DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice
DNMT3A(R882H)突变和Tet2失活协同作用,导致DNA甲基化控制失调,从而诱发小鼠淋巴系统恶性肿瘤
期刊:Leukemia
影响因子:12.8
doi:10.1038/leu.2016.29
L Scourzic, L Couronné, M T Pedersen, V Della Valle, M Diop, E Mylonas, J Calvo, E Mouly, C K Lopez, N Martin, M Fontenay, A Bender, S Guibert, P Dubreuil, P Dessen, N Droin, F Pflumio, M Weber, P Gaulard, K Helin, T Mercher, O A Bernard