日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Myxarylin: Total In Vitro Biosynthesis, Expansion of Substrate Scope, and Bioengineered Thioamidated Biarylitides

Myxarylin:体外生物合成总量、底物范围扩展及生物工程硫代酰胺化双芳基酯

Sikandar, Asfandyar; Vianey, Lana; Schließmann, Kai; Shen, Qiyao; Mackay, C Logan; Haeckl, F P Jake; Urlacher, Vlada B; Naismith, James H; Müller, Rolf

Phylogeny-Aware Metabologenomics Accurately Assigns Natural Products to Biosynthetic Gene Clusters

基于系统发育的代谢基因组学能够准确地将天然产物分配到生物合成基因簇中

Boldt, Judith; Porten, Christoph; Haeckl, F P Jake; Hug, Joachim J; Panter, Fabian; Steglich, Matthias; Wink, Joachim; Overmann, Jörg; Göker, Markus; Krug, Daniel; Müller, Rolf; Nübel, Ulrich

HTS Identifies NUP98-KDM5A-PHD3 Domain Ligands with Novel Scaffolds

高通量筛选鉴定出具有新型支架的NUP98-KDM5A-PHD3结构域配体

Lin, Wenwei; Slavish, P Jake; Phillips, Aaron H; Trotter, Marlon; Yang, Guangwei; Chai, Sergio C; Churion, Kelly; Ochoada, Jason; Das, Sourav; Shelat, Anang A; Mullighan, Charles G; Kriwacki, Richard W; Rankovic, Zoran; Chen, Taosheng

Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins

阐明强效抗结核抗生素 Mycoplanecins 的异常生物合成和 DnaN 靶向作用方式

Chengzhang Fu #, Yunkun Liu #, Christine Walt #, Sari Rasheed #, Chantal D Bader, Peer Lukat, Markus Neuber, F P Jake Haeckl, Wulf Blankenfeldt, Olga V Kalinina, Rolf Müller

Domain-Selective BET Ligands Yield Next-Generation Synthetic Genome Readers/Regulators with Nonidentical Cellular Functions

具有结构域选择性的BET配体可产生具有不同细胞功能的下一代合成基因组读取器/调节器

Mohammed, Ashraf; Waddell, M Brett; Sutkeviciute, Ieva; Danda, Adithi; Philips, Steven J; Lang, Walter; Slavish, P Jake; Kietlinska, Sandra J; Kaulage, Mangesh; Sourav, Das; Ansari, Aseem Z

Fighting antibiotic resistance-strategies and (pre)clinical developments to find new antibacterials

对抗抗生素耐药性——寻找新型抗菌药物的策略和(临床前)研究进展

Walesch, Sebastian; Birkelbach, Joy; Jézéquel, Gwenaëlle; Haeckl, F P Jake; Hegemann, Julian D; Hesterkamp, Thomas; Hirsch, Anna K H; Hammann, Peter; Müller, Rolf

The Faith, Activity, and Nutrition (FAN) dissemination and implementation study: changes in and maintenance of organizational practices over 24 months in a statewide initiative

信仰、活动和营养 (FAN) 推广和实施研究:一项全州性倡议中组织实践在 24 个月内的变化和维持情况

Wilcox, Sara; Day, Kelsey R; Saunders, Ruth P; Jake-Schoffman, Danielle E; Kaczynski, Andrew T; Stucker, Jessica; Dunn, Caroline G; Bernhart, John A

Small molecule SJ572946 activates BAK to initiate apoptosis

小分子SJ572946激活BAK启动细胞凋亡

Giridhar Sekar ,Geetika Singh ,Xingping Qin ,Cristina D Guibao ,Brittany Schwam ,Zintis Inde ,Christy R Grace ,Weixing Zhang ,P Jake Slavish ,Wenwei Lin ,Taosheng Chen ,Richard E Lee ,Zoran Rankovic ,Kristopher Sarosiek ,Tudor Moldoveanu

High-throughput functional annotation of natural products by integrated activity profiling

通过综合活性分析对天然产物进行高通量功能注释

Suzie K Hight, Trevor N Clark, Kenji L Kurita, Elizabeth A McMillan, Walter Bray, Anam F Shaikh, Aswad Khadilkar, F P Jake Haeckl, Fausto Carnevale-Neto, Scott La, Akshar Lohith, Rachel M Vaden, Jeon Lee, Shuguang Wei, R Scott Lokey, Michael A White, Roger G Linington, John B MacMillan

Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators

从聚焦的 Cereblon 调节剂库中鉴定高效、选择性强且口服生物利用度高的小分子 GSPT1/2 降解剂

Gisele Nishiguchi,Fatemeh Keramatnia,Jaeki Min,Yunchao Chang,Barbara Jonchere,Sourav Das,Marisa Actis,Jeanine Price,Divyabharathi Chepyala,Brandon Young,Kevin McGowan,P Jake Slavish,Anand Mayasundari,Jamie A Jarusiewicz,Lei Yang,Yong Li,Xiang Fu,Shalandus H Garrett,James B Papizan,Kiran Kodali,Junmin Peng,Shondra M Pruett Miller,Martine F Roussel,Charles Mullighan,Marcus Fischer,Zoran Rankovic