日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Macrocyclic Molecular Glues for the 14-3-3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship

大环分子胶用于 14-3-3/ChREBP 相互作用：亲和力和协同性呈反比关系

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202521678
Pennings, Marloes A M; van den Bosch, Merel A W; Oberheide, Ansgar; Verhoef, Carlo J A; Ottmann, Christian; Markvoort, Albert J; Miley, Galen P; Brunsveld, Luc
EBP
ChREBP
发表日期：2026
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Modulation of the 14-3-3σ/C-RAF "Auto"inhibited Complex by Molecular Glues

分子胶对 14-3-3σ/C-RAF“自身”抑制复合物的调节

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.5c12622
Konstantinidou, Markella; Vickery, Holly R; Pennings, Marloes A M; Virta, Johanna M; Luo, Shu Yue; Visser, Emira J; Bannier, Sean D; Srikanth, Mrudula; Cismoski, Sabine Z; Young, Lucy C; van den Oetelaar, Maxime C M; McCormick, Frank; Ottmann, Christian; Brunsveld, Luc; Arkin, Michelle R
发表日期：2026
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Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

调节性ChREBP/14-3-3复合物的分子粘合剂保护β细胞免受糖脂毒性损伤

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-57241-7
Katz, Liora S; Visser, Emira J; Plitzko, Kathrin F; Pennings, Marloes A M; Cossar, Peter J; Tse, Isabelle L; Kaiser, Markus; Brunsveld, Luc; Ottmann, Christian; Scott, Donald K
ChREBP
细胞生物学
毒理研究
EBP
发表日期：2025
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Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex.

针对 14-3-3/ERα 复合物的分子胶的支架跃迁

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-61176-4
Konstantinidou Markella, Zingiridis Marios, Pennings Marloes A M, Fragkiadakis Michael, Virta Johanna M, Revalde Jezrael L, Visser Emira J, Ottmann Christian, Brunsveld Luc, Neochoritis Constantinos G, Arkin Michelle R
其它
发表日期：2025
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Proximity-enhanced cysteine-histidine crosslinking for elucidating intrinsically disordered and other protein complexes

利用邻近增强的半胱氨酸-组氨酸交联来阐明固有无序蛋白复合物和其他蛋白复合物

期刊:Chemical Science
影响因子:7.4
doi:10.1039/d4sc07419j
Wu, Qi; van den Wildenberg, Sebastian A H; Brzoskowski, Jeroen C R; van den Oetelaar, Maxime C M; Verhoef, Carlo J A; Genet, Sylvia A A M; Ottmann, Christian; Markvoort, Albert J; Brunsveld, Luc; Cossar, Peter J
发表日期：2025
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Identifying 14-3-3 interactome binding sites with deep learning

利用深度学习识别 14-3-3 相互作用组的结合位点

期刊:Digital Discovery
影响因子:5.6
doi:10.1039/d5dd00132c
van Weesep, Laura; Özçelik, Rıza; Pennings, Marloes; Criscuolo, Emanuele; Ottmann, Christian; Brunsveld, Luc; Grisoni, Francesca
发表日期：2025
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Stoichiometric 14-3-3ζ binding promotes phospho-Tau microtubule dissociation and reduces aggregation and condensation.

化学计量比的 14-3-3ζ 结合促进磷酸化 Tau 微管解离，减少聚集和凝聚

期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-025-08548-0
Hochmair Janine, van den Oetelaar Maxime C M, Ravatt Leandre, Diez Lisa, Lemmens Lenne J M, Ponce-Lina Renata, Sankar Rithika, Franck Maximilian, Nolte Gesa, Semenova Ekaterina, Mohapatra Satabdee, Ottmann Christian, Brunsveld Luc, Wegmann Susanne
其它
磷酸化
发表日期：2025
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Site-specific molecular glues for the 14-3-3/Tau pS214 protein-protein interaction via reversible covalent imine tethering

通过可逆共价亚胺连接实现14-3-3/Tau pS214蛋白-蛋白相互作用的位点特异性分子胶

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d4md00833b
Oberheide, Ansgar; van den Oetelaar, Maxime C M; Scheele, Jakob J A; Borggräfe, Jan; Engelen, Semmy F H; Sattler, Michael; Ottmann, Christian; Cossar, Peter J; Brunsveld, Luc
发表日期：2025
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Modulation of the 14-3-3σ/C-RAF "auto"inhibited complex by molecular glues

分子胶对14-3-3σ/C-RAF“自身”抑制复合物的调节

期刊:
影响因子:
doi:10.1101/2025.07.30.667769
Konstantinidou, Markella; Vickery, Holly R; Pennings, Marloes A M; Virta, Johanna M; Visser, Emira J; Bannier, Sean D; Srikanth, Mrudula; Cismoski, Sabine Z; Young, Lucy C; van den Oetelaar, Maxime C M; McCormick, Frank; Ottmann, Christian; Brunsveld, Luc; Arkin, Michelle R
发表日期：2025
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14-3-3 Protein-Protein Interactions: From Mechanistic Understanding to Their Small-Molecule Stabilization

14-3-3 蛋白质-蛋白质相互作用：从机制理解到小分子稳定化

期刊:Chembiochem
影响因子:2.8
doi:10.1002/cbic.202400214
Somsen, Bente A; Cossar, Peter J; Arkin, Michelle R; Brunsveld, Luc; Ottmann, Christian
发表日期：2024
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