日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design

共价探针揭示结构化RNA中的小分子结合口袋,并实现生物活性化合物的设计

Kovachka, Sandra; Wang, Jielei; Taghavi, Amirhossein; Jia, Yilin; Asaba, Taro; Wolff, Karen C; Martin, Mason; Yang, Xueyi; Meyer, Samantha M; Ottilie, Sabine; Heacock, Mina; Cheng, Zhong; McNamara, Case W; Dubey, Gurudutt; Chatterjee, Arnab K; Chanda, Sumit; Gallego, José; Childs-Disney, Jessica L; Disney, Matthew D

Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in Plasmodium HSP90 Inhibitors

疟原虫HSP90抑制剂的共同结合位点和不同的耐药谱揭示了新的耐药机制

Ko, Fu-Hsuan; Lukens, Amanda K; de Souza, Mariana Laureano; Foy, Alex; Hsiao, Jason; Ndiaye, Tolla; Okombo, John; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Boonyalai, Nonlawat; Kumpornsin, Krittikorn; Girling, Gareth; Pasaje, Charisse; Godoy, Luiz; Ottilie, Sabine; Durst, Gregory L; Chatterjee, Arnab; Niles, Jacquin; Lee, Marcus; Fidock, David A; Wirth, Dyann F; Winzeler, Elizabeth A

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

恶性疟原虫体外系统进化揭示了耐药性的关键决定因素

Luth Madeline R, Godinez-Macias Karla P, Chen Daisy, Okombo John, Thathy Vandana, Cheng Xiu, Daggupati Sindhu, Davies Heledd, Dhingra Satish K, Economy Jan M, Edgar Rebecca C S, Gomez-Lorenzo Maria G, Istvan Eva S, Jado Juan Carlos, LaMonte Gregory M, Melillo Bruno, Mok Sachel, Narwal Sunil K, Ndiaye Tolla, Ottilie Sabine, Palomo Diaz Sara, Park Heekuk, Peña Stella, Rocamora Frances, Sakata-Kato Tomoyo, Small-Saunders Jennifer L, Summers Robert L, Tumwebaze Patrick K, Vanaerschot Manu, Xia Guoqin, Yeo Tomas, You Ashley, Gamo Francisco-Javier, Goldberg Daniel E, Lee Marcus C S, McNamara Case W, Ndiaye Daouda, Rosenthal Philip J, Schreiber Stuart L, Serra Gloria, De Siqueira-Neto Jair Lage, Skinner-Adams Tina S, Uhlemann Anne-Catrin, Kato Nobutaka, Lukens Amanda K, Wirth Dyann F, Fidock David A, Winzeler Elizabeth A

Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy

酪氨酸tRNA合成酶的反应劫持作为一种新的全生命周期抗疟策略

Xie, Stanley C; Metcalfe, Riley D; Dunn, Elyse; Morton, Craig J; Huang, Shih-Chung; Puhalovich, Tanya; Du, Yawei; Wittlin, Sergio; Nie, Shuai; Luth, Madeline R; Ma, Liting; Kim, Mi-Sook; Pasaje, Charisse Flerida A; Kumpornsin, Krittikorn; Giannangelo, Carlo; Houghton, Fiona J; Churchyard, Alisje; Famodimu, Mufuliat T; Barry, Daniel C; Gillett, David L; Dey, Sumanta; Kosasih, Clara C; Newman, William; Niles, Jacquin C; Lee, Marcus C S; Baum, Jake; Ottilie, Sabine; Winzeler, Elizabeth A; Creek, Darren J; Williamson, Nicholas; Parker, Michael W; Brand, Stephen; Langston, Steven P; Dick, Lawrence R; Griffin, Michael D W; Gould, Alexandra E; Tilley, Leann

Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance

酿酒酵母的适应性实验室进化凸显了转录因子在真菌异生物质抗性中的作用

Ottilie, Sabine; Luth, Madeline R; Hellemann, Erich; Goldgof, Gregory M; Vigil, Eddy; Kumar, Prianka; Cheung, Andrea L; Song, Miranda; Godinez-Macias, Karla P; Carolino, Krypton; Yang, Jennifer; Lopez, Gisel; Abraham, Matthew; Tarsio, Maureen; LeBlanc, Emmanuelle; Whitesell, Luke; Schenken, Jake; Gunawan, Felicia; Patel, Reysha; Smith, Joshua; Love, Melissa S; Williams, Roy M; McNamara, Case W; Gerwick, William H; Ideker, Trey; Suzuki, Yo; Wirth, Dyann F; Lukens, Amanda K; Kane, Patricia M; Cowen, Leah E; Durrant, Jacob D; Winzeler, Elizabeth A

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome

设计对恶性疟原虫具有体内口服疗效且对人蛋白酶体具有选择性的蛋白酶体抑制剂

Xie, Stanley C; Metcalfe, Riley D; Mizutani, Hirotake; Puhalovich, Tanya; Hanssen, Eric; Morton, Craig J; Du, Yawei; Dogovski, Con; Huang, Shih-Chung; Ciavarri, Jeffrey; Hales, Paul; Griffin, Robert J; Cohen, Lawrence H; Chuang, Bei-Ching; Wittlin, Sergio; Deni, Ioanna; Yeo, Tomas; Ward, Kurt E; Barry, Daniel C; Liu, Boyin; Gillett, David L; Crespo-Fernandez, Benigno F; Ottilie, Sabine; Mittal, Nimisha; Churchyard, Alisje; Ferguson, Daniel; Aguiar, Anna Caroline C; Guido, Rafael V C; Baum, Jake; Hanson, Kirsten K; Winzeler, Elizabeth A; Gamo, Francisco-Javier; Fidock, David A; Baud, Delphine; Parker, Michael W; Brand, Stephen; Dick, Lawrence R; Griffin, Michael D W; Gould, Alexandra E; Tilley, Leann

MalDA, Accelerating Malaria Drug Discovery

MalDA,加速疟疾药物研发

Yang, Tuo; Ottilie, Sabine; Istvan, Eva S; Godinez-Macias, Karla P; Lukens, Amanda K; Baragaña, Beatriz; Campo, Brice; Walpole, Chris; Niles, Jacquin C; Chibale, Kelly; Dechering, Koen J; Llinás, Manuel; Lee, Marcus C S; Kato, Nobutaka; Wyllie, Susan; McNamara, Case W; Gamo, Francisco Javier; Burrows, Jeremy; Fidock, David A; Goldberg, Daniel E; Gilbert, Ian H; Wirth, Dyann F; Winzeler, Elizabeth A

Prioritization of Molecular Targets for Antimalarial Drug Discovery

抗疟药物研发中分子靶点的优先排序

Forte, Barbara; Ottilie, Sabine; Plater, Andrew; Campo, Brice; Dechering, Koen J; Gamo, Francisco Javier; Goldberg, Daniel E; Istvan, Eva S; Lee, Marcus; Lukens, Amanda K; McNamara, Case W; Niles, Jacquin C; Okombo, John; Pasaje, Charisse Flerida A; Siegel, Miles G; Wirth, Dyann; Wyllie, Susan; Fidock, David A; Baragaña, Beatriz; Winzeler, Elizabeth A; Gilbert, Ian H

Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery

结合阶段特异性和代谢组学分析推进抗疟药物研发

Murithi, James M; Owen, Edward S; Istvan, Eva S; Lee, Marcus C S; Ottilie, Sabine; Chibale, Kelly; Goldberg, Daniel E; Winzeler, Elizabeth A; Llinás, Manuel; Fidock, David A; Vanaerschot, Manu

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

利用开源方式发现下一代化学保护性抗疟药物的先导化合物

Antonova-Koch, Yevgeniya; Meister, Stephan; Abraham, Matthew; Luth, Madeline R; Ottilie, Sabine; Lukens, Amanda K; Sakata-Kato, Tomoyo; Vanaerschot, Manu; Owen, Edward; Jado, Juan Carlos; Maher, Steven P; Calla, Jaeson; Plouffe, David; Zhong, Yang; Chen, Kaisheng; Chaumeau, Victor; Conway, Amy J; McNamara, Case W; Ibanez, Maureen; Gagaring, Kerstin; Serrano, Fernando Neria; Eribez, Korina; Taggard, Cullin McLean; Cheung, Andrea L; Lincoln, Christie; Ambachew, Biniam; Rouillier, Melanie; Siegel, Dionicio; Nosten, François; Kyle, Dennis E; Gamo, Francisco-Javier; Zhou, Yingyao; Llinás, Manuel; Fidock, David A; Wirth, Dyann F; Burrows, Jeremy; Campo, Brice; Winzeler, Elizabeth A