日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Plasma Aβ42/40 predicts progression from Aβ-amyloid negative to positive PET scans

血浆Aβ42/40水平可预测PET扫描结果从Aβ淀粉样蛋白阴性进展至阳性。

Feizpour, Azadeh; Doré, Vincent; Bourgeat, Pierrick; Doecke, James D; Canovas, Rodrigo; Laws, Simon M; Porter, Tenielle; Huang, Kun; Fowler, Christopher; Martins, Ralph N; Maruff, Paul; Sohrabi, Hamid R; Weiner, Michael W; Morris, John C; Benzinger, Tammie L S; Schindler, Suzanne E; Bateman, Randall J; Li, Yan; Vitaliy, Ovod; Ward, Larry; Mejan-Fripp, Jurgen; Masters, Colin L; Villemagne, Victor L; Rowe, Christopher C

When Does Alzheimer's Disease Start? Plasma Aβ42/40 Assays Show Steep Changes at Aβ-PET Centiloid 15, Mean Age of 66 Years

阿尔茨海默病何时开始?血浆Aβ42/40检测显示Aβ-PET Centiloid 15试验中出现显著变化,平均年龄为66岁。

Cánovas, Rodrigo; Cox, Timothy; Doré, Vincent; Bourgeat, Pierrick; Fripp, Jurgen; Feizpour, Azadeh; Shishegar, Rosita; Fowler, Christopher J; Laws, Simon M; Porter, Tenielle; Rainey-Smith, Stephanie; Shaw, Leslie M; Bateman, Randall J; Li, Yan; Vitaliy, Ovod; Weiner, Michael W; Morris, John C; Benzinger, Tammie L S; Schindler, Suzanne E; Nakamura, Akinori; Iwatsubo, Takeshi; Ikeuchi, Takeshi; Kato, Takashi; Maruff, Paul; Sohrabi, Hamid R; Rowe, Christopher C; Martins, Ralph N; Masters, Colin L; Doecke, James D

OpenScientist: evaluating an open agentic AI co-scientist to accelerate biomedical discovery

OpenScientist:评估开放式智能AI合作科学家,以加速生物医学发现

Roberts, Kaleigh F; Abrams, Zachary B; Cappelletti, Luca; Moqri, Mahdi; Heugel, Nicholas; Caufield, J Harry; Bourdenx, Mathieu; Li, Yan; Banerjee, Jineta; Foschini, Luca; Galeano, Diego; Harris, Nomi L; Li, Melody; Ying, Kejun; Melendez, Justin A; Barthélemy, Nicolas R; Bollinger, James G; He, Yingxin; Ovod, Vitaliy; Benzinger, Tammie L S; Flores, Shaney; Gordon, Brian A; Ojewole, Adegoke A; Phatak, Mukta; Elbert, Donald L; Biber, Sarah; Landsness, Eric C; Mungall, Christopher J; Bateman, Randall J; Reese, Justin T

Plasma Phosphorylated Tau 217 and Aβ42/40 to Predict Early Brain Aβ Accumulation in People Without Cognitive Impairment

血浆磷酸化Tau蛋白217和Aβ42/40可预测无认知障碍人群早期脑内Aβ积累

Janelidze, Shorena; Barthélemy, Nicolas R; Salvadó, Gemma; Schindler, Suzanne E; Palmqvist, Sebastian; Mattsson-Carlgren, Niklas; Braunstein, Joel B; Ovod, Vitaliy; Bollinger, James G; He, Yingxin; Li, Yan; Raji, Cyrus A; Morris, John C; Holtzman, David M; Ashton, Nicholas J; Blennow, Kaj; Stomrud, Erik; Bateman, Randall J; Hansson, Oskar

A combination of plasma phospho‐tau217 and Aβ42/40 detects early development of amyloid pathology in cognitively unimpaired individuals

血浆磷酸化tau217和Aβ42/40的联合检测可以检测认知功能正常个体中淀粉样蛋白病理的早期发展

Zhao, Ai-Lin; Shen, Kai-Ni; Wang, Ji-Nuo; Huo, Lan-Qing; Li, Jian; Cao, Xin-Xin; Janelidze, Shorena; Barthélemy, Nicolas R; Salvadó, Gemma; Palmqvist, Sebastian; Mattsson‐Carlgren, Niklas; Ovod, Vitaliy; Bollinger, James G; He, Yingxin; Schindler, Suzanne E; Blennow, Kaj; Stomrud, Erik; Bateman, Randall J; Hansson, Oskar

CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer's disease

T217 和 T205 位点的 CSF tau 磷酸化占有率代表了阿尔茨海默病中淀粉样蛋白和 tau 病理的改进生物标志物

Nicolas R Barthélemy, Benjamin Saef, Yan Li, Brian A Gordon, Yingxin He, Kanta Horie, Erik Stomrud, Gemma Salvadó, Shorena Janelidze, Chihiro Sato, Vitaliy Ovod, Rachel L Henson, Anne M Fagan, Tammie L S Benzinger, Chengjie Xiong, John C Morris, Oskar Hansson, Randall J Bateman, Suzanne E Schindler1

Acute sleep loss decreases CSF-to-blood clearance of Alzheimer's disease biomarkers

急性睡眠不足会降低脑脊液到血液中阿尔茨海默病生物标志物的清除率

Haiyan Liu, Nicolas R Barthélemy, Vitaliy Ovod, James G Bollinger, Yingxin He, Samir L Chahin, Brendan Androff, Randall J Bateman, Brendan P Lucey

Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS

Suvorexant 急剧降低人类中枢神经系统中的 Tau 磷酸化和 Aβ

Brendan P Lucey, Haiyan Liu, Cristina D Toedebusch, David Freund, Tiara Redrick, Samir L Chahin, Kwasi G Mawuenyega, James G Bollinger, Vitaliy Ovod, Nicolas R Barthélemy, Randall J Bateman

Cognitive impact of multidomain intervention and omega 3 according to blood Aβ42/40 ratio: a subgroup analysis from the randomized MAPT trial

根据血液 Aβ42/40 比值评估多领域干预和 omega-3 对认知的影响:来自随机 MAPT 试验的亚组分析

Delrieu, Julien; Vellas, Bruno; Guyonnet, Sophie; Cantet, Christelle; Ovod, Vitaliy; Li, Yan; Bollinger, James; Bateman, Randall; Andrieu, Sandrine

Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques

血浆淀粉样蛋白-β 42/40 检测阿尔茨海默病淀粉样斑块的验证

Yan Li, Suzanne E Schindler, James G Bollinger, Vitaliy Ovod, Kwasi G Mawuenyega, Michael W Weiner, Leslie M Shaw, Colin L Masters, Christopher J Fowler, John Q Trojanowski, Magdalena Korecka, Ralph N Martins, Shorena Janelidze, Oskar Hansson, Randall J Bateman