A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment
一种新型 CBS 缺乏型同型胱氨酸尿症转基因小鼠模型不会引起肝脂肪变性或纤维化,并表现出高凝表型,可通过甜菜碱治疗得到改善
期刊:Molecular Genetics and Metabolism
影响因子:3.7
doi:10.1016/j.ymgme.2010.06.010
Kenneth N Maclean, Jakub Sikora, Viktor Kožich, Hua Jiang, Lori S Greiner, Eva Kraus, Jakub Krijt, Katherine H Overdier, Renata Collard, Gary L Brodsky, Lynne Meltesen, Linda S Crnic, Robert H Allen, Sally P Stabler, Milan Elleder, Rima Rozen, David Patterson, Jan P Kraus