicz Anna, Jorgens Danielle M, Chaplin Natalie R, Choi Annette, Buchholz David W, Sahler Julie, Hilt Zachary T, Imbiakha Brian, Vagi-Szmola Cecilia, Montano Mauricio, Stevenson Erica, Gordon Martin, Swaney Danielle L, Krogan Nevan J, Whittaker Gary R, Martinez-Sobrido Luis, Aguilar Hector C, Ott Melanie

Meeting Summary for Keystone Symposia on HIV Cure: Antiretroviral Therapy (ART)-Free Control of HIV Infection in Durban, South Africa, 2025

关于艾滋病治愈的关键研讨会会议纪要:2025 年在南非德班实现无需抗逆转录病毒疗法 (ART) 的艾滋病感染控制

Tanaka, Kiho; Chikowore, Tatenda Jimmy Blessing; Deeks, Steven G; Estes, Jacob D; Ho, Ya-Chi; Jiang, Sizun; Lee, Ming Jie; Li, Chang; Machinda, Albert; Martins, Mauricio; Mdletshe, Patrick; Ndhlovu, Zaza M; Neogi, Ujjwal; Ott, Melanie M; Rasmussen, Thomas A; Reddy, Kavidha; Rutishauser, Rachel L; Farrell-Sherman, Anna; Tiemessen, Caroline T; Voss, James E; Kityo, Cissy; Lewin, Sharon R; Ndung'u, Thumbi; McCune, Joseph M

Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo

发现 AVI-6451,一种强效且选择性的 SARS-CoV-2 ADP-核糖水解酶 Mac1 抑制剂,具有口服体内疗效。

Jaishankar, Priyadarshini; Correy, Galen J; Matsui, Yusuke; Togo, Takaya; Rachman, Moira M; Stevens, Maisie G V; Hantz, Eric R; Zheng, Jeffrey; Diolaiti, Morgan E; Montano, Mauricio; Taha, Taha Y; Rosecrans, Julia; Pampel, Julius; Krogan, Nevan J; Shoichet, Brian K; Ashworth, Alan; Ott, Melanie; Fraser, James S; Renslo, Adam R