日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health

肝X受体α的有害突变具有肝毒性,并与肝脏健康中的胆固醇感知有关。

Sam M Lockhart # ,Milan Muso # ,Ilona Zvetkova ,Brian Y H Lam ,Alessandra Ferrari ,Erik Schoenmakers ,Katie Duckett ,Jack Leslie ,Amy Collins ,Beatriz Romartínez-Alonso ,John A Tadross ,Raina Jia ,Eugene J Gardner ,Katherine Kentistou ,Yajie Zhao ,Felix Day ,Alexander Mörseburg ,Kara Rainbow ,Debra Rimmington ,Matteo Mastantuoni ,James Harrison ,Meritxell Nus ,Khalid Guma'a ,Sam Sherratt-Mayhew ,Xiao Jiang ,Katherine R Smith ,Dirk S Paul ,Benjamin Jenkins ,Albert Koulman ,Maik Pietzner ,Claudia Langenberg ,Nicholas Wareham ,Giles S Yeo ,Krishna Chatterjee ,John Schwabe ,Fiona Oakley ,Derek A Mann ,Peter Tontonoz ,Anthony P Coll ,Ken Ong ,John R B Perry ,Stephen O'Rahilly

The gastrointestinal tract is a major source of the acute metformin-stimulated rise in GDF15

胃肠道是二甲双胍刺激 GDF15 急性升高的主要来源

John W R Kincaid, Debra Rimmington, John A Tadross, Irene Cimino, Ilona Zvetkova, Arthur Kaser, Paul Richards, Satish Patel, Stephen O'Rahilly, Anthony P Coll

The Synthesis of Novel aza-Steroids and α, β-Unsaturated-Cyanoketone from Diosgenin

由薯蓣皂苷元合成新型氮杂甾类化合物和α,β-不饱和氰酮

Mesa, Dayana; Augusto, Yarelys E; Hernández, Giselle; Figueroa-Macías, Juan P; Coll, Francisco; Olea, Andrés F; Núñez, María; Campo, Hernán Astudillo; Coll, Yamilet; Espinoza, Luis

Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells

二甲双胍抑制线粒体功能可增加肠道细胞的葡萄糖吸收、糖酵解和 GDF-15 释放

Ming Yang, Tamana Darwish, Pierre Larraufie, Debra Rimmington, Irene Cimino, Deborah A Goldspink, Benjamin Jenkins, Albert Koulman, Cheryl A Brighton, Marcella Ma, Brian Y H Lam, Anthony P Coll, Stephen O'Rahilly, Frank Reimann, Fiona M Gribble

Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity

小鼠神经元蛋白缺乏与食物摄入量高度波动和双峰肥胖有关。

Irene Cimino,Debra Rimmington,Y C Loraine Tung,Katherine Lawler,Pierre Larraufie,Richard G Kay,Samuel Virtue,Brian Y H Lam,Luca Fagnocchi,Marcella K L Ma,Vladimir Saudek,Ilona Zvetkova,Antonio Vidal-Puig,Giles S H Yeo,I Sadaf Farooqi,J Andrew Pospisilik,Fiona M Gribble,Frank Reimann,Stephen O'Rahilly,Anthony P Coll

Chronic glucocorticoid treatment induces hepatic lipid accumulation and hyperinsulinaemia in part through actions on AgRP neurons

慢性糖皮质激素治疗部分通过作用于 AgRP 神经元来诱导肝脏脂质积聚和高胰岛素血症

Erika Harno, Charlotte Sefton, Jonathan R Wray, Tiffany-Jayne Allen, Alison Davies, Anthony P Coll, Anne White

GDF15 mediates the effects of metformin on body weight and energy balance

GDF15 介导二甲双胍对体重和能量平衡的影响

Anthony P Coll #, Michael Chen, Pranali Taskar, Debra Rimmington, Satish Patel, John A Tadross, Irene Cimino, Ming Yang, Paul Welsh, Samuel Virtue, Deborah A Goldspink, Emily L Miedzybrodzka, Adam R Konopka, Raul Ruiz Esponda, Jeffrey T-J Huang, Y C Loraine Tung, Sergio Rodriguez-Cuenca, Rute A Toma

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

GDF15在小鼠和人类中提供营养应激的内分泌信号

Satish Patel,Anna Alvarez-Guaita,Audrey Melvin,Debra Rimmington,Alessia Dattilo,Emily L Miedzybrodzka,Irene Cimino,Anne-Catherine Maurin,Geoffrey P Roberts,Claire L Meek,Samuel Virtue,Lauren M Sparks,Stephanie A Parsons,Leanne M Redman,George A Bray,Alice P Liou,Rachel M Woods,Sion A Parry,Per B Jeppesen,Anders J Kolnes,Heather P Harding,David Ron,Antonio Vidal-Puig,Frank Reimann,Fiona M Gribble,Carl J Hulston,I Sadaf Farooqi,Pierre Fafournoux,Steven R Smith,Jorgen Jensen,Danna Breen,Zhidan Wu,Bei B Zhang,Anthony P Coll,David B Savage,Stephen O'Rahilly

Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment

慢性糖皮质激素治疗后弓状核的整体转录组分析

Jonathan R Wray, Alison Davies, Charlotte Sefton, Tiffany-Jayne Allen, Antony Adamson, Philip Chapman, Brian Y H Lam, Giles S H Yeo, Anthony P Coll, Erika Harno, Anne White

Metabolic Abnormalities of Chronic High-Dose Glucocorticoids Are Not Mediated by Hypothalamic AgRP in Male Mice

慢性高剂量糖皮质激素引起的雄性小鼠代谢异常并非由下丘脑 AgRP 介导

Charlotte Sefton, Alison Davies, Tiffany-Jayne Allen, Jonathan R Wray, Rosemary Shoop, Antony Adamson, Neil Humphreys, Anthony P Coll, Anne White, Erika Harno