日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Exosome Proteomics of SOD1(D90A) Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

SOD1(D90A)突变的外泌体蛋白质组学研究揭示了早期疾病机制,FN1可作为生物标志物

Gautam, Mukesh; Laith, Ali; Gunel, Aslihan; Yilmaz, Melda; Basak, Nazli; Idrisoglu, Halil; Ozdinler, P Hande

Identification of a glia-associated amyloid β oligomer subtype and the rescue from reactive astrogliosis by inhibitor NU-9

鉴定一种与胶质细胞相关的β淀粉样蛋白寡聚体亚型,以及抑制剂NU-9对反应性星形胶质增生的挽救作用

Kranz, Daniel L; de Leon Velez, Omar; Ulupinar, Emel; Ozdinler, P Hande; Silverman, Richard B; Klein, William L

Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

Spastin 和 alsin 蛋白相互作用组分析开始揭示关键的经典通路,并提示新的潜在药物靶点。

Helmold, Benjamin R; Ahrens, Angela; Fitzgerald, Zachary; Ozdinler, P Hande

Cell Type-Specific Alterations in Excitability and Inhibition of Upper Motor Neurons in AlsinKO Mice, a Model of Juvenile Onset ALS

AlsinKO小鼠(一种青少年发病型ALS模型)上运动神经元兴奋性和抑制性的细胞类型特异性改变

Dey, Soumil; Quintanilla, Christopher; Bitlis, Dila; Gautam, Mukesh; Ozdinler, P Hande; Martina, Marco

High-density multielectrode arrays bring cellular resolution to neuronal activity and network analyses of corticospinal motor neurons

高密度多电极阵列可将细胞分辨率应用于皮质脊髓运动神经元的神经元活动和网络分析。

Quintanilla, Christopher A; Fitzgerald, Zachary; Kashow, Omar; Radojicic, Mihailo S; Ulupinar, Emel; Bitlis, Dila; Genc, Baris; Andjus, Pavle; van Drongelen, Wim; Ozdinler, P Hande

DNA double-strand break-capturing nuclear envelope tubules drive DNA repair

DNA双链断裂捕获核膜小管驱动DNA修复

Mitra Shokrollahi #, Mia Stanic #, Anisha Hundal #, Janet N Y Chan, Defne Urman, Chris A Jordan, Anne Hakem, Roderic Espin, Jun Hao, Rehna Krishnan, Philipp G Maass, Brendan C Dickson, Manoor P Hande, Miquel A Pujana, Razqallah Hakem, Karim Mekhail

Sleep Apnea and Amyotrophic Lateral Sclerosis: Cause, Correlation, Any Relation?

睡眠呼吸暂停与肌萎缩侧索硬化症:病因、相关性、是否存在关联?

Ozdinler, P Hande

Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis

针对不同细胞病理的小分子药物用于治疗肌萎缩侧索硬化症

Elmansy, Mohamed F; Reidl, Cory T; Rahaman, Mizzanoor; Özdinler, P Hande; Silverman, Richard B

SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function

SBT-272 通过调节线粒体的完整性、运动性和功能来改善 ALS 上运动神经元中的 TDP-43 病理

Mukesh Gautam, Barış Genç, Benjamin Helmold, Angela Ahrens, Janis Kuka, Marina Makrecka-Kuka, Aksu Günay, Nuran Koçak, Izaak R Aguilar-Wickings, Dennis Keefe, Guozhu Zheng, Suchitra Swaminathan, Martin Redmon, Hatim A Zariwala, P Hande Özdinler

TDP-43 protein interactome informs about perturbed canonical pathways and may help develop personalized medicine approaches for patients with TDP-43 pathology

TDP-43蛋白相互作用组能够反映异常的经典通路,并可能有助于为TDP-43病理患者开发个性化治疗方案。

Helmold, Benjamin R; Pauss, Kate E; Ozdinler, P Hande