日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Response-Adaptive Surgical Timing in Neoadjuvant Immunotherapy Demonstrates Enhanced Pathologic Treatment Response in Head and Neck Squamous Cell Carcinoma

新辅助免疫疗法中反应适应性手术时机可增强头颈部鳞状细胞癌的病理治疗反应

Mastrolonardo, Eric V; Nunes, Kathryn L; Llerena, Pablo; Nikitina, Anastasia; Sobol, Anastasia; Scott, E Reilly; Tuluc, Madalina; Davitt, Christopher J H; Scher, Jessica; Tekumalla, Sruti; Mann, Derek; Henao, Camilo; Jegede, Victor; Gargano, Stacey; Harshyne, Larry A; Alnemri, Angela; Tyshevich, Andrey; Kushnarev, Vladimir; Chasse, Madison; Sookiasian, Danielle; Axelrod, Rita; Zhan, Tingting; Leiby, Benjamin E; Old, Matthew; Seim, Nolan; Mahoney, My G; Martinez-Outschoorn, Ubaldo; Cognetti, David M; Curry, Joseph M; Prendergast, George C; Argiris, Athanassios; South, Andrew P; Linnenbach, Alban J; Johnson, Jennifer M; Luginbuhl, Adam J

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis.

TOMM20 通过氧化磷酸化、维持还原状态和抵抗细胞凋亡来驱动癌症的侵袭性

Islam Ranakul, Roche Megan E, Lin Zhao, Whitaker-Menezes Diana, Diaz-Barros Victor, Serrano Eurico, Martinez Cantarin Maria Paula, Philp Nancy J, Basu Mallick Atrayee, Martinez-Outschoorn Ubaldo

Tumor microenvironment governs the prognostic landscape of immunotherapy for head and neck squamous cell carcinoma: A computational model-guided analysis

肿瘤微环境决定头颈部鳞状细胞癌免疫治疗的预后:基于计算模型的分析

Bhattacharya, Priyan; Linnenbach, Alban; South, Andrew P; Martinez-Outschoorn, Ubaldo; Curry, Joseph M; Johnson, Jennifer M; Harshyne, Larry A; Mahoney, Mỹ G; Luginbuhl, Adam J; Vadigepalli, Rajanikanth

Extracellular Matrix-MYCAF Signatures Correlate with Resistance to Neoadjuvant aPD-L1 Immune Checkpoint Inhibition with Durvalumab + Metformin in HPV+ HNSCC

细胞外基质-MYCAF 特征与 HPV 阳性头颈部鳞状细胞癌患者对新辅助 PD-L1 免疫检查点抑制剂度伐利尤单抗联合二甲双胍治疗的耐药性相关

Llerena, Pablo; Samarah, Hani; Nunes, Kathryn; Lin, Zhao; Bridgham, Kelly; Tekumalla, Sruti; Jain, Amiti; Harshyne, Larry; Shukla, Sanket K; Vathiotis, Ioannis; Tuluc, Madalina; Gargano, Stacey; Eisenbrey, John R; Keith, Scott; Cognetti, David M; Bar-Ad, Voichita C; Luginbuhl, Adam J; Axelrod, Rita; Vadigepalli, Rajanikanth; Yang, Hushan; Whitaker-Menezes, Diana; Roche, Megan; Mahoney, My G; Argiris, Athanassios; Solomides, Charalambos; Johnson, Jennifer M; Barbirou, Mouadh; Miller, Amanda; South, Andrew P; Mitra, Ramkrishna; Linnenbach, Alban J; Martinez-Outschoorn, Ubaldo; Curry, Joseph M

MiR-200c reprograms fibroblasts to recapitulate the phenotype of CAFs in breast cancer progression

MiR-200c 重新编程成纤维细胞以重现乳腺癌进展中 CAF 的表型

Zhao Lin, Megan E Roche, Víctor Díaz-Barros, Marina Domingo-Vidal, Diana Whitaker-Menezes, Madalina Tuluc, Guldeep Uppal, Jaime Caro, Joseph M Curry, Ubaldo Martinez-Outschoorn

Altered extracellular matrix correlates with an immunosuppressive tumor microenvironment and disease progression in younger adults with oral cavity squamous cell carcinoma

细胞外基质的改变与年轻成人口腔鳞状细胞癌患者的免疫抑制性肿瘤微环境和疾病进展相关。

Estephan, Leonard E; Kumar, Gaurav; Stewart, Matthew; Banoub, Raphael; Linnenbach, Alban; Harshyne, Larry A; Martinez-Outschoorn, Ubaldo E; Mahoney, My G; Curry, Joseph M; Johnson, Jennifer; South, Andrew P; Luginbuhl, Adam J

TP53 Induced Glycolysis and Apoptosis Regulator and Monocarboxylate Transporter 4 drive metabolic reprogramming with c-MYC and NFkB activation in breast cancer

TP53诱导的糖酵解和凋亡调节因子以及单羧酸转运蛋白4通过c-MYC和NF-κB激活驱动乳腺癌的代谢重编程

Roche, Megan E; Ko, Ying-Hui; Domingo-Vidal, Marina; Lin, Zhao; Whitaker-Menezes, Diana; Birbe, Ruth C; Tuluc, Madalina; Győrffy, Balázs; Caro, Jaime; Philp, Nancy J; Bartrons, Ramon; Martinez-Outschoorn, Ubaldo

IL-8 correlates with nonresponse to neoadjuvant nivolumab in HPV positive HNSCC via a potential extracellular vesicle miR-146a mediated mechanism

IL-8 与 HPV 阳性头颈部鳞状细胞癌 (HNSCC) 对新辅助纳武利尤单抗治疗无反应相关,其机制可能涉及细胞外囊泡 miR-146a。

Hill, Brianna L; Calder, Alyssa N; Flemming, Joseph P; Guo, Yiyang; Gilmore, Sydney L; Trofa, Melissa A; Daniels, Sean K; Nielsen, Torbjoern N; Gleason, Laura K; Antysheva, Zoya; Demina, Ksenia; Kotlov, Nikita; Davitt, Christopher J H; Cognetti, David M; Prendergast, George C; Snook, Adam E; Johnson, Jennifer M; Kumar, Gaurav; Linnenbach, Alban J; Martinez-Outschoorn, Ubaldo; South, Andrew P; Curry, Joseph M; Harshyne, Larry A; Luginbuhl, Adam J; Mahoney, Mỹ G

CD8+ and FoxP3+ T-Cell Cellular Density and Spatial Distribution After Programmed Death-Ligand 1 Check Point Inhibition

程序性死亡配体 1 检查点抑制后的 CD8+ 和 FoxP3+ T 细胞密度和空间分布

Joseph Curry, Angela Alnemri, Ramez Philips, Michele Fiorella, Sarah Sussman, Robert Stapp, Charalambos Solomides, Larry Harshyne, Andrew South, Adam Luginbuhl, Madalina Tuluc, Ubaldo Martinez-Outschoorn, Athanassios Argiris, Alban Linnenbach, Jennifer Johnson

Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition

二甲双胍通过抑制 CXCL1 增强头颈部鳞状细胞癌的自然杀伤细胞功能

McKenzie Crist, Benyamin Yaniv, Sarah Palackdharry, Maria A Lehn, Mario Medvedovic, Timothy Stone, Shuchi Gulati, Vidhya Karivedu, Michael Borchers, Bethany Fuhrman, Audrey Crago, Joseph Curry, Ubaldo Martinez-Outschoorn, Vinita Takiar, Trisha M Wise-Draper1