日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A first-in-class selective inhibitor of ERK1/2 and ERK5 overcomes drug resistance with a single-molecule strategy.

首创的 ERK1/2 和 ERK5 选择性抑制剂采用单分子策略克服了耐药性

Xiao Huan, Wang Aoxue, Shuai Wen, Qian Yuping, Wu Chengyong, Wang Xin, Yang Panpan, Sun Qian, Wang Guan, Ouyang Liang, Sun Qiu

A transformer-based strategy to develop RP20 as a potent RIPK2 inhibitor for acetaminophen-induced acute liver injury

基于Transformer的策略开发RP20,使其成为治疗对乙酰氨基酚引起的急性肝损伤的有效RIPK2抑制剂。

Ouyang, Liang

The epigenetic landscape of rheumatoid arthritis: Pathogenesis and drug therapeutic potentials

类风湿性关节炎的表观遗传图谱:发病机制和药物治疗潜力

Huang, Chengcheng; Liang, Yuxiang; Li, Yang; Wei, Quan; Ouyang, Liang; Zhang, Jifa

Unraveling Small Molecule-Mediated Sirtuin 3 Activation at a Distinct Binding Site for Cardioprotective Therapies.

揭示小分子介导的 Sirtuin 3 在特定结合位点的激活机制,用于心脏保护疗法

Zhang Dan, Zhang Jifa, Wu Chengyong, Xiao Yao, Ji Liwei, Hu Jiarui, Ding Jianjun, Li Tao, Zhang Yiwen, Ouyang Liang

Multiscale biased chemical space remodeling for developing APLNR agonists with anti-HFpEF efficacy.

多尺度偏向化学空间重塑,用于开发具有抗HFpEF功效的APLNR激动剂

Sun Qiu, Tian Xiaowen, Tan Lun, Deng Yan, Liu Sicen, Xiong Yixiao, Feng Yuying, Wang Yujia, Zhang Lele, Zhu Jiayi, Xiao Huan, Shao Zhenhua, Guo Yingqiang, Yan Wei, Li Tao, Ouyang Liang

Correction: SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice

更正:洛伐他汀增强神经元细胞中SHP2介导的线粒体自噬可缓解小鼠帕金森病症状

Liu, Wen; Wang, Meijing; Shen, Lihong; Zhu, Yuyu; Ma, Hongyue; Liu, Bo; Ouyang, Liang; Guo, Wenjie; Xu, Qiang; Sun, Yang

Small molecule inhibitors targeting m(6)A regulators

靶向m(6)A调节因子的小分子抑制剂

Feng, Guotai; Wu, Yongya; Hu, Yuan; Shuai, Wen; Yang, Xiao; Li, Yong; Ouyang, Liang; Wang, Guan

Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives

癌症中的选择性自噬:机制、治疗意义和未来展望

Liu, Jiaxi; Wu, Yongya; Meng, Sha; Xu, Ping; Li, Shutong; Li, Yong; Hu, Xiuying; Ouyang, Liang; Wang, Guan

The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis

原癌基因酪氨酸激酶 c-SRC 通过重塑脂肪酸合成促进胶质母细胞瘤进展

Wentao Zhao #, Cong Ouyang #, Liang Zhang #, Jinyang Wang #, Jiaojiao Zhang #, Yan Zhang, Chen Huang, Qiao Xiao, Bin Jiang, Furong Lin, Cixiong Zhang, Mingxia Zhu, Changchuan Xie, Xi Huang, Bingchang Zhang, Wenpeng Zhao, Jiawei He, Sifang Chen, Xiyao Liu, Donghai Lin, Qinxi Li, Zhanxiang Wang

The crystal structure of human ferroptosis suppressive protein 1 in complex with flavin adenine dinucleotide and nicotinamide adenine nucleotide

人铁死亡抑制蛋白1与黄素腺嘌呤二核苷酸和烟酰胺腺嘌呤核苷酸复合物的晶体结构

Feng, Shijian; Huang, Xiaofang; Tang, Dan; Liu, Xiaoyu; Ouyang, Liang; Yang, Dehua; Wang, Kunjie; Liao, Banghua; Qi, Shiqian