日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Site-directed multivalent conjugation of antibodies to ubiquitinated payloads

抗体与泛素化有效载荷的位点定向多价偶联

Angela F El Hebieshy # ,Zacharias Wijfjes # ,Camille M Le Gall ,Jim Middelburg ,Kim E de Roode ,Felix L Fennemann ,Marjolein Sluijter ,Thorbald van Hall ,Douwe J Dijkstra ,Leendert A Trouw ,Floris J van Dalen ,Andrea Rodgers Furones ,Johan M S van der Schoot ,Ian Derksen ,Hans de Haard ,Bas van der Woning ,Cami M P Talavera Ormeño ,Bjorn R van Doodewaerd ,Carl G Figdor ,Gerbrand J van der Heden van Noort ,Paul W H I Parren ,Sandra Heskamp ,Huib Ovaa ,Martijn Verdoes ,Ferenc A Scheeren

Leveraging Targeted Protein Degradation for G Protein-Coupled Receptors: The Development of CCR2 Molecular Degraders

利用靶向蛋白降解技术调控G蛋白偶联受体:CCR2分子降解剂的开发

Essa, Khaled; Ortiz Zacarías, Natalia V; Roth, Sascha; Xin, Bo-Tao; de Winter, Sabine; van der Horst, Cas; Bleijs, Bente; de Heiden, Richard A; Voulgaraki, Rodanthi; Neubert, Elsa; Ovaa, Huib; Danen, Erik H J; Mulder, Monique P C; Moreau, Kevin; van der Es, Daan; Heitman, Laura H

Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes

利用中子编码的二泛素分析去泛素化酶的连接选择性

van Tol, Bianca D M; van Doodewaerd, Bjorn R; Lageveen-Kammeijer, Guinevere S M; Jansen, Bas C; Talavera Ormeño, Cami M P; Hekking, Paul J M; Sapmaz, Aysegul; Kim, Robbert Q; Moutsiopoulou, Angeliki; Komander, David; Wuhrer, Manfred; van der Heden van Noort, Gerbrand J; Ovaa, Huib; Geurink, Paul P

USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism

USP16 是一种 ISG15 交叉反应性去泛素化酶,靶向参与代谢的 pro-ISG15 和 ISGylated 蛋白。

Gan, Jin; Pinto-Fernández, Adán; Flierman, Dennis; Akkermans, Jimmy J L L; O'Brien, Darragh P; Greenwood, Helene; Scott, Hannah Claire; Fritz, Günter; Knobeloch, Klaus-Peter; Neefjes, Jacques; van Dam, Hans; Ovaa, Huib; Ploegh, Hidde L; Kessler, Benedikt M; Geurink, Paul P; Sapmaz, Aysegul

Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2

化学改良抑制剂的细胞验证鉴定出 OTUB2 上的单泛素化

Jin Gan, Jelle de Vries, Jimmy J L L Akkermans, Yassene Mohammed, Rayman T N Tjokrodirijo, Arnoud H de Ru, Robbert Q Kim, David A Vargas, Vito Pol, Rudi Fasan, Peter A van Veelen, Jacques Neefjes, Hans van Dam, Huib Ovaa, Aysegul Sapmaz, Paul P Geurink

In-Plate Chemical Synthesis of Isopeptide-Linked SUMOylated Peptide Fluorescence Polarization Reagents for High-Throughput Screening of SENP Preferences

用于高通量筛选SENP偏好性的异肽连接SUMO化肽荧光偏振试剂的板内化学合成

Huppelschoten, Yara; Mukhopadhyay, Rishov; Buchardt, Jens; Nielsen, Thomas E; Vertegaal, Alfred C O; Ovaa, Huib; van der Heden van Noort, Gerbrand J

USP8 promotes cancer progression and extracellular vesicle-mediated CD8+ T cell exhaustion by deubiquitinating the TGF-β receptor TβRII

USP8 通过去泛素化 TGF-β 受体 TβRII 促进癌症进展和细胞外囊泡介导的 CD8+ T 细胞耗竭

Feng Xie #, Xiaoxue Zhou #, Heyu Li, Peng Su, Sijia Liu, Ran Li, Jing Zou, Xiang Wei, Chen Pan, Zhengkui Zhang, Min Zheng, Zhuang Liu, Xuli Meng, Huib Ovaa #, Peter Ten Dijke, Fangfang Zhou, Long Zhang

EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers

EGF-SNX3-EGFR 轴驱动三阴性乳腺癌的肿瘤进展和转移

Esra Cicek #, Ayca Circir #, Merve Oyken #, Ozge Akbulut Caliskan, Didem Naz Dioken, Sezen Guntekin Ergun, Rengul Cetin-Atalay, Aysegul Sapmaz, Huib Ovaa, Ozgur Sahin, Ayse Elif Erson-Bensan

Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput

PARK7 化学工具包:高效、高选择性、高通量

Yuqing Jia, Robbert Q Kim, Raymond Kooij, Huib Ovaa, Aysegul Sapmaz, Paul P Geurink

Inhibiting UCH-L5: Rational Design of a Cyclic Ubiquitin-Based Peptide Inhibitor

抑制UCH-L5:基于环状泛素的肽抑制剂的合理设计

Dharjath S Hameed ,Huib Ovaa ,Gerbrand J van der Heden van Noort ,Aysegul Sapmaz