Ozcan Lale相关文献与解析，生知库 | 链接生命科学的每一步

Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance

肥胖状态下，肝细胞DACH1表达增加，其机制是通过HDAC4核外排阻促进肝脏胰岛素抵抗。

doi:10.1016/j.celrep.2016.05.006

Ozcan, Lale; Ghorpade, Devram S; Zheng, Ze; de Souza, Jane Cristina; Chen, Ke; Bessler, Marc; Bagloo, Melissa; Schrope, Beth; Pestell, Richard; Tabas, Ira

Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in Obesity

抑制适应性免疫细胞活化并不改变肥胖中的先天性免疫脂肪组织炎症或胰岛素抵抗

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0135842

Subramanian, Manikandan; Ozcan, Lale; Ghorpade, Devram Sampat; Ferrante, Anthony W Jr; Tabas, Ira

炎症

炎症/感染

Immunology/Inflammation

Common therapeutic targets in cardiometabolic disease

心血管代谢疾病的常见治疗靶点

期刊:Science Translational Medicine

影响因子:14.6

doi:10.1126/scitranslmed.3008908

Fredman, Gabrielle; Ozcan, Lale; Tabas, Ira

代谢

发表日期：2014

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Role of endoplasmic reticulum stress in metabolic disease and other disorders

内质网应激在代谢性疾病和其他疾病中的作用

期刊:Annual Review of Medicine

影响因子:22.1

doi:10.1146/annurev-med-043010-144749

Ozcan, Lale; Tabas, Ira

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

NADPH氧化酶将内质网应激、氧化应激和PKR激活联系起来，从而诱导细胞凋亡。

期刊:Journal of Cell Biology

影响因子:6.4

doi:10.1083/jcb.201006121

Li, Gang; Scull, Christopher; Ozcan, Lale; Tabas, Ira

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.

钙/钙调蛋白依赖性蛋白激酶 II 将内质网应激与 Fas 和线粒体凋亡途径联系起来

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI38857

Timmins Jenelle M, Ozcan Lale, Seimon Tracie A, Li Gang, Malagelada Cristina, Backs Johannes, Backs Thea, Bassel-Duby Rhonda, Olson Eric N, Anderson Mark E, Tabas Ira

RAP1A suppresses hepatic steatosis by regulating amino acid-mediated mTORC1 activation

RAP1A通过调节氨基酸介导的mTORC1激活来抑制肝脂肪变性。

Targeting Soluble DPP-4 for Insulin Resistance: Origin Matters

靶向可溶性 DPP-4 治疗胰岛素抵抗：来源至关重要

Allosteric MAPKAPK2 inhibitors improve plaque stability in advanced atherosclerosis

变构MAPKAPK2抑制剂可改善晚期动脉粥样硬化斑块的稳定性

A New Activator of Hepatocyte CaMKII in Fasting and Type 2 Diabetes

空腹和2型糖尿病中肝细胞CaMKII的新激活剂

Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance

肥胖状态下，肝细胞DACH1表达增加，其机制是通过HDAC4核外排阻促进肝脏胰岛素抵抗。

Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in Obesity

抑制适应性免疫细胞活化并不改变肥胖中的先天性免疫脂肪组织炎症或胰岛素抵抗

Common therapeutic targets in cardiometabolic disease

心血管代谢疾病的常见治疗靶点

Role of endoplasmic reticulum stress in metabolic disease and other disorders

内质网应激在代谢性疾病和其他疾病中的作用

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

NADPH氧化酶将内质网应激、氧化应激和PKR激活联系起来，从而诱导细胞凋亡。

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.

钙/钙调蛋白依赖性蛋白激酶 II 将内质网应激与 Fas 和线粒体凋亡途径联系起来