日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Preclinical B cell depletion and safety profile of a brain-shuttled crystallizable fragment-silenced CD20 antibody

一种脑穿梭可结晶片段沉默的CD20抗体的临床前B细胞清除和安全性分析

Vanessa L Schumacher ,Solen Pichereau ,Juliana Bessa ,Juergen Bachl ,Sylvia Herter ,Felix C Weber ,Johannes Auer ,Anja Kipar ,Michael Winter ,Martina Stirn ,Michael B Otteneder ,Kevin Brady ,Anne Eichinger-Chapelon ,Adrian Roth ,Nadine Stokar-Regenscheit ,Nicole Clemann ,Shanon Seger ,Claudia Senn ,Juliane Hönig ,Cordula Jany ,Elisa Di Lenarda ,Alain C Tissot ,Christian Klein ,H-Christian von Büdingen ,Robert Mader ,Mohammed Ullah ,Niels Janssen ,Eduard Urich

Innate immune response to AAV-based gene therapy vectors: Mechanisms of complement activation and cytokine release

针对基于腺相关病毒(AAV)基因治疗载体的先天免疫反应:补体激活和细胞因子释放机制

Xicluna, Rebecca; Schwalie, Petra C; Bell, Emma; Von Tell, Desiree; Steiner, Guido; Seeger, Emily; Freen-van Heeren, Julian J; Turksma, Annelies W; Pouw, Richard B; Schwandt, Timo; Otteneder, Michael B; Rispens, Theo; Brouwer, Mieke C; Bertinetti-Lapatki, Cristina; Haegel, Hélène

Investigating brain uptake of a non-targeting monoclonal antibody after intravenous and intracerebroventricular administration

研究静脉注射和脑室内注射后非靶向单克隆抗体的脑吸收情况

Van De Vyver, Arthur J; Walz, Antje-Christine; Heins, Mariette S; Abdolzade-Bavil, Afsaneh; Kraft, Thomas E; Waldhauer, Inja; Otteneder, Michael B

The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance

免疫原性对治疗性抗体药代动力学的影响:免疫复合物形成和抗体效应功能对清除率影响的临床前评估

Eugenia Opolka-Hoffmann, Gregor Jordan, Michael Otteneder, Robin Kieferle, Martin Lechmann, Gerhard Winter, Roland F Staack

"Catch-and-Release" Anti-Carcinoembryonic Antigen Monoclonal Antibody Leads to Greater Plasma and Tumor Exposure in a Mouse Model of Colorectal Cancer

“捕获并释放”抗癌胚抗原单克隆抗体导致小鼠结肠直肠癌模型中血浆和肿瘤暴露增加

Frank A Engler, Joseph Ryan Polli, Tommy Li, Bo An, Michael Otteneder, Jun Qu, Joseph P Balthasar

Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies

纳米示踪和腔衰荡光谱:大分子药物分布研究中的一种新型超灵敏方法

Nicole A Kratochwil, Stephen R Dueker, Dieter Muri, Claudia Senn, HyeJin Yoon, Byung-Yong Yu, Gwan-Ho Lee, Feng Dong, Michael B Otteneder

Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms

单克隆抗体药代动力学的体外至体内转化:应用新生儿 Fc 受体介导的转胞吞试验了解相互作用的清除机制

Claudia A Castro Jaramillo, Sara Belli, Anne-Christine Cascais, Sherri Dudal, Martin R Edelmann, Markus Haak, Marie-Elise Brun, Michael B Otteneder, Mohammed Ullah, Christoph Funk, Franz Schuler, Silke Simon

Interstitial IgG antibody pharmacokinetics assessed by combined in vivo- and physiologically-based pharmacokinetic modelling approaches

通过结合体内和生理药代动力学建模方法评估间质 IgG 抗体药代动力学

Miro J Eigenmann, Tine V Karlsen, Ben-Fillippo Krippendorff, Olav Tenstad, Ludivine Fronton, Michael B Otteneder, Helge Wiig

Distribution of FcRn Across Species and Tissues

FcRn 在物种和组织中的分布

Sari Latvala, Bjoern Jacobsen, Michael B Otteneder, Annika Herrmann, Sven Kronenberg

Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies

肠道肽转运蛋白PEPT1在奥司他韦吸收中的作用:体外和体内研究

Poirier, Agnès; Belli, Sara; Funk, Christoph; Otteneder, Michael B; Portmann, Renée; Heinig, Katja; Prinssen, Eric; Lazic, Stanley E; Rayner, Craig R; Hoffmann, Gerhard; Singer, Thomas; Smith, David E; Schuler, Franz